Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium.

abstract：:Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the meth...

journal_title：Planta medica

authors： Lee HY,Yum JH,Rho YK,Oh SJ,Choi HS,Chang HB,Choi DH,Leem MJ,Choi EJ,Ryu JM,Hwang SB

更新日期：2007-11-01 00:00:00

abstract：:Flavonolignan compounds have been isolated from the fruits of SILYBUM MARIANUM subsp. ANATOLICUM and kaempferol 3-sulphate and other flavonoid compounds have been isolated from the aerial parts and were identified. The flavonoid sulphate derivatives are shown to be present in SILYBUM genus for the first time. ...

journal_title：Planta medica

authors： Meriçli AH

更新日期：1988-02-01 00:00:00

abstract：:Six new neo-clerodane diterpenoids (1: -6: ), scutebatas X - Z, A1-C1, along with twelve known ones (7: -18: ) were obtained via the phytochemical investigation of the aerial parts of Scutellaria barbata. Their structures were established by detailed spectroscopic analysis. The absolute configurations of 1: and 2: , a...

journal_title：Planta medica

authors： Yang GC,Hu JH,Li BL,Liu H,Wang JY,Sun LX

更新日期：2018-11-01 00:00:00

abstract：:A new compound kaempferol 3-O-alpha-L-(2"-E-p-coumaroyl)-rhamnopyranoside, as well as the known flavonoids, kaempferol 3-O-beta-D-(6"-E-p-coumaroyl)-glucopyranoside, kaempferol 3-O-alpha-L-(2",3"-di-E-p-coumaroyl)-rhamnopyranoside, and caffeic acid were obtained from the methanolic extract of Platanus orientalis L. bu...

journal_title：Planta medica

authors： Mitrokotsa D,Mitaku S,Demetzos C,Harvala C,Mentis A,Perez S,Kokkinopoulos D

更新日期：1993-12-01 00:00:00

abstract：:From the rhizomes of HYPOXIS OBTUSA two monoglucosides having the same aglycone as hypoxoside, 1-(3',4'- dihydroxyphenyl)-5-(3'',4''-dihydroxyphenyl)-1-pen-ten-4-yne, have been obtained. By methylation followed by hydrogenation they have been transformed into the same compound, 1-(3'-methoxy-4'- O-beta- D-glucopyranos...

journal_title：Planta medica

authors： Galeffi C,Multari G,De Vicente Y,Messana I,Nicoletti M,Marini-Bettolo GB

更新日期：1989-06-01 00:00:00

abstract：:In a medium throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. With HPLC-based activity profiling in combination with on- and off-line spectroscopic metho...

journal_title：Planta medica

authors： Slusarczyk S,Zimmermann S,Kaiser M,Matkowski A,Hamburger M,Adams M

更新日期：2011-09-01 00:00:00

abstract：:Scopoletin exhibited an immediate and dose-dependent hypouricemic effect after intraperitoneal administration (50, 100, 200 mg/kg) in hyperuricemic mice induced by potassium oxonate; however, it did not affect the serum uric acid level in normal mice at the tested doses. For exploring the involved mechanisms of action...

journal_title：Planta medica

authors： Ding Z,Dai Y,Wang Z

更新日期：2005-02-01 00:00:00

abstract：:Esters of 13-hydroxylupanine and 4-hydroxylupanine with acetic, propionic, butyric, isobutyric, valeric, isovaleric, tiglic, benzoic, and TRANS-cinnamic acid have been synthesized and characterized by capillary gas-liquid chromatography and mass spectrometry (EI-MS, CI-MS). In LUPINUS POLYPHYLLUS, L. ALBUS, L. ANGUSTI...

journal_title：Planta medica

authors： Mühlbauer P,Witte L,Wink M

更新日期：1988-06-01 00:00:00

abstract：:The aerial parts of DODONAEA VISCOSA afforded a new diterpenoid, dodonic acid, the structure and stereochemistry of which have been established by chemical and spectroscopic means. ...

