Abstract:
:Three new β-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature information. The alkaloids 9-11 were isolated for the first time from this genus. All compounds were tested for their activity against bacteria, fungi, and plant pathogen oomycetes using the paper disk agar diffusion assay. The agar diffusion test gave only low antimicrobial activities, corresponding to MICs > 1 mg/mL. However, compounds 1-4 and 11 exhibited a strong suppressive effect on phagocytosis response upon activation with serum opsonized zymosan in the range of IC(50) = 2.6-6.5 µM, while low cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3 was observed with IC(50) values ranging from 22.9 to 39.4 µM.
journal_name
Planta Medjournal_title
Planta medicaauthors
Wansi JD,Happi EN,Bavoua JL,Devkota KP,Sewald Ndoi
10.1055/s-0031-1280227subject
Has Abstractpub_date
2012-01-01 00:00:00pages
71-5issue
1eissn
0032-0943issn
1439-0221journal_volume
78pub_type
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