A new cytotoxic trichothecene macrolide from the endophyte Myrothecium roridum.

abstract：:The cytotoxicity and immunosuppressive activities of jaborosalactone-L and three 16 alpha-oxygenated withanolides from the leaves of Discopodium penninervium were studied. Jaborosalactone-L showed cytotoxicity only to the murine macrophage cell line, RAW 264.7, but the 16 alpha-oxygenated withanolides exhibited cytoto...

journal_title：Planta medica

authors： Habtemariam S

更新日期：1997-02-01 00:00:00

abstract：:Orosunol and 8-demethylorosunol, two new 1-aryl-2,3-naphthalide lignans, have been isolated from Justicia flava root. Structures IV and V respectively have been proposed for them by spectral (UV, IR, PMR, (13)C NMR, and MS) and chemical evidence. ...

journal_title：Planta medica

authors： Olaniyi AA

更新日期：1982-03-01 00:00:00

abstract：:Scutellariae Radix (SR), the root of Scutellaria baicalensis (Labiatae), is widely used in clinical Chinese medicine. In order to investigate the effect of SR on the absorption and disposition of cyclosporine, rats were administered with cyclosporine orally (in the form of the microemulsion Neoral and intravenously wi...

journal_title：Planta medica

authors： Lai MY,Hsiu SL,Hou YC,Tsai SY,Chao PD

更新日期：2004-02-01 00:00:00

abstract：:Blood fluke of the genus Schistosoma are the etiological agents of human schistosomiasis, an important neglected tropical disease that afflicts over 200 million people worldwide. The treatment for this disease relies heavily on a single drug, praziquantel. Recent reports of praziquantel resistance raise concerns about...

journal_title：Planta medica

authors： Moraes Jd,Almeida AA,Brito MR,Marques TH,Lima TC,Sousa DP,Nakano E,Mendonça RZ,Freitas RM

更新日期：2013-03-01 00:00:00

abstract：:A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the...

journal_title：Planta medica

authors： Wen R,Lv H,Jiang Y,Tu P

更新日期：2018-11-01 00:00:00

abstract：:From the fresh rhizomes of Tamus communis five phenanthrenes (1 - 5) were isolated under the guidance of cytotoxic assays in HeLa cells. The compounds were obtained from the highly active CHCl (3) fraction of the MeOH extract by using multistep chromatographic purifications, including VLC, preparative TLC, HPLC and ge...

journal_title：Planta medica

authors： Réthy B,Kovács A,Zupkó I,Forgo P,Vasas A,Falkay G,Hohmann J

更新日期：2006-06-01 00:00:00

abstract：:From the roots of PICRORHIZA KURROOA a new iridoid glycoside, 6-feruloylcatalpol has been isolated, along with veronicoside and minecoside and two phenol glucosides, picein and androsin. ...

journal_title：Planta medica

authors： Stuppner H,Wagner H

更新日期：1989-10-01 00:00:00

abstract：:Four new isoprenylated xanthones, cudraxanthones A, B and C were isolated from the N-hexane extract of the root bark of CUDRANIA TRICUSPIDATA (Carr.) Bur. (Japanese name "Hariguwa"; Moraceae), and cudraxanthone D from the benzene extract. The structures of cudraxanthones A, B, C and D were shown to be 1-4, respectivel...

journal_title：Planta medica

authors： Fujimoto T,Hano Y,Nomura T

更新日期：1984-06-01 00:00:00

abstract：:Many anti-inflammatory agents are known to significantly enhance the terminal differentiation of some cancer cells such as leukemia cells. In this study, the effect of yomogin, a eudesmane sesquiterpene lactone isolated from Artemisia princeps with anti-inflammatory activity, was investigated in human promyelocytic le...

journal_title：Planta medica

authors： Kim SH,Kim TS

更新日期：2002-10-01 00:00:00

abstract：:Infusions of Citrullus colocynthis Schrad. (Cucurbitaceae) fruits are traditionally used as antidiabetic medication in Mediterranean countries, but to our knowledge no studies have been undertaken so far to determine the possible mechanisms involved in the antidiabetic properties of the fruit. The present study was de...

journal_title：Planta medica

authors： Nmila R,Gross R,Rchid H,Roye M,Manteghetti M,Petit P,Tijane M,Ribes G,Sauvaire Y