journal_title：Planta medica

authors： Sachdev K,Kulshreshtha DK

更新日期：1984-10-01 00:00:00

abstract：:Three new lycopodium alkaloids, 11alpha-hydroxyphlegmariurine B (2), 7alpha-hydroxyphlegmariurine B (3) and 7alpha,11alpha-dihydroxyphlegmariurine B (4) along with a known compound, phlegmariurine B (1), were isolated from the herb Huperzia serrata. The structures of the above compounds were elucidated based on spectr...

journal_title：Planta medica

authors： Tan CH,Wang BD,Jiang SH,Zhu DY

更新日期：2002-02-01 00:00:00

abstract：:In the extremely skin irritant and caustic latex of Excoecaria agallocha the major part of the polyfunctional diterpene esters (DTE) (group I) are aliphatic polyunsaturated 9,13,14-orthoesters of the daphnane-type parent alcohol 5 beta-hydroxyresiniferonol-6 alpha, 7 alpha-epoxide, esterified simultaneously in their 2...

journal_title：Planta medica

authors： Karalai C,Wiriyachitra P,Opferkuch HJ,Hecker E

更新日期：1994-08-01 00:00:00

abstract：:Two new sesquiterpenes, (E)-(2S,3S,6R)-atlantone-2,3-diol (1) and (E)-(2S,3S,6S)-atlantone-2,3,6-triol (2), along with two known sesquiterpenes, atlantolone (3) and (E)-α-atlantone (4), were isolated from Cedrus deodara Loud. The structures of the new compounds were elucidated on the basis of UV, IR, NMR, HR‑ESI-QTOF‑...

journal_title：Planta medica

authors： Chaudhary A,Sood S,Kaur P,Kumar N,Thakur A,Gulati A,Singh B

更新日期：2012-01-01 00:00:00

abstract：:Shoot primordia, which were able to propagate vegetatively with a very high rate and to redifferentiate easily to new plants, were induced from shoot tips of Stevia rebaudiana Bertoni on Gamborg B5 medium containing 6-benzylaminopurine (BAP) and alpha-naphthaleneacetic acid (NAA) under light. The propagation of the sh...

journal_title：Planta medica

authors： Miyagawa H,Fujioka N,Kohda H,Yamasaki K,Taniguchi K,Tanaka R

更新日期：1986-08-01 00:00:00

abstract：:Blue cohosh, Caulophyllum thalictroides (L.) Michx. is a popular herb, roots and rhizomes of which have been extensively used for women's health. Alkaloids and saponins are considered to be responsible for its pharmacological effects. In this investigation the methanolic extract of the roots of blue cohosh, the alkalo...

journal_title：Planta medica

authors： Madgula VL,Ali Z,Smillie T,Khan IA,Walker LA,Khan SI

更新日期：2009-03-01 00:00:00

abstract：:Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and...

journal_title：Planta medica

authors： Li HM,Tang YL,Zhang ZH,Liu CJ,Li HZ,Li RT,Xia XS

更新日期：2012-01-01 00:00:00

abstract：:EGFR, as a critical signaling pathway in many human tumors, has become an important target of cancer drug design. Taspine has shown meaningful angiogenesis activity in previous studies. This paper is to investigate the antitumor action of taspine by modulating the EGFR signaling pathway. The study determined the expre...

journal_title：Planta medica

authors： Zhang Y,Zheng L,Zhang J,Dai B,Wang N,Chen Y,He L

更新日期：2011-11-01 00:00:00

abstract：:Rice bran, a by-product of brown rice milling, is a rich source of dietary fiber and protein, and its usage as a functional food is expected to increase. In this study, immunomodulatory effects of glycoprotein obtained from rice bran were studied in normal mice and mouse models of cyclophosphamide-induced immunosuppre...

journal_title：Planta medica

authors： Park HY,Yu AR,Hong HD,Kim HH,Lee KW,Choi HD

更新日期：2016-05-01 00:00:00

abstract：:Three new β-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature...

journal_title：Planta medica

authors： Wansi JD,Happi EN,Bavoua JL,Devkota KP,Sewald N

更新日期：2012-01-01 00:00:00

abstract：:In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2) and the subsequent...

journal_title：Planta medica

authors： Schrutka-Rechtenstamm R,Kopp B,Löffelhardt W

更新日期：1985-10-01 00:00:00

abstract：:A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibit...

