Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats.

abstract：:Five new triterpenoid saponins (1-5) and four known triterpenoid saponins, ginsenoside Re5 (6), majonoside R1 (7), 24(R)-majonoside R1 (8), and ginsenoside Rf (9), were isolated from the rhizomes of Panacis majoris. The structures of new compounds were elucidated as (20S,24S,25R*)-6-O-[β-D-glucopyranosyl-(1 → 2)-β-D-g...

journal_title：Planta medica

authors： Li M,Liu F,Jin YR,Wang XZ,Wu Q,Liu Y,Li XW

更新日期：2017-02-01 00:00:00

abstract：:Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available tre...

journal_title：Planta medica

authors： Mamede L,Ledoux A,Jansen O,Frédérich M

更新日期：2020-06-01 00:00:00

abstract：:The aim of this study was to investigate the effect of demethylbellidifolin (DMB), a major xanthone compound of Swertia davidi franch, on nitroglycerin (NTG) tolerance. In the in vivo portion of the study, pretreatment of Sprague-Dawley rats with NTG (10 mg/kg) for 8 days caused tolerance to the depressor effect of NT...

journal_title：Planta medica

authors： Shi RZ,Li XH,Jia SJ,Fu QM,Chen YR,Chen J,Chen A,Li SX,Tan GS,Li YJ,Zhang GG

更新日期：2009-11-01 00:00:00

abstract：:Three new azaphilones, chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3), and two new chlorinated phenolic glycosides, globosumoside A (4) and globosumoside B (5), were isolated from the crude extract of the fungal strain Chaetomium elatum No. 89-1-3-1. Their structures were determin...

journal_title：Planta medica

authors： Chen GD,Li YJ,Gao H,Chen Y,Li XX,Li J,Guo LD,Cen YZ,Yao XS

更新日期：2012-10-01 00:00:00

abstract：:Scutellariae Radix (SR), the root of Scutellaria baicalensis (Labiatae), is widely used in clinical Chinese medicine. In order to investigate the effect of SR on the absorption and disposition of cyclosporine, rats were administered with cyclosporine orally (in the form of the microemulsion Neoral and intravenously wi...

journal_title：Planta medica

authors： Lai MY,Hsiu SL,Hou YC,Tsai SY,Chao PD

更新日期：2004-02-01 00:00:00

abstract：:Ten new nervogenic acid derivatives (1-4, 6-11) and one known compound (5) have been isolated from Liparis nervosa. Their structures were determined using extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 3, 4, 9, 10, and 11 were evaluated for their cytotoxicity against A549, H460, Hela,...

journal_title：Planta medica

authors： Huang S,Zhou XL,Wang CJ,Wang HY,Wang YS,Shan LH,Weng J

更新日期：2013-03-01 00:00:00

abstract：:The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effec...

journal_title：Planta medica

authors： Efentakis P,Iliodromitis EK,Mikros E,Papachristodoulou A,Dagres N,Skaltsounis AL,Andreadou I

更新日期：2015-06-01 00:00:00

abstract：:Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...

journal_title：Planta medica

authors： Santhosh RS,Suriyanarayanan B

更新日期：2014-01-01 00:00:00

abstract：:It has been known that silymarin exhibits protective activity against oxidative liver injury induced by various hepatotoxicants, but the underlying mechanism of its beneficial action remains unclear. We determined the alterations in sulfur-containing amino acid metabolism induced by silymarin in association with its e...

journal_title：Planta medica

authors： Kwon DY,Jung YS,Kim SJ,Kim YS,Choi DW,Kim YC

更新日期：2013-08-01 00:00:00

abstract：:Paeoniae Radix (the roots of Paeonia lactiflora Pallas) is a crude drug that is used in Asia and Europe to improve blood flow. We studied its vasodilator effect and mechanisms of action in vitro. The extract from Paeoniae Radix (PRE) relaxed prostaglandin F2a-precontracted aortic ring preparations of isolated rat aort...

