Abstract:
:Flavonoids, important components of human diet, have been claimed to possess a significant antiplatelet potential, in particular due to their effects on the arachidonic acid cascade. Due to variable and incomplete results, this study was aimed at delivering a detailed analysis of the effects of 29 structurally relevant, mainly natural flavonoids on three consecutive steps of the arachidonic acid cascade.Only the isoflavonoids genistein and daidzein were shown to possess a marked cyclooxygenase-1 inhibitory activity, which was higher than that of acetylsalicylic acid using the isolated ovine enzyme, and physiologically relevant, although lower than acetylsalicylic acid in human platelets. None of the tested flavonoids possesses an effect on thromboxane synthase in a clinically achievable concentration. Contrarily, many flavonoids, particularly those possessing an isolated 7-hydroxyl group and/or a 4'-hydroxyl group, acted as antagonists on thromboxane receptors. Interestingly, the substitution of the free 7-hydroxyl group by glucose might not abolish the activity.In conclusion, the consumption of few flavonoids in a diet, particularly of the isoflavonoids genistein and daidzein, may positively influence platelet aggregation.
journal_name
Planta Medjournal_title
Planta medicaauthors
Karlíčková J,Říha M,Filipský T,Macáková K,Hrdina R,Mladěnka Pdoi
10.1055/s-0035-1557902subject
Has Abstractpub_date
2016-01-01 00:00:00pages
76-83issue
1-2eissn
0032-0943issn
1439-0221journal_volume
82pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::Two new phenolic glycosides characterized as idesin salicylate (1) and 2-hydroxyphenol-1-O-beta-D-glucopyranosyl-(6-->1)- alpha-L-rhamnopyranoside (2) were isolated with four known compounds, idescarpin (3), idesin (4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester (5) and salirepin (6), from the fruits of...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-951771
更新日期:2007-02-01 00:00:00
abstract::The in vitro antiprotozoal activity of 18 natural flavonoids has been determined against Entamoeba histolytica and Giardia lamblia. (-)-Epicatechin, (-)-epigallocatechin and kaempferol were the most active flavonoids against both protozoa. ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960445
更新日期:1999-02-01 00:00:00
abstract::Cordatolide A and B were re-isolated from Calophyllum cordato-oblongum, an endemic species of Sri Lanka, and found to inhibit HIV-1 reverse transcriptase with IC50 values of 12.3 and 19.0 microM, respectively. ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-957483
更新日期:1998-06-01 00:00:00
abstract::YANG XIN is a traditional Chinese medicine formulation used for nervous fatigue and consists of a proprietary blend of concentrated extracts from 18 plant ingredients. The 18 constituent plant ingredients, YANG XIN capsules, and formulations 2014-005_1 A and 1B were extracted by consecutive 24-hour macerations with di...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106170
更新日期:2016-08-01 00:00:00
abstract::The hydroalcoholic extract (HE) obtained from stems and leaves of Hedyosmum brasiliense, given i.p., produced significant inhibition of acetic acid-induced abdominal constriction in mice, with a mean ID50 of 12.7 mg/kg. This effect installed rapidly (0.5 h) and lasted for up to 2 h. Given orally up to 1000 mg/kg, the ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-14007
更新日期:1999-08-01 00:00:00
abstract::Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-981595
更新日期:2007-09-01 00:00:00
abstract::A simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of Curcuma longa has been developed. The method is of general applicability for the separation of compounds containing acidic and chelating groups a...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8533
更新日期:2000-05-01 00:00:00
abstract::The chloroform extract of Valeriana officinalis led to the isolation of clionasterol-3-O-beta-D-glucopyranoside and a mixture of 6'-O-acyl-beta-D-glucosyl-clionasterols. The acyl moieties were identified as hexadecanoyl, 8 E,11 E-octadecadienoyl and 14-methylpentadecanoyl by alkaline hydrolysis followed by GC-MS analy...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-864179
更新日期:2005-10-01 00:00:00
abstract::The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1)...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8634
更新日期:2000-10-01 00:00:00
abstract::Seven flavonol 3- O-glycosides were isolated from the flowers of CALENDULA OFFICINALIS L. Their structures were elucidated as isorhamnetin 3- O-glucoside, rutinoside, neohesperidoside, 2 (G)-rhamnosylrutinoside, quercetin glucoside, neohesperidoside, and 2 (G)-rhamnosylrutinoside by paper and thin layer chromatography...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961831
更新日期:1989-02-01 00:00:00
abstract::Three new sauchinone analogues, sauchinones B-D (1-3), together with sauchinone (4), were isolated from the aerial part of Saururus chinensis. Structures of the new compounds were determined by extensive spectroscopic data as well as X-ray analysis. Compounds 3 and 4 inhibited nitric oxide production in lipopolysaccha...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1351053
更新日期:2013-12-01 00:00:00
abstract::The ethanolic extract of Ilex aquifolium L. (Aquifoliaceae) concentration-dependently inhibited leukotriene B4 biosynthesis in isolated bovine PMNL with an IC50 value of about 60 micrograms/ml, whereas the effect on epidermal 12(S)-HETE biosynthesis was much less pronounced. The extract also inhibited the non-enzymati...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957509
更新日期:1998-08-01 00:00:00
abstract::Two new depsides as well as the known p-hydroxybenzoic acid and its methyl ester, protocatechuic acid, 2-(4-hydroxyphenyl)-ethanol, 2-(3,4-dihydroxyphenyl)-ethanol and the flavonoids kaempferol, quercetin, luteolin and hypolaetin and the glycosides 3- O-beta- D-glucopyranosylquercetin (isoquercitrine), 3- O-beta- D-gl...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-818956
