Abstract:
:Cissampentine A (1), an enantiomer of cissampentin, three new cycleatjehenine-type bisbenzylisoquinoline alkaloids, cissampentine B-D (2-4), and five known alkaloids were isolated from the roots of Cyclea tonkinensis. Their structures were established by interpretation of NMR, high-resolution ESI-MS data, and CD spectra. In vitro studies indicated that compounds 1 and 4 exhibited cytotoxicity against the HCT-8 tumor cell line (IC50 values of 8.97 and 9.73 µM, respectively), and compound 4 was also active against the Bel-7402 tumor cell line (IC50 value of 5.36 µM).
journal_name
Planta Medjournal_title
Planta medicaauthors
Wang JZ,Liao J,Xu WL,Chen XBdoi
10.1055/s-0035-1545882subject
Has Abstractpub_date
2015-05-01 00:00:00pages
600-5issue
7eissn
0032-0943issn
1439-0221journal_volume
81pub_type
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