Biochanin A, the Most Potent of 16 Isoflavones, Induces Relaxation of the Coronary Artery Through the Calcium Channel and cGMP-dependent Pathway.

abstract：:The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times low...

journal_title：Planta medica

authors： Steverding D,Pemberton AJ,Royle H,Spackman RW,Rivett AJ

更新日期：2006-06-01 00:00:00

abstract：:Many anti-inflammatory agents are known to significantly enhance the terminal differentiation of some cancer cells such as leukemia cells. In this study, the effect of yomogin, a eudesmane sesquiterpene lactone isolated from Artemisia princeps with anti-inflammatory activity, was investigated in human promyelocytic le...

journal_title：Planta medica

authors： Kim SH,Kim TS

更新日期：2002-10-01 00:00:00

abstract：:Ocimum tenuiflorum has been widely used in traditional medicine and has high medicinal value. High volume trade of this potential medicinal plant species led to unscrupulous adulteration of both crude drugs as well as formulations. Morphology-based authentication is difficult in cases of incomplete or damaged samples ...

journal_title：Planta medica

authors： Kumar A,Rodrigues V,Mishra P,Baskaran K,Shukla AK,Shasany AK,Sundaresan V

更新日期：2018-01-01 00:00:00

abstract：:Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3-12 mg/kg p.o. x 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the ...

journal_title：Planta medica

authors： Visen PK,Shukla B,Patnaik GK,Dhawan BN

更新日期：1993-02-01 00:00:00

abstract：:Four new neolignan glucosides, longiflorosides A, B, C and D, in addition to one known neolignan glucoside, dehydro-diconiferyl alcohol-4-O-beta-D-glucopyranoside were obtained from whole plants of Pedicularis longiflora. The structures of these compounds were determined mainly on spectral evidence. ...

journal_title：Planta medica

authors： Wang CZ,Jia ZJ

更新日期：1997-06-01 00:00:00

abstract：:The aerial parts of JUNGIA SETERIANA afforded in addition to known compounds two pairs of isomeric C (17)-acetylenes which differ in the number of triple bonds and in the configuration of the 9,10-double bond. The structures and configurations followed from the UV and the (1)H-NMR spectra, especially from those of the...

journal_title：Planta medica

authors： Bohlmann F,Zdero C,King RM,Robinson H

更新日期：1984-04-01 00:00:00

abstract：:Propolis is a cereus resin with a complex chemical composition that possesses a wide range of biological activities. The aim of this study was to evaluate the in vitro anti-Giardia lamblia activity of Sonoran propolis collected from three different areas of Sonoran Desert in northwestern Mexico (Caborca, Pueblo de Ala...

journal_title：Planta medica

authors： Alday-Provencio S,Diaz G,Rascon L,Quintero J,Alday E,Robles-Zepeda R,Garibay-Escobar A,Astiazaran H,Hernandez J,Velazquez C

更新日期：2015-06-01 00:00:00

abstract：:An analytical method using HPLC with UV detection was developed to investigate the quassinoid content of Eurycoma longifolia Jack (Simaroubaceae) collected from various sources. Eurycomanone (1), longilactone (2), 14,15beta-dihydroxyklaineanone (3), 15beta-acetyl-14-hydroxyklaineanone (4), 6alpha-hydroxyeurycomalacton...

journal_title：Planta medica

authors： Chan KL,Choo CY,Morita H,Itokawa H

更新日期：1998-12-01 00:00:00

abstract：:Agastache mexicana is a plant in high demand that has long been used in Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid and acacetin were isolated and identified as two possible active compounds of A. mexicana aerial parts. An antinociceptive response was demons...

journal_title：Planta medica

authors： González-Trujano ME,Ventura-Martínez R,Chávez M,Díaz-Reval I,Pellicer F

更新日期：2012-05-01 00:00:00

abstract：:Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedat...

journal_title：Planta medica

authors： Lanhers MC,Fleurentin J,Dorfman P,Mortier F,Pelt JM

更新日期：1991-06-01 00:00:00

abstract：:Based on the inhibition of Cu(2+)-induced LDL oxidation as marker, the major antioxidants in the fruits of Forsythia suspensa and the stems of Magnolia coco were identified. Of these bioactive tetrahydrofurofuran lignans, pinoresinol, phillygenin, and syringaresinol were more potent than probucol. Sesamin and fargesin...