更新日期:2004-04-01 00:00:00
abstract::Paeoniae Radix (the roots of Paeonia lactiflora Pallas) is a crude drug that is used in Asia and Europe to improve blood flow. We studied its vasodilator effect and mechanisms of action in vitro. The extract from Paeoniae Radix (PRE) relaxed prostaglandin F2a-precontracted aortic ring preparations of isolated rat aort...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957934
更新日期:1996-10-01 00:00:00
abstract::Three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 β,8 β-dihydroxy-guaia-10(14)-en-1 α,4 α,5 α,6 β,7 α,11 βH-...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250369
更新日期:2011-03-01 00:00:00
abstract::A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0626-7356
更新日期:2018-11-01 00:00:00
abstract::Hydroalcoholic extracts and pressed juice from Echinacea pallida were phytochemically characterised by HPLC-MS analyses. Ferulic and caffeic acid derivatives were identified as major constituents. All tested extracts and pressed juice from Echinacea pallida exhibited a low cytotoxic activity on monkey kidney cells in ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1186137
更新日期:2010-02-01 00:00:00
abstract::The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957611
更新日期:1997-02-01 00:00:00
abstract::Phytochemical investigation of the ethyl acetate extract from the aerial parts of Eryngium triquetrum Vahl resulted in the isolation of new polyacetylenes, triquetridiol (6) and trans-epoxy-triquetrol (7a/7b, diastereomeric mixture), and the lignan demethoxy carolignan Z (8a/8b, erythro/threo pair), together with a se...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-110316
更新日期:2016-11-01 00:00:00
abstract::The ripe berries of Harrisonia abyssinica yielded two new prenylated acetophenones, namely 5-(ethan-1'''-one)-4,6-dihydroxy-7-(3'',3''-dimethylallyl)-2 S-(1' S-hydroxy-1',5'-dimethylhex-4'-enyl)-2,3-dihydrobenzofuran (1) and 5-(2'''-hydroxyethan-1'''-one)-4,6-dihydroxy-7-(3'',3''-dimethylallyl)-2 S-(1' S-hydroxy-1',5'...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0031-1298143
更新日期:2012-03-01 00:00:00
abstract::A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tum...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2002-23138
更新日期:2002-03-01 00:00:00
abstract::Effects of puerarin, an active principle contained in the roots of Pueraria lobata (Leguminosae), on the regulation of glucose metabolism in an insulin deficient state were investigated in cultured myoblast C 2 C 12 cells using glucose uptake as indicator. Puerarin enhanced the uptake of radioactive glucose into C 2 C...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2002-35656
更新日期:2002-11-01 00:00:00
abstract::Ocimum basilicum L. is an aromatic herb used in Brazil to treat illnesses such as respiratory and rheumatic problems, vomiting, and pain. In the present study, the chemical composition, acute toxicity, and antinociceptive effects of the essential oil (EO) of the cultivar "Maria Bonita" obtained from O. basilicum L. PI...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250607
更新日期:2011-05-01 00:00:00
abstract::Activity-guided fractionation of the dichloromethane extract from leaves of Piper fulvescens, using an agar overlay bioautographic method, led to the isolation of three antifungal neolignans identified as conocarpan, eupomatenoid 5 and eupomatenoid 6. The minimal inhibitory concentration of these three neolignans agai...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2001-18838
更新日期:2001-12-01 00:00:00
abstract::From the essential oil of Commiphora guidotti seven sesquiterpene hydrocarbons and a furanosesquiterpenoid, furanodiene, were isolated. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969896
更新日期:1983-06-01 00:00:00
abstract::Strictosidine synthase was partially purified from Catharanthus roseus cell suspension cultures and immobilized on CNBr-activated Sepharose. The immobilized enzyme exhibits a thermostability increased 300 fold over that of the soluble enzyme and catalyses exclusively the formation of the 3alpha(S)-isomer, strictosidin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-970008
更新日期:1982-09-01 00:00:00
abstract::Juniperus (Cupressaceae, Pinales) plants are widely distributed in the Qinghai-Tibet Plateau of China. The leaves and twigs of at least 8 Juniperus species (J. pingii, J. pingii var. wilsonii, J. squamata, J. recurva var. coxii, J. saltuaria, J. indica, J. tibetica and J. convallium var. microsperma) have been used as...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1194-0471
更新日期:2020-11-01 00:00:00
abstract::Two new acylated secoiridoid glycosides were isolated from the aqueous acetone extract of the whole herb of Gentiana algida. The structures of these new products were established by spectral and chemical methods as 6'-(2,3-dihydroxybenzoyl)sweroside and 6'-(2,3-dihydroxybenzoyl)swertiamarin, respectively. ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-957770
更新日期:1997-12-01 00:00:00
abstract::There is an obvious discrepancy between the popularity of mistletoe extracts and their classification as a non-conventional treatment modality with unproven efficacy in oncology. The commercial preparations suffer from several major drawbacks: lack of precise declarations for the molecular characteristics and the conc...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2006-959396
更新日期:1994-02-01 00:00:00
abstract::Seven phenolic derivatives, 2,4-bis(4-hydroxybenzyl)phenol ( 1), bis[4(beta- D-glucopyranosyloxy)-benzyl] ( S)-(-)-2-isopropylmalate ( 2), bis[4-(beta- D-gluco-pyranosyloxy)benzyl] ( S)-(-)-2-sec-butylmalate ( 3), 4-hydroxybenzyaldehyde ( 4), 4,4'-dihydroxydiphenyl-methane ( 5), 4-hydroxybenzyl alcohol ( 6), and 4-(be...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959702
更新日期:1993-08-01 00:00:00