journal_title：Planta medica

authors： Goto H,Shimada Y,Akechi Y,Kohta K,Hattori M,Terasawa K

更新日期：1996-10-01 00:00:00

abstract：:Three new β-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature...

journal_title：Planta medica

authors： Wansi JD,Happi EN,Bavoua JL,Devkota KP,Sewald N

更新日期：2012-01-01 00:00:00

abstract：:Croton caudatus is an important species in Dai folk medicine. Some other Croton species, in particular, C. kongensis, C. cascarilloides, C. crassifolius, C. lachnocarpus and C. olivaceus are often marketed as C. caudatus, and thus, the therapeutic effects of C. caudatus are not achieved. The respective morphological f...

journal_title：Planta medica

authors： Xue HG,Zhou SD,He XJ,Yu Y

更新日期：2007-06-01 00:00:00

abstract：:Electrospray ionization mass spectrometry (ESI-MS) combined with multiple tandem mass spectrometry (MS (n)) has been applied for simultaneously determining lipo-alkaloids from the aconite tubers. ESI-MS can give a very good mass separation for lipo-alkaloid mixture and MS (n) can provide structural information. Accord...

journal_title：Planta medica

authors： Sun W,Song F,Cui M,Liu S

更新日期：1999-06-01 00:00:00

abstract：:Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance for the Pacific Islanders. Kava is also sold as a herbal supplement or recreational beverage consumed for its mild inebriating effect in Europe and North America. With a...

journal_title：Planta medica

authors： Liu Y,Lund JA,Murch SJ,Brown PN

更新日期：2018-11-01 00:00:00

abstract：:Baicalein, berberine, curcumin and hesperidin are the major components derived from Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata, respectively. These plants have been used for the treatment of diverse chronic inflammatory diseases including respiratory disease in oriental medicine an...

journal_title：Planta medica

authors： Lee CJ,Lee JH,Seok JH,Hur GM,Park YC,Seol IC,Kim YH

更新日期：2003-06-01 00:00:00

abstract：:VERATRUM CALIFORNICUM (Liliaceae) is an important monocotyledonous medicinal plant which is the only source of the anticancer compound cyclopamine. An IN VITRO culture system for somatic embryogenesis and green plant regeneration of VERATRUM CALIFORNICUM was developed. Embryogenic calli were induced from mature embryo...

journal_title：Planta medica

authors： Ma R,Ritala A,Oksman-Caldentey KM,Rischer H

更新日期：2006-10-01 00:00:00

abstract：:The effects of gallic acid on the gene expressions of inducible nitric oxide synthase (iNOS) and the cytokines interleukin (IL)-1, IL-10, IL-12, IL-18, TNF-alpha, and interferon (IFN)-gamma were investigated by reverse-transcription polymerase chain reaction (RT-PCR). The experiments were performed in parallel in non-...

journal_title：Planta medica

authors： Radtke OA,Kiderlen AF,Kayser O,Kolodziej H

更新日期：2004-10-01 00:00:00

abstract：:The present study investigated the role of adenosine in the stimulatory action of paeoniflorin on in vitro glucose transport. Paeoniflorin increased the uptake of a radiolabeled, non-metabolizable glucose derivative into isolated white adipocytes of Wistar rat in a concentration-dependent manner and this action was ab...

journal_title：Planta medica

authors： Tang LM,Liu IM,Cheng JT

更新日期：2003-04-01 00:00:00

abstract：:From the rhizome of Zingiber officinale L. (Zingiberaceae), four shogaols that protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25 - 35) insult at EC50 = 4.5 - 81 microM were isolated. The efficacy of cell protection from beta-amyloid(25 - 35) insult by these shogao...

journal_title：Planta medica

authors： Kim DS,Kim DS,Oppel MN

更新日期：2002-04-01 00:00:00

abstract：:The ether fraction of the defatted ethanol extract of the aerial parts of Caralluma penicillata (defl) M. E. Br. (Asclepiadaceae) yielded four new oxypregnane glycosides, penicillosides D-G. The structures of the isolated compounds were established by different spectroscopic methods. ...