更新日期：2000-06-01 00:00:00

abstract：:A total of 18 purified lignans was evaluated for antiviral activity against murine cytomegalovirus (CMV) and Sindbis virus, by means of different treatment regimens. Podophyllotoxin and alpha-peltatin were the most potent compounds, and they apparently inhibited murine CMV at an essential early step in the replication...

journal_title：Planta medica

authors： MacRae WD,Hudson JB,Towers GH

更新日期：1989-12-01 00:00:00

abstract：:Three new glycosides, 1,4,8-trihydroxynaphthalene-1-O-D-glucopyranosyl-(1-->6)-beta-D- xylopyranoside (1), 1,4,8-trihydroxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)-alph a-L- arabinopyranoside (2), 1-hydroxy-4-methoxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)- alpha-L-rhamnopyranoside (3), were isolated from th...

journal_title：Planta medica

authors： Lee SW,Lee KS,Son JK

更新日期：2000-03-01 00:00:00

abstract：:Four new iridoids viz., plumeridoids A, B, and C and epiplumeridoid C were isolated from the stem bark of Plumeria rubra Linn. together with twenty-four known compounds viz., 1-( P-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, P- E-coumaric a...

journal_title：Planta medica

authors： Kuigoua GM,Kouam SF,Ngadjui BT,Schulz B,Green IR,Choudhary MI,Krohn K

更新日期：2010-04-01 00:00:00

abstract：:A gas-chromatographical method is described on which seven pyrrolizidine alkaloids (Fuchsisenecionine, Senecionine, Senecivernine, Senkirkine, Retrorsine, O (7)-Angelylheliotridine and Heliotrine) are determinated in a qualitative way and their ratio of concentration in Senecio fuchsii, vernalis, inaequidens and ovire...

journal_title：Planta medica

authors： Wiedenfeld H,Pastewka U,Stengl P,Röder E

更新日期：1981-02-01 00:00:00

abstract：:The in vitro antiprotozoal activity of 18 natural flavonoids has been determined against Entamoeba histolytica and Giardia lamblia. (-)-Epicatechin, (-)-epigallocatechin and kaempferol were the most active flavonoids against both protozoa. ...

journal_title：Planta medica

authors： Calzada F,Meckes M,Cedillo-Rivera R

更新日期：1999-02-01 00:00:00

abstract：:The chemical investigation of the essential oils from the aerial organs of Bellis perennis L., the common daisy, showed that polyacetylenes were one of the dominant class of compounds. The major constituents, methyl deca-4,6-diynoate and deca-4,6-diynoic acid, and their structural analogues, deca-4,6-diyne, dimethyl o...

journal_title：Planta medica

authors： Avato P,Vitali C,Mongelli P,Tava A

更新日期：1997-12-01 00:00:00

abstract：:The antihyperglycemic action of andrographolide, an active principle in the leaves of Andrographis paniculata (Burm. f.) Nees, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Oral treatment of andrographolide decreased the plasma glucose concentrations of STZ-diabetic rats in a dose-depen...

journal_title：Planta medica

authors： Yu BC,Hung CR,Chen WC,Cheng JT

更新日期：2003-12-01 00:00:00

abstract：:Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. This study was conducted to investigate the efficacy of astilbin on experimental diabetic nephropathy (DN) in vivo and in vitro and its possible mechanisms. Astilbin was added in high glucose stimulated HK-2 cells, streptozotocin-indu...

journal_title：Planta medica

authors： Li GS,Jiang WL,Yue XD,Qu GW,Tian JW,Wu J,Fu FH

更新日期：2009-11-01 00:00:00

abstract：:Stellera chamaejasme, also known as "Langdu", has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic d...

journal_title：Planta medica

authors： Jo BG,Park NJ,Jegal J,Choi S,Lee SW,Yi LW,Kim SN,Yang MH

更新日期：2019-05-01 00:00:00

abstract：:For quantitative determination of grayanotoxin I (1) in plant material, a GC/MS method was developed after trimethylsilyl derivatisation of the analytes. Forskolin (5) was used as an internal standard for quantification. ICH-compliant method validation indicated sufficient specificity, precision, quantitation (15 µg/m...

