Effects of the olive tree leaf constituents on myocardial oxidative damage and atherosclerosis.

Abstract:

:The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effects. The pathogenesis of certain common diseases, including those of the cardiovascular system, involves oxidative stress and tissue inflammation. Olive polyphenolic compounds, such as oleuropein, hydroxytyrosol, or tyrosol, possess antioxidant, anti-inflammatory, antiatherosclerotic, anti-ischemic, and hypolipidemic effects on the myocardium as demonstrated by various in vitro and in vivo studies. In this review article, we summarize the current knowledge on the role of the olive leaf constituents in the prevention of cardiac dysfunction and highlight future perspectives in their use as cardioprotective agents in therapeutics.

journal_name

Planta Med

journal_title

Planta medica

authors

Efentakis P,Iliodromitis EK,Mikros E,Papachristodoulou A,Dagres N,Skaltsounis AL,Andreadou I

doi

10.1055/s-0035-1546017

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

648-54

issue

8

eissn

0032-0943

issn

1439-0221

journal_volume

81

pub_type

杂志文章,评审
  • Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity.

    abstract::Since the beginning of this century, Goji berries and juice are being sold as health food products in western countries and praised in advertisements and in the media for well-being and as an anti-aging remedy. The popularity of Goji products has rapidly grown over the last years thanks to efficient marketing strategi...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1186218

    authors: Potterat O

    更新日期:2010-01-01 00:00:00

  • Activity on the central nervous system of Himanthalia elongata.

    abstract::We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959655

    authors: Anca JM,Lamela M,Calleja JM

    更新日期:1993-06-01 00:00:00

  • Studies on the antihyperlipidemic properties of Averrhoa bilimbi fruit in rats.

    abstract::Averrhoa bilimbi Linn. fruit and its extracts were screened for antihypercholesterolemic activity using Triton-induced hypercholesterolemia in rats as a model. The fruit and its water extract, but not alcohol and hexane extracts, showed remarkable antihypercholesterolemic activity. An active fraction, which showed act...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0028-1088361

    authors: Ambili S,Subramoniam A,Nagarajan NS

    更新日期:2009-01-01 00:00:00

  • Dermal pharmacokinetics of Terpinen-4-ol following topical administration of Zingiber cassumunar (plai) oil.

    abstract::The purpose of this study was to investigate dermal pharmacokinetics of terpinen-4-ol in rats following topical administration of plai oil derived from the rhizomes of Zingiber cassumunar Roxb. Unbound terpinen-4-ol concentrations in dermal tissue were measured by microdialysis. The dermal pharmacokinetic study of ter...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1315262

    authors: Chooluck K,Singh RP,Sathirakul K,Derendorf H

    更新日期:2012-11-01 00:00:00

  • Protective effect of saponins from Panax notoginseng against doxorubicin-induced cardiotoxicity in mice.

    abstract::The dried rhizome of Panax notoginseng is a traditional Chinese herb extensively used for treatment of cardiovascular diseases and other ailments. Panax notoginseng saponins (PNS) are known as the major pharmacologically active constituents. The purpose of this study was to investigate the cardioprotective effects of ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034303

    authors: Liu L,Shi R,Shi Q,Cheng Y,Huo Y

    更新日期:2008-02-01 00:00:00

  • Stimulatory effect of paeoniflorin on adenosine release to increase the glucose uptake into white adipocytes of Wistar rat.

    abstract::The present study investigated the role of adenosine in the stimulatory action of paeoniflorin on in vitro glucose transport. Paeoniflorin increased the uptake of a radiolabeled, non-metabolizable glucose derivative into isolated white adipocytes of Wistar rat in a concentration-dependent manner and this action was ab...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-38878

    authors: Tang LM,Liu IM,Cheng JT

    更新日期:2003-04-01 00:00:00

  • Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1.