journal_title：Planta medica

authors： Chen CC,Chen HY,Shiao MS,Lin YL,Kuo YH,Ou JC

更新日期：1999-12-01 00:00:00

abstract：:The flowers of ARNICA MOLLIS afforded, in addition to baileyin ( 1A), baileyin acetate ( 1B), xanthalongin ( 3), and 2-deacetoxy-11alpha,13-dihydroxanthuminol ( 6), the new 1,5- CIS-guaianolides arnimollin acetate ( 2A) and arnimollin tiglinate ( 2A) and the new xanthanolides 11beta3,13-dihydroxanthalongin ( 4) and 11...

journal_title：Planta medica

authors： Marcinek-Hüpen-Bestendonk C,Willuhn G,Steigel A,Wendisch D,Middelhauve B,Wiebcke M,Mootz D

更新日期：1990-02-01 00:00:00

abstract：:Crocin is a pharmacologically active component of Crocus sativus. It is an unusual water-soluble carotenoid responsible for the red color of saffron. In various studies, the anticancer effect of saffron and its constituents has been established. Polyethylene glycolated nanoliposomes with a size range up to 200 nm are ...

journal_title：Planta medica

authors： Rastgoo M,Hosseinzadeh H,Alavizadeh H,Abbasi A,Ayati Z,Jaafari MR

更新日期：2013-04-01 00:00:00

abstract：:At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in...

journal_title：Planta medica

authors： Petit C,Bujard A,Skalicka-Woźniak K,Cretton S,Houriet J,Christen P,Carrupt PA,Wolfender JL

更新日期：2016-03-01 00:00:00

abstract：:In this study the skin permeation and the topical anti-inflammatory properties of ginger extracts were investigated. A commercial ginger dry extract (DE) and a gingerols-enriched dry extract (EDE) were evaluated for their in vivo topical anti-inflammatory activity by inhibition of Croton oil-induced ear oedema in mice...

journal_title：Planta medica

authors： Minghetti P,Sosa S,Cilurzo F,Casiraghi A,Alberti E,Tubaro A,Loggia RD,Montanari L

更新日期：2007-12-01 00:00:00

abstract：:The seed pods of Erythrina latissima yielded erysotrine, erysodine, syringaresinol, vanillic acid, a new erythrina alkaloid, (+)-10,11-dioxoerysotrine, which was lethal to brine shrimp and 2-(5'-hydroxy-3'-methoxy phenyl)-6-hydroxy-5-methoxybenzofuran, which showed strong antimicrobial activity against the yeast spore...

journal_title：Planta medica

authors： Wanjala CC,Juma BF,Bojase G,Gashe BA,Majinda RR

更新日期：2002-07-01 00:00:00

abstract：:From the leaves of BLUMEA ARFAKIANA Martelli (Asteraceae), used in traditional medicine in Papua New Guinea, besides stigmasterol and beta-eudesmol, four graniline esters ( 1-4) have been isolated. Furthermore, blumealactone C ( 5), deacetylblumealactone C ( 6), and deoxyblumealactone C ( 7) have been identified. ...

journal_title：Planta medica

authors： Rücker G,Paulini G,Sakulas H,Lawong B,Goeltenboth F

更新日期：1991-06-01 00:00:00

abstract：:Olive oil has been shown to exhibit beneficial effects in the prevention of cardiovascular diseases although its molecular mechanism still remains unclear. In the present study, we investigated the effect of hydroxytyrosol (HT), a major phenolic component in olive oil and leaves from OLEA EUROPAEA L. (Oleaceae family...

journal_title：Planta medica

authors： Zrelli H,Matsuka M,Araki M,Zarrouk M,Miyazaki H

更新日期：2011-10-01 00:00:00

abstract：:The studies were carried out to evaluate the constituents in the aerial part of Aconitum chiisanense (Ranunculaceae). From the butanol fraction of the methanol extract, kaempferol 3- O-beta-glucopyranoside-7- O-(6-trans-caffeoyl)-beta-glucopyranosyl-(1-->2)-alpha-rhamnopyranoside (I), quercetin 3- O-beta-glucopyranosi...

journal_title：Planta medica

authors： Jeong HJ,Whang WK,Kim IH

更新日期：1997-08-01 00:00:00

abstract：:New phloroglucinol derivatives were isolated from the ethanolic extract of ECKLONIA MAXIMA, a brown alga found off the west coast of South Africa. Most of these compounds contain dibenzo[1,4]dioxin elements. The common basic unit of all the compounds found is eckol, a hexahydroxyphenoxydibenzo[1,4]dioxin composed of 3...

