Stimulation of Indole Alkaloid Production in Cell Suspension Cultures of Catharanthus roseus by Abscisic Acid.

Abstract:

:When added to suspension cultures of CATHARANTHUS ROSEUS, abscisic acid (ABA) stimulated intracellular accumulation of the indole alkaloids catharanthine and ajmalicine in both flask and 30 litre fermenter-scale systems. The response varied, and depended upon the cell line, the concentration and source of the ABA, and the growth phase at which the cells were treated. Precise timing of ABA addition to cells in a 301 fermenter resulted in a catharanthine yield of 85.25 mg/l after 10 days of cultivation. We propose that ABA may be useful for increasing the yield and reducing the production time for commercially useful secondary plant metabolites.

journal_name

Planta Med

journal_title

Planta medica

authors

Smith JI,Smart NJ,Kurz WG,Misawa M

doi

10.1055/s-2006-962775

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

470-4

issue

5

eissn

0032-0943

issn

1439-0221

journal_volume

53

pub_type

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