Abstract:
:Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3- 7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3- O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against human hepatocellular carcinoma cells, with IC₅₀ values of 3.89 µM and 7.47 µM on SMMC7721, and 10.87 µM and 19.10 µM on Bel-7402 cell lines, respectively.
journal_name
Planta Medjournal_title
Planta medicaauthors
Liu H,Chou GX,Wang JM,Ji LL,Wang ZTdoi
10.1055/s-0030-1250633subject
Has Abstractpub_date
2011-05-01 00:00:00pages
845-8issue
8eissn
0032-0943issn
1439-0221journal_volume
77pub_type
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