journal_title：Planta medica

authors： Glombitza KW,Vogels HP

更新日期：1985-08-01 00:00:00

abstract：:Isovitexin exhibits potent antioxidant activities. In this study, the activity of nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages after incubation with isovitexin was investigated. Isovitexin was able to reduce the production of hydrogen peroxide induced by LPS in mouse macropha...

journal_title：Planta medica

authors： Lin CM,Huang ST,Liang YC,Lin MS,Shih CM,Chang YC,Chen TY,Chen CT

更新日期：2005-08-01 00:00:00

abstract：:This perspective describes some commonly used animal models for the evaluation of potential chemopreventive agents in colon carcinogenesis. Special emphasis is given to the azoxymethane (AOM)/1,2-dimethylhydrazine (DMH) rat model and APCMIN mice, carrying a mutation in APC, a key gene in human carcinogenesis. In the A...

journal_title：Planta medica

authors： Femia AP,Caderni G

更新日期：2008-10-01 00:00:00

abstract：:From the water extract of the roots of Urtica dioica (stinging nettle) a polysaccharide fraction was isolated which revealed activity in the carrageenan rat paw edema model and lymphocyte transformation test. Ion exchange chromatography and gel filtration of this fraction afforded 4 different polysaccharides, one of w...

journal_title：Planta medica

authors： Wagner H,Willer F,Kreher B

更新日期：1989-10-01 00:00:00

abstract：:Two phenolic triterpenoids, pristimerol (30 µg/mL) and 8- EPI-6-deoxoblepharodol (20 µg/mL), obtained by catalytic reduction of pristimerin, exhibited bacteriostatic action against Staphylococcus epidermidis. This activity was not dependent on the inoculum size and the growth phase although it showed a stronger effect...

journal_title：Planta medica

authors： López MR,de León L,Moujir L

更新日期：2011-05-01 00:00:00

abstract：:Bioactivity-directed separation led to the identification of four compounds, viz. denbinobin (1), 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2), 3-methylgigantol (3), and erianthridin (4) from the ethanolic extract of Ephemerantha lonchophylla. Antiplatelet tests were carried out using 4 different aggregation inducers, ...

journal_title：Planta medica

authors： Chen CC,Huang YL,Teng CM

更新日期：2000-05-01 00:00:00

abstract：:The content of ursolic acid and oleanolic acid was determined in different plant parts of two Glechoma species, G. hederacea and G. hirsuta. To achieve optimal extraction conditions of ursolic acid and oleanolic acid from plant material, several methods including maceration, heat reflux, Soxhlet, and ultrasonic extrac...

journal_title：Planta medica

authors： Grabowska K,Żmudzki P,Wróbel-Biedrawa D,Podolak I

更新日期：2021-01-15 00:00:00

abstract：:Novel therapies are needed to address the public health problem posed by methicillin-resistant STAPHYLOCOCCUS AUREUS (MRSA). In this study, we determined the effects of combinations of antibiotics and plant polyphenols against 20 clinical isolates of MRSA. The IN VITRO activities of 10 antibiotics and 15 natural polyp...

journal_title：Planta medica

authors： Lin RD,Chin YP,Hou WC,Lee MH

更新日期：2008-06-01 00:00:00

abstract：:Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs. Quasipanaxatriol, 20(S)-proto...

journal_title：Planta medica

authors： Hasegawa H,Sung JH,Matsumiya S,Uchiyama M,Inouye Y,Kasai R,Yamasaki K

更新日期：1995-10-01 00:00:00

abstract：:Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3- 7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3- O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic acti...

journal_title：Planta medica

authors： Liu H,Chou GX,Wang JM,Ji LL,Wang ZT

更新日期：2011-05-01 00:00:00

abstract：:Rhizomes of Actaea racemosa L. (formerly Cimicifuga racemosa) gained increasing interest as a plant-derived drug due to its hormone-like activity and the absence of estrogenic activity. According to the Current Good Manufacturing Practices guidelines and pharmacopeial standards, quality assessment of herbal starting m...

journal_title：Planta medica

authors： Bittner M,Krähmer A,Schenk R,Springer A,Gudi G,Melzig MF

更新日期：2017-08-01 00:00:00