Abstract:
:Hot water extract (ALR-0) of rhizomes of Atractylodes lanceo DC. was fractionated into MeOH-soluble fraction (ALR-1), supernatant fraction of EtOH precipitation (ALR-3 + 4), and crude polysaccharide fraction (ALR-5). Among these fractions, only ALR-5 showed potent stimulating activity for proliferation of bone marrow cells mediated by Peyer's patch cells. ALR-5 gave three potently active carbohydrate-rich fractions (ALR-5IIa, 5IIb, and 5IIc) by anion-exchange chromatography on DEAE-Sepharose CL-6B, and three active polysaccharides (ALR-5IIa-1-1, ALR-5IIb-2-2, and ALR-5IIc-3-1) were further purified from the respective fractions. The order of activity was revealed to be ALR-5IIb-2-2 > or = ALR-5IIa-1-1 > ALR-5IIc-3-1, ALR-5IIa-1-1, 5IIb-2-2, and 5IIc-3-1 each was eluted as a single peak on HPLC and their molecular weights were estimated to be 74,000, 3,100, 16,000, respectively. ALR-5IIa-1-1 consisted mainly of Ara and Gal (molar ratio; 0.6: 1.0) in addition to a trace amount of uronic acid whereas ALR-5IIb-2-2 and ALR-5IIc-3-1 mainly comprised Ara, Gal, GlcA, and GalA (molar ratio; 0.2: 1.0: 0.2: 0.8, and 0.5: 1.0: 0.7: 1.5, respectively). Methylation analysis indicated that ALR-5IIa-1-1 consisted mainly of terminal Araf, 4- or 5-linked Ara, 3.4- or 3.5-branched Ara, and 3-linked, 4-linked, and 3,6-branched Gal. ALR-5IIb-2-2 and ALR-5IIc-3-1 were composed mainly of terminal Araf, 4- or 5-linked Ara, 4-linked Gal, 4-linked GalA, and terminal GlcA. In addition, ALR-5IIb-2-2 mainly comprised 4-linked Xyl whereas ALR-5IIc-3-1 consisted mainly of 2,4-branched Rha. Single radial gel diffusion indicated that ALR-5IIa-1-1 showed a strong reactivity with beta-glucosyl-Yariv antigen, whereas ALR-5IIb-2-2 and ALR-5IIc-3-1 did not show the reactivity with the antigen. Treatments of ALR-5IIa with NalO4, NaClO2 and pronase did not reduce the stimulating activity for Peyer's patch cells, however combination of exo-alpha-L-arabinofuranosidase and exo-beta-D-(1-->3)-galactanase digestions of ALR-5IIa-1-1 significantly decreased its activity.
journal_name
Planta Medjournal_title
Planta medicaauthors
Yu KW,Kiyohara H,Matsumoto T,Yang HC,Yamada Hdoi
10.1055/s-2006-957564subject
Has Abstractpub_date
1998-12-01 00:00:00pages
714-9issue
8eissn
0032-0943issn
1439-0221journal_volume
64pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance for the Pacific Islanders. Kava is also sold as a herbal supplement or recreational beverage consumed for its mild inebriating effect in Europe and North America. With a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0637-2400
更新日期:2018-11-01 00:00:00
abstract::Andrographolide (Andro) is a potentially anti-inflammatory diterpenoid lactone isolated from the traditional herbal medicine ANDROGRAPHIS PANICULATA, which has been effectively used for the treatment of infection, inflammation, cold, fever and diarrhea in China for centuries. In the current study, we found that Andro ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-990230
更新日期:2007-10-01 00:00:00
abstract::Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106168
更新日期:2016-06-01 00:00:00
abstract::From the essential oil of Commiphora guidotti seven sesquiterpene hydrocarbons and a furanosesquiterpenoid, furanodiene, were isolated. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969896
更新日期:1983-06-01 00:00:00
abstract::Embelia ribes Burm. f. (Myrsinaceae) is one of the important plants used in Indian traditional medicine. RAPD-PCR analysis was performed to obtain species-specific DNA fragments. A band of 906 bp that was specific to Embelia ribes irrespective of the geographical source was obtained using the random decamer primer OPF...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1034279
更新日期:2008-02-01 00:00:00
abstract::An efficient in vitro propagation protocol for rapidly producing Cannabis sativa plantlets from young leaf tissue was developed. Using gas chromatography-flame ionization detection (GC-FID), high THC yielding elite female clone of a drug-type CANNABIS variety (MX) was screened and its vegetatively propagated clones we...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1249773
更新日期:2010-10-01 00:00:00