journal_title：Planta medica

authors： Abdel-Sattar E,Meselhy MR,Al-Yahya MA

更新日期：2002-05-01 00:00:00

abstract：:Several synthetic aromatase inhibitors are currently in clinical use for the treatment of postmenopausal women with hormone-receptor positive breast cancer. However, these treatments may lead to untoward side effects and so the search for new aromatase inhibitors continues, especially those for which the activity is p...

journal_title：Planta medica

authors： Balunas MJ,Kinghorn AD

更新日期：2010-08-01 00:00:00

abstract：:In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2) and the subsequent...

journal_title：Planta medica

authors： Schrutka-Rechtenstamm R,Kopp B,Löffelhardt W

更新日期：1985-10-01 00:00:00

abstract：:Two new secodammarane triterpenoid saponins were isolated from the leaves of Cyclocarya paliurus. Based on chemical and spectral analysis they were assigned as (20S)-20-hydroxy-24-O-alpha-L-arabino-pyranosyl-3,4- secodammar-4(28),11,25-trien-3-oic acid, named cyclocarioside II and 25-hydroxy-(20S,24R)-epoxy-12R-O-beta...

journal_title：Planta medica

authors： Shu RG,Xu CR,Li LN,Yu ZL

更新日期：1995-12-01 00:00:00

abstract：:Capillary GC, GC-MS, IR, GC-IR, (1)H- and (13)C-NMR studies of the essential oil from the leaves and cones of ELSHOLTZIA POLYSTACHYA collected from two different locations in India revealed that one oil contained 1,8-cineol (37.3%), the other one perillene (61.2%) as the main constituent. ...

journal_title：Planta medica

authors： Mathela CS,Melkani AB,Bisht JC,Pant AK,Bestmann HJ,Erler J,Kobold U,Rauscher J,Vostrowsky O

更新日期：1992-08-01 00:00:00

abstract：:Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2 S,5' R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybo...

journal_title：Planta medica

authors： Xia X,Li Q,Li J,Shao C,Zhang J,Zhang Y,Liu X,Lin Y,Liu C,She Z

更新日期：2011-10-01 00:00:00

abstract：:Natural products can exhibit many beneficial effects on human health. As far as cancer is concerned, naturally occurring compounds have been reported to prevent tumorigenesis and also to suppress the growth of established tumors. As cancer cells have evolved multiple mechanisms to resist the induction of programmed ce...

journal_title：Planta medica

authors： Fulda S

更新日期：2010-08-01 00:00:00

abstract：:Orosunol and 8-demethylorosunol, two new 1-aryl-2,3-naphthalide lignans, have been isolated from Justicia flava root. Structures IV and V respectively have been proposed for them by spectral (UV, IR, PMR, (13)C NMR, and MS) and chemical evidence. ...

journal_title：Planta medica

authors： Olaniyi AA

更新日期：1982-03-01 00:00:00

abstract：:Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on insulin binding to isolated adipocytes. Administration of ganoderan B elicited significant increases of the activities of hepatic glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase, decreased ...

journal_title：Planta medica

authors： Hikino H,Ishiyama M,Suzuki Y,Konno C

更新日期：1989-10-01 00:00:00

abstract：:A plant mixture containing extracts of Nigella sativa possesses blood glucose lowering effects, but the direct antidiabetic effect of Nigella sativa is not yet established. Therefore, the effect of Nigella sativa oil (NSO) on blood glucose concentrations was studied in streptozotocin diabetic rats. In addition, the ef...

journal_title：Planta medica

authors： El-Dakhakhny M,Mady N,Lembert N,Ammon HP

更新日期：2002-05-01 00:00:00

abstract：:Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapont...

journal_title：Planta medica

authors： Jo SP,Kim JK,Lim YH

更新日期：2014-08-01 00:00:00