journal_title：Planta medica

authors： Lechtenberg M,Dierks F,Sendker J,Louis A,Schepker H,Hensel A

更新日期：2014-10-01 00:00:00

abstract：:Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and...

journal_title：Planta medica

authors： Li HM,Tang YL,Zhang ZH,Liu CJ,Li HZ,Li RT,Xia XS

更新日期：2012-01-01 00:00:00

abstract：:Gas chromatography-flame ionization detection (GC-FID) was used to assess the chemical profile and quantification of cannabinoids to identify the differences, if existing, in the chemical constituents of in vitro propagated plants (IVP), conventionally grown plants (VP) and indoor grown mother plants (MP-Indoor) of a ...

journal_title：Planta medica

authors： Chandra S,Lata H,Mehmedic Z,Khan IA,ElSohly MA

更新日期：2010-05-01 00:00:00

abstract：:We present the application of the generative topographic map algorithm to visualize the chemical space populated by natural products and synthetic drugs. Generative topographic maps may be used for nonlinear dimensionality reduction and probabilistic modeling. For compound mapping, we represented the molecules by two-...

journal_title：Planta medica

authors： Miyao T,Reker D,Schneider P,Funatsu K,Schneider G

更新日期：2015-04-01 00:00:00

abstract：:Fractionation of the aqueous extract of Derris scandens stems extract using tests for eicosanoid inhibition resulted in the isolation of three isoflavonoids, genistein, its 7- O-alpha-rhamno(1-->6)-beta-glucosyl glycoside, a new compound, and two known isoprenyl derivatives 3'-gamma,gamma-dimethylallylweighteone and s...

journal_title：Planta medica

authors： Laupattarakasem P,Houghton PJ,Hoult JR

更新日期：2004-06-01 00:00:00

abstract：:Since the beginning of this century, Goji berries and juice are being sold as health food products in western countries and praised in advertisements and in the media for well-being and as an anti-aging remedy. The popularity of Goji products has rapidly grown over the last years thanks to efficient marketing strategi...

journal_title：Planta medica

authors： Potterat O

更新日期：2010-01-01 00:00:00

abstract：:Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with t...

journal_title：Planta medica

authors： Oh H,Ko EK,Jun JY,Oh MH,Park SU,Kang KH,Lee HS,Kim YC

更新日期：2002-10-01 00:00:00

abstract：:Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In danggui buxue tang, the complete functions of astragali radix require the assistance of Angelicae sinensis radix, and both he...

journal_title：Planta medica

authors： Zheng KY,Zhang ZX,Du CY,Zhang WL,Bi CW,Choi RC,Dong TT,Tsim KW

更新日期：2014-02-01 00:00:00

abstract：:The known alkaloids (+/-)-stylopine, (+/-)-sinactine, protopine, (+)-bulbocapnine, (-)-domesticine, (+)-corydine and (+)-isoboldine were found in the mixture of alkaloids from Corydalis marschalliana (Papaveraceae), growing in Bulgaria. The alkaloids dehydronantenine, (+)-nantenine and oxonantenine were isolated for t...

journal_title：Planta medica

authors： Kiryakov HG,Iskrenova E,Kuzmanov B,Evstatieva L

更新日期：1981-03-01 00:00:00

abstract：:The essential oils of Salvia ringens (samples A and B), were analyzed by means of GC and GC/MS. From the seventy-five identified constituents representing 99.82 and 99.86% of the oils, 1,8-cineole and alpha-pinene were the major components. Furthermore, sample B exhibited a very interesting antimicrobial profile after...

journal_title：Planta medica

authors： Tzakou O,Pitarokili D,Chinou IB,Harvala C

更新日期：2001-02-01 00:00:00

abstract：:YANG XIN is a traditional Chinese medicine formulation used for nervous fatigue and consists of a proprietary blend of concentrated extracts from 18 plant ingredients. The 18 constituent plant ingredients, YANG XIN capsules, and formulations 2014-005_1 A and 1B were extracted by consecutive 24-hour macerations with di...

journal_title：Planta medica

authors： Almalki AJ,Zaher A,Simithy J,Keller WJ,Tripp M,Calderón AI

更新日期：2016-08-01 00:00:00