Abstract:
:Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1-10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NMR techniques along with IR and HR-TOF-MS. Rogchaponins R4 ( 4) and R5 (5) showed inhibitory activities against yeast alcohol dehydrogenase (ADH) with IC (50) values of 16.1 ± 3.2 and 15.4 ± 3.3 µM, respectively. A 4-methylpyrazole positive control exhibited an IC (50) of 2750 ± 50 µM. However, the saponins showed no inhibitory activity against yeast aldehyde dehydrogenase (ALDH).
journal_name
Planta Medjournal_title
Planta medicaauthors
Varughese T,Manir MM,Rahaman M,Kim JK,Lee BG,Moon SSdoi
10.1055/s-0031-1280024subject
Has Abstractpub_date
2011-12-01 00:00:00pages
2029-36issue
18eissn
0032-0943issn
1439-0221journal_volume
77pub_type
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