    abstract::Usnic acid, a lichen secondary metabolite produced by a whole number of lichens, has attracted the interest of researchers owing to its broad range of biological activity, including antiviral, antibiotic, anticancer properties, and it possessing a certain toxicity. The synthesis of new usnic acid derivatives and the i...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-0681-7069

    authors: Dyrkheeva N,Luzina O,Filimonov A,Zakharova O,Ilina E,Zakharenko A,Kuprushkin M,Nilov D,Gushchina I,Švedas V,Salakhutdinov N,Lavrik O

    更新日期:2019-01-01 00:00:00

  • Developmental studies of Artemisia annua: flowering and artemisinin production under greenhouse and field conditions.

    abstract::Cuttings of a clone of A. annua L. (Asteraceae), grown under 16 h photoperiod for 55 days were transferred to six photoperiod treatments in the greenhouse. Under short photoperiods (8, 10, or 12 h), plants flowered after two weeks; plants under long photoperiods (16, 20, or 24 h) remained vegetative until termination ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958040

    authors: Ferreira JF,Simon JE,Janick J

    更新日期:1995-04-01 00:00:00

  • Protective Effects of Bacopa Monnieri on Hydrogen Peroxide and Staurosporine: Induced Damage of Human Neuroblastoma SH-SY5Y Cells.

    abstract::Many herbs, and recently their biomass from in vitro cultures, are essential for the treatment of diseases. The aim of this study was to determine the optimal growth of Bacopa monnieri (water hyssop) in an in vitro culture and to examine if extracts of the B. monnieri biomass from the in vitro culture would affect hyd...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0035-1558166

    authors: Łojewski M,Pomierny B,Muszyńska B,Krzyżanowska W,Budziszewska B,Szewczyk A

    更新日期:2016-02-01 00:00:00

  • Depsides from the petals of Papaver rhoeas.

    abstract::Two new depsides as well as the known p-hydroxybenzoic acid and its methyl ester, protocatechuic acid, 2-(4-hydroxyphenyl)-ethanol, 2-(3,4-dihydroxyphenyl)-ethanol and the flavonoids kaempferol, quercetin, luteolin and hypolaetin and the glycosides 3- O-beta- D-glucopyranosylquercetin (isoquercitrine), 3- O-beta- D-gl...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2004-818956

    authors: Hillenbrand M,Zapp J,Becker H

    更新日期:2004-04-01 00:00:00

  • Antioxidant lignans from Mananthes patentiflora.

    abstract::A new tetrahydrofuranoketone lignan (1) and two new tetrahydrofuranoketone lignan glycosides (2, 3) were isolated from the ethanol extract of the aerial part of Mananthes patentiflora. The structure elucidations of these compounds were mainly established on the basis of 1D, 2D NMR and HR-mass spectroscopic analysis. A...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185356

    authors: Tian J,Yang X,Di Y,Ma Y,Li L,Li L,He H,Hao X

    更新日期:2009-04-01 00:00:00

  • Small-molecule STAT3 signaling pathway modulators from Polygonum cuspidatum.

    abstract::Constitutively activated STAT3 plays a pivotal role in oncogenesis and metastasis in many human cancers, and STAT3 has been validated as a novel anticancer drug target. Thus, the identification of small molecules that modulate STAT3 activity could be of great therapeutic importance. The aim of this study was to isolat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1315121

    authors: Liu J,Zhang Q,Chen K,Liu J,Kuang S,Chen W,Yu Q

    更新日期:2012-09-01 00:00:00

  • Cratoxylum formosum Extract Protects against Amyloid-Beta Toxicity in a Caenorhabditis elegans Model of Alzheimer's Disease.

    abstract::Amyloid-β, one of the hallmarks of Alzheimer's disease, is toxic to neurons and causes cell death in the brain. Oxidative stress is known to play an important role in Alzheimer's disease, and there is strong evidence linking oxidative stress to amyloid-β. The herbal plant "Tiew kon" (Cratoxylum formosum ssp. pruniflor...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0041-111621

    authors: Keowkase R,Weerapreeyakul N

    更新日期:2016-04-01 00:00:00

  • Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity.