journal_title：Planta medica

authors： Zhang SD,Qin JJ,Jin HZ,Yin YH,Li HL,Yang XW,Li X,Shan L,Zhang WD

更新日期：2012-01-01 00:00:00

abstract：:The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced. The extract of the herb of Ch.majus als...

journal_title：Planta medica

authors： Vavrecková C,Gawlik I,Müller K

更新日期：1996-10-01 00:00:00

abstract：:An efficient in vitro propagation protocol for rapidly producing Cannabis sativa plantlets from young leaf tissue was developed. Using gas chromatography-flame ionization detection (GC-FID), high THC yielding elite female clone of a drug-type CANNABIS variety (MX) was screened and its vegetatively propagated clones we...

journal_title：Planta medica

authors： Lata H,Chandra S,Khan IA,Elsohly MA

更新日期：2010-10-01 00:00:00

abstract：:Aerial parts of Pterocaulon polystachyum from Chaco province, Argentina, afforded the known coumarins ayapin, isoscopoletin, prenyletin, prenyletin methyl ether, virgatenol, obtusinin, 5-methoxy-6,7-methylenedioxycoumarin, 5-(3,3-dimethylallyloxy)-6,7-methylenedioxycoumarin, 5-(2',3'-dihydroxy-3-methylbutanoxy)-6,7-me...

journal_title：Planta medica

authors： Vera N,Bardón A,Catalán CA,Gedris TE,Herz W

更新日期：2001-10-01 00:00:00

abstract：:Blood fluke of the genus Schistosoma are the etiological agents of human schistosomiasis, an important neglected tropical disease that afflicts over 200 million people worldwide. The treatment for this disease relies heavily on a single drug, praziquantel. Recent reports of praziquantel resistance raise concerns about...

journal_title：Planta medica

authors： Moraes Jd,Almeida AA,Brito MR,Marques TH,Lima TC,Sousa DP,Nakano E,Mendonça RZ,Freitas RM

更新日期：2013-03-01 00:00:00

abstract：:New protostane-type triterpenes, 11-deoxyalisol C and alisol D, have been isolated from the rhizomes of ALISMA PLANTAGO-AQUATICA, and their structures have been elucidated on the basis of spectral and chemical data. ...

journal_title：Planta medica

authors： Fukuyama Y,Pei-Wu G,Rei W,Yamada T,Nakagawa K

更新日期：1988-10-01 00:00:00

abstract：:Plant volatile organic compounds (volatiles) are secondary plant metabolites that play crucial roles in the reproduction, defence, and interactions with other vegetation. They have been shown to exhibit a broad range of biological properties and have been investigated for antimicrobial and anticancer activities. In ad...

journal_title：Planta medica

authors： Mun H,Townley HE

更新日期：2020-11-11 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection can result in oxidative stress through production of reactive oxygen species (ROS). Simultaneously, oxidative stress is able to activate the replication of virus and lead to the apoptosis of T lymphocytes which is the defense of the immune function. Ampelopsin, belonging to...

journal_title：Planta medica

authors： Ye J,Guan Y,Zeng S,Liu D

更新日期：2008-02-01 00:00:00

abstract：:Extracts from Bupleurum fruticescens were examined for oral and topical anti-inflammatory activities. The BuOH extract proved to be active against carrageenan and tetradecanoylphorbol acetate acute edemas and allowed the isolation of three saponins identified by spectroscopic techniques as 3 beta-O-(O-alpha-L-rhamnopy...

journal_title：Planta medica

authors： Just MJ,Recio MC,Giner RM,Cuéllar MJ,Máñez S,Bilia AR,Ríos JL

更新日期：1998-06-01 00:00:00

abstract：:Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. This study was conducted to investigate the efficacy of astilbin on experimental diabetic nephropathy (DN) in vivo and in vitro and its possible mechanisms. Astilbin was added in high glucose stimulated HK-2 cells, streptozotocin-indu...

journal_title：Planta medica

authors： Li GS,Jiang WL,Yue XD,Qu GW,Tian JW,Wu J,Fu FH

更新日期：2009-11-01 00:00:00

abstract：:Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1-10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NM...

journal_title：Planta medica

authors： Varughese T,Manir MM,Rahaman M,Kim JK,Lee BG,Moon SS

更新日期：2011-12-01 00:00:00