abstract::Tryptanthrin and (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-inflammatory and antiallergic alkaloids, and shown to inhibit COX-2, 5-LOX catalyzed leukotriene synthesis, and mast cell degranulation at low µM to nM concentrations. To ass...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-110323
更新日期:2016-08-01 00:00:00
abstract::Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, su...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1368300
更新日期:2014-04-01 00:00:00
abstract::Six dietary isothiocyanates, allyl-isothiocyanate, benzyl-isothiocyanate, phenylethyl-isothiocyanate, sulforaphane, erucin, and iberin, were tested for their trypanocidal activities in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. All isothiocyanates showed a dose-dependent effect on the growth ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1360262
更新日期:2014-02-01 00:00:00
abstract::At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101247
更新日期:2016-03-01 00:00:00
abstract::The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed. Xanthoxyline (30 to 300 microM) inhibited contractions of t...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960878
更新日期:1990-02-01 00:00:00
abstract::The endophytic microbiome in medicinal plants is rich and diverse, but few studies have followed the endophytic microbiome of medicinal plants in different tissues with their growth. In this study, we examined the endophytic bacterial and fungal community structures associated with both the stem and root compartments ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1046-1022
更新日期:2020-09-01 00:00:00
abstract::Five new xanthone glycosides, comastomasides A-E (1-5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1-5 were evaluated for their hepatoprotective activity and cytotoxicity ag...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315079
更新日期:2012-09-01 00:00:00
abstract::Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improve...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-111012
更新日期:2017-11-01 00:00:00
abstract::Annona purpurea has been traditionally used by indigenous and socioeconomically disadvantaged people to treat infectious and parasitic diseases, including amoebiasis. The goal of this study was to assess the effect of a crude methanolic extract, an alkaloid extract, and aporphine alkaloids from leaves of A. purpurea o...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1111-9566
更新日期:2020-04-01 00:00:00
abstract::Two new acylated secoiridoid glycosides were isolated from the aqueous acetone extract of the whole herb of Gentiana algida. The structures of these new products were established by spectral and chemical methods as 6'-(2,3-dihydroxybenzoyl)sweroside and 6'-(2,3-dihydroxybenzoyl)swertiamarin, respectively. ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-957770
更新日期:1997-12-01 00:00:00
abstract::HPLC determinations of the aescin contents in calli and embryoids from leaf explants of AESCULUS HIPPOCASTANUM L. were carried out in order to determine whether it was possible to obtain aescin-forming proliferations IN VITRO. The results indicate that embryogenic calli and embryoids derived from them produce an amoun...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960016
更新日期:1991-02-01 00:00:00
abstract::The major alkaloids of PAPAVER TRINIIFOLIUM collected in two different parts of Anatolia have proved to be of the aporphine, morphinane and rhoeadine types. The two collections possessed different major alkaloids and the existence of chemical strains is indicated. In addition to the aporphine-(floripavidine), the morp...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969808
更新日期:1983-09-01 00:00:00
abstract::The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-42794
更新日期:2003-08-01 00:00:00
abstract::Protopanaxatriol and protopanaxadiol exhibit limited oral bioavailability due to the poor solubility and intestinal cytochromes P450-mediated metabolism. This study set out to develop a novel cytochromes P450 inhibitory excipient(s)-based self-microemulsion to encapsulate protopanaxatriol and protopanaxadiol so as to ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106726
更新日期:2017-03-01 00:00:00
