Abstract:
:The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). A cell-to-cell adhesion assay showed that 3,5-dihydroxy-4'-methoxystilbene and 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucopyranoside as well as resveratrol blocked significantly TNF-alpha-inducing cell-cell adhesion between human umbilical vein endothelial cells (HUVEC) and THP-1 cells.
journal_name
Planta Medjournal_title
Planta medicaauthors
Ahn KS,Kim JH,Oh SR,Ryu SY,Lee HKdoi
10.1055/s-2000-8634subject
Has Abstractpub_date
2000-10-01 00:00:00pages
641-4issue
7eissn
0032-0943issn
1439-0221journal_volume
66pub_type
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