    abstract::Extracts from Pygeum africanum, Serenoa repens and Cucurbita pepo are used in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The activity of the androgen receptor (AR) is known to control growth of the prostate. Here, we examined extracts of these plants for their antiandrogenic activit...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-946638

    authors: Schleich S,Papaioannou M,Baniahmad A,Matusch R

    更新日期:2006-07-01 00:00:00

  • Alkaloids from Hippeastrum equestre. Part I. Phamine, a new phenanthridone alkaloid.

    abstract::From the bulbs of Vietnamese Hippeastrum equestre Herb. (Amaryllidaceae), besides the well known alkaloids lycorine, tazettine, and hippeastrine, a new alkaloid, phamine, has been isolated. Its structure was established by spectroscopic methods. ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-959375

    authors: Döpke W,Pham LH,Gründemann E,Bartoszek M,Flatau S

    更新日期:1995-12-01 00:00:00

  • Plants: a source for new antimycobacterial drugs.

    abstract::Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1350978

    authors: Santhosh RS,Suriyanarayanan B

    更新日期:2014-01-01 00:00:00

  • Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction.

    abstract::Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In danggui buxue tang, the complete functions of astragali radix require the assistance of Angelicae sinensis radix, and both he...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0033-1360314

    authors: Zheng KY,Zhang ZX,Du CY,Zhang WL,Bi CW,Choi RC,Dong TT,Tsim KW

    更新日期:2014-02-01 00:00:00

  • New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata.

    abstract::As part of a study on chemical constituents of Camptotheca species, one new natural camptothecin analogue (2), two new alkaloids (3, 4), one new ellagic acid analogue (5), and 19 known compounds (1, 6-23) have been isolated from the root bark, stem bark, fruits, and leaves of Camptotheca acuminata Decaisne. The struct...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2004-835854

    authors: Zhang Z,Li S,Zhang S,Liang C,Gorenstein D,Beasley RS

    更新日期:2004-12-01 00:00:00

  • Two new derivatives of griseofulvin from the mangrove endophytic fungus Nigrospora sp. (strain No. 1403) from Kandelia candel (L.) Druce.

    abstract::Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2 S,5' R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybo...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1271040

    authors: Xia X,Li Q,Li J,Shao C,Zhang J,Zhang Y,Liu X,Lin Y,Liu C,She Z

    更新日期:2011-10-01 00:00:00

  • New Cardiac Glycosides from Digitalis lanata.

    abstract::From the leaves of DIGITALIS LANATA Ehrh. two new Cardenolides have been found and structurally elucidated as Digoxigenin-3-O-beta- D-digitoxosido-beta- D-digitoxosido-beta- D-xyloside bei TLC and spectroscopic methods. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969697

    authors: Krüger D,Wichtl M

    更新日期:1984-06-01 00:00:00

  • Chemical Study on the Alkaloids of Corydalis hsuchowensis.

    abstract::Ten alkaloids were isolated from the bulb of CORYDALIS HSUCHOWENSIS W. Y. Lian nov. ined. Among them nine alkaloids are known, identified as (-)-stylopine ( 1), cheilanthifoline ( 2), (+)-adlumidine ( 3), (+)-bicuculline ( 4), sibiricine ( 5), humosine A ( 6), (+)-bulbocapnine ( 7), (-)-scoulerine ( 8), and protopine ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960054

    authors: Zhou JY,Tong XJ,Lian WY,Fang QC

    更新日期:1991-04-01 00:00:00

  • New naphthalenyl glycosides from the roots of Juglans mandshurica.

    abstract::Three new glycosides, 1,4,8-trihydroxynaphthalene-1-O-D-glucopyranosyl-(1-->6)-beta-D- xylopyranoside (1), 1,4,8-trihydroxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)-alph a-L- arabinopyranoside (2), 1-hydroxy-4-methoxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)- alpha-L-rhamnopyranoside (3), were isolated from th...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-0029-1243129

    authors: Lee SW,Lee KS,Son JK

    更新日期:2000-03-01 00:00:00

  • Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies.