abstract::The present study aimed to investigate standardized ethanol extracts of fruit and leaves of Piper sarmentosum for their in vivo antioxidant activity in rats using a CCl (4)-induced oxidative stress model. The standardization was based on the quantification of the markers pellitorine, sarmentine and sarmentosine by hig...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1186279
更新日期:2010-03-01 00:00:00
abstract::Use of herbal dietary supplements by the public is common and has been happening for centuries. In the United States, the Food and Drug Administration has a limited scope of regulation over marketed herbal dietary supplements, which may contain toxic botanical compounds that pose a public health risk. While the Food a...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/a-0605-3786
更新日期:2018-07-01 00:00:00
abstract::A novel bibenzyl, a new bibenzyl, two new phenanthrenes, and a new lignin glycoside, namely longicornuol A (1), 4-[2-(3-hdroxyphenol)-1-methoxyethyl]-2,6-dimethoxyphenol (2), 5-hydroxy-7-methoxy-9,10-dihydrophenanthrene-1,4-dione (3), 7-methoxy-9,10-dihydrophenanthrene-2,4,5-triol (4) and erythro-1-(4-O-beta-D-glucopy...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1074492
更新日期:2008-04-01 00:00:00
abstract::The isoflavonoids found in soy have attracted great interest as dietary phytoestrogens that might be effective for postmenopausal hormone replacement therapy. Special attention has been devoted to the hormonal effects of various isoflavonoids, like genistein (GEN) and daidzein's (DAID) potent metabolite, equol (EQ). H...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1186136
更新日期:2010-02-01 00:00:00
abstract::The effect of a lignan-enriched extract of the fruits of Schisandra chinensis (FS) on hepatic glutathione (GSH) status was examined in both control and carbon tetrachloride (CCl4)-treated rats. FS treatment caused a dose-dependent enhancement in hepatic GSH status, as evidenced by significant increases in hepatic GSH ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-958032
更新日期:1995-04-01 00:00:00
abstract::As an exploratory investigation of antimicrobial promoting compounds, 3- O-acyl-(-)-epicatechins and 3- O-acyl-(+)-catechins possessing various aromatic groups and aliphatic chains of varying length from C4 to C16 for increasing lipophilicity were synthesized and tested for antimicrobial activities against Gram-positi...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2004-818923
更新日期:2004-03-01 00:00:00
abstract::VERATRUM CALIFORNICUM (Liliaceae) is an important monocotyledonous medicinal plant which is the only source of the anticancer compound cyclopamine. An IN VITRO culture system for somatic embryogenesis and green plant regeneration of VERATRUM CALIFORNICUM was developed. Embryogenic calli were induced from mature embryo...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-946697
更新日期:2006-10-01 00:00:00
abstract::Tissue callus cultures originating from CHELIDONIUM MAJUS L. seeds were established on Gamborg B5, Murashige-Skoog (MS), and Schenk-Hildebrandt (SH) media. In all experimental conditions, calli accumulated a complex pattern of isoquinoline derivatives. The highest values, both in growth and in sanguinarine production,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960141
更新日期:1991-10-01 00:00:00
abstract::The nature of gene action for biomass yield and tropane alkaloid content was ascertained through diallel analysis in Egyptian henbane, HYOSCYAMUS MUTICUS L. Dominance variation was preponderant over additive genetic variance, dominance being in the overdominance range for both traits. On an overall basis, recessive al...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961395
更新日期:1992-02-01 00:00:00
abstract::In this study we investigated the effects of concomitant food intake on the bioavailability of distinct boswellic acids (BAs) from the test preparation BSE-018, a dry extract from Boswellia serrata gum resin. In a randomised, open, single-dose, two-way crossover study, healthy male subjects received three capsules of ...
journal_title:Planta medica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2004-835844
更新日期:2004-12-01 00:00:00