    abstract::Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted t...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0043-104933

    authors: Santana MT,Cercato LM,Oliveira JP,Camargo EA

    更新日期:2017-05-01 00:00:00

  • Hypoglycaemic activity of dioscoretine from tubers of Dioscorea dumetorum in normal and alloxan diabetic rabbits.

    abstract::Dioscoretine isolated from the aqueous fraction of the methanol extract of Dioscorea dumetorum tubers when administered intra-peritoneally to normal and alloxan diabetic rabbits produces significant hypoglycaemic effects at a dose of 20 mg/kg. The fasting blood sugar in normoglycaemic rabbits was reduced from 112 mg/1...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960952

    authors: Iwu MM,Okunji CO,Ohiaeri GO,Akah P,Corley D,Tempesta MS

    更新日期:1990-06-01 00:00:00

  • Phenolic Compounds as Arginase Inhibitors: New Insights Regarding Endothelial Dysfunction Treatment.

    abstract::Endothelial dysfunction is characterised by the low bioavailability of nitric oxide with a relevant negative impact on the nitric oxide/cGMP pathway. The loss of nitric oxide/cGMP signaling may be caused by an increased arginase activity. Plant-derived substances, especially polyphenols, are compounds that have the po...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0044-100398

    authors: Minozzo BR,Fernandes D,Beltrame FL

    更新日期:2018-03-01 00:00:00

  • Biochanin A, the Most Potent of 16 Isoflavones, Induces Relaxation of the Coronary Artery Through the Calcium Channel and cGMP-dependent Pathway.

    abstract::The dietary intake of flavonoids seems to be inversely related to cardiovascular mortality. The consumption of isoflavonoids is increasing in the general population, especially due to the use of food supplements and a variety of isoflavonoid-rich foods. However, detailed studies on the vascular influence of individual...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1158-9422

    authors: Migkos T,Pourová J,Vopršalová M,Auger C,Schini-Kerth V,Mladěnka P

    更新日期:2020-07-01 00:00:00

  • The sedative effects and mechanism of action of cedrol inhalation with behavioral pharmacological evaluation.

    abstract::It has been reported that cedarwood oil has sedative effects when inhaled. In this study, we evaluated sedative effects of inhaled cedrol, which is a major component of cedarwood oil. Accumulative spontaneous motor activity was significantly decreased in the cedrol-exposed Wistar rats. Similar results were confirmed i...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-41114

    authors: Kagawa D,Jokura H,Ochiai R,Tokimitsu I,Tsubone H

    更新日期:2003-07-01 00:00:00

  • Anti-herpetic properties of hydroalcoholic extracts and pressed juice from Echinacea pallida.

    abstract::Hydroalcoholic extracts and pressed juice from Echinacea pallida were phytochemically characterised by HPLC-MS analyses. Ferulic and caffeic acid derivatives were identified as major constituents. All tested extracts and pressed juice from Echinacea pallida exhibited a low cytotoxic activity on monkey kidney cells in ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1186137

    authors: Schneider S,Reichling J,Stintzing FC,Messerschmidt S,Meyer U,Schnitzler P

    更新日期:2010-02-01 00:00:00

  • Identification of an anti-inflammatory principle from the stem bark of Millettia versicolor.

    abstract::The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-42794

    authors: Fotsing MT,Yankep E,Njamen D,Fomum ZT,Nyasse B,Bodo B,Recio MC,Giner RM,Ríos JL

    更新日期:2003-08-01 00:00:00

  • Prenylisoflavonoids from Erythrina senegalensis as novel HIV-1 protease inhibitors.

    abstract::Eight compounds were isolated from the CH (2)Cl (2) extracts of ERYTHRINA SENEGALENSIS to assess HIV-1 protease (PR) activity inhibition. The prenylated isoflavone structures, identified by spectroscopic analysis, were 8-prenylluteone ( 1), auriculatin ( 2), erysenegalensein O ( 3), erysenegalensein D ( 4), erysenegal...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0028-1088395

    authors: Lee J,Oh WK,Ahn JS,Kim YH,Mbafor JT,Wandji J,Fomum ZT

    更新日期:2009-02-01 00:00:00