Abstract:
:We have previously reported that saiboku-to, an Oriental herbal remedy composed of a mixture of 10 different herbal extracts, possesses anti-histamine release effect on mast cells in rats. This effect may be due mainly to the extract of the bark of Magnolia obovata (M. obovata), a constituent herb of saiboku-to. In the present study, it was demonstrated that the bark extract inhibited compound 48/80 (C48/80)-induced histamine release from mast cells in a concentration-dependent manner (50 % inhibitory concentration, IC(50) = 56.98 microg/ml). Furthermore, the inhibitory activity was found in the methanol fraction, but not in water and 50 % aqueous methanol fractions derived from the bark extract. Magnolol and honokiol isolated from the methanol fraction inhibited C48/80-induced histamine release from mast cells. The potency of magnolol (IC(50) = 1.04 microg/ml) was greater than that of honokiol (IC(50) = 2.77 microg/ml). Furthermore, the actual amount of magnolol (49.76 +/- 1.14 mg) contained in the bark of M. obovata (5 g) was greater than that (8.58 +/- 0.19 mg) of honokiol. Taken together, the present results suggest that magnolol may be responsible for the biological efficacy of the bark extract of M. obovata.
journal_name
Planta Medjournal_title
Planta medicaauthors
Ikarashi Y,Yuzurihara M,Sakakibara I,Nakai Y,Hattori N,Maruyama Ydoi
10.1055/s-2001-18354subject
Has Abstractpub_date
2001-11-01 00:00:00pages
709-13issue
8eissn
0032-0943issn
1439-0221journal_volume
67pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::The dietary intake of flavonoids seems to be inversely related to cardiovascular mortality. The consumption of isoflavonoids is increasing in the general population, especially due to the use of food supplements and a variety of isoflavonoid-rich foods. However, detailed studies on the vascular influence of individual...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1158-9422
更新日期:2020-07-01 00:00:00
abstract::The composition and the antimicrobial activity of the essential oil from the leaves of Peumus boldus is investigated. Analyses of the oil obtained by hydrodistillation were carried out by GC and GC-MS using columns of two different stationary phases. Fractionation of the essential oil by column chromatography on silic...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960461
更新日期:1999-03-01 00:00:00
abstract::In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2) and the subsequent...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969527
更新日期:1985-10-01 00:00:00
abstract::Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280266
更新日期:2012-01-01 00:00:00
abstract::A simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of Curcuma longa has been developed. The method is of general applicability for the separation of compounds containing acidic and chelating groups a...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8533
更新日期:2000-05-01 00:00:00
abstract::Acute kidney injury is a common and severe complication of acute myocardial infarction and cardiac surgery. It results in increased mortality, morbidity, and duration of hospitalization. Baicalein is a component of the root of Scutellaria baicalensis, which has traditionally been used to treat cardiovascular and liver...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558114
更新日期:2016-02-01 00:00:00
abstract::Many herbs, and recently their biomass from in vitro cultures, are essential for the treatment of diseases. The aim of this study was to determine the optimal growth of Bacopa monnieri (water hyssop) in an in vitro culture and to examine if extracts of the B. monnieri biomass from the in vitro culture would affect hyd...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558166
更新日期:2016-02-01 00:00:00
abstract::This perspective describes some commonly used animal models for the evaluation of potential chemopreventive agents in colon carcinogenesis. Special emphasis is given to the azoxymethane (AOM)/1,2-dimethylhydrazine (DMH) rat model and APCMIN mice, carrying a mutation in APC, a key gene in human carcinogenesis. In the A...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1074577
更新日期:2008-10-01 00:00:00
abstract::A new indole alkaloid, galanthindole, was isolated from Galanthus plicatus ssp. byzantinus (Amaryllidaceae), a plant native to northwestern Turkey. Incorporating a non-fused indole ring, galanthindole may represent the prototype of a new subgroup of the Amaryllidaceae alkaloids. Two other bases, (+)-11-hydroxyvittatin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-43206
更新日期:2003-09-01 00:00:00
abstract::Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-958094
更新日期:1995-08-01 00:00:00
abstract::Natural products research is increasingly turning to marine animals, plants, and microbes as source organisms. Several marine natural products are currently in preclinical and clinical evaluation, others show promising biological activities in in vitro and in vivo assays. Investigations of biological and chemical ecol...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2006-957861
更新日期:1996-06-01 00:00:00
abstract::Andrographis paniculata contains four major active diterpenoids, including andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4), which exhibit differences in types and/or degrees of their pharmacological activity. Previous pharmacokinetic studies in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558115
更新日期:2016-01-01 00:00:00
abstract::In our previous study, we reported the interesting in vitro antiplasmodial activity of some Rwandan plant extracts. This gave rise to the need for these extracts to also be evaluated in vivo and to identify the compounds responsible for their antiplasmodial activity. The aim of our study was, on the one hand, to evalu...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1368322
更新日期:2014-04-01 00:00:00
abstract::Products of lipoxygenase metabolism play a role in the pathogenesis of psoriasis. Four protoberberine alkaloids, berberine, oxyberberine, jatrorrhizine, columbamine, and two aporphine alkaloids, magnoflorine, and corytuberine, isolated from Mahonia aquifolium, were tested for lipoxygenase inhibition. Oxyberberine, cor...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-958107
更新日期:1995-08-01 00:00:00
abstract::Activator protein 1 (AP-1) is a transcription factor which plays a critical role in inflammation and carcinogenesis. The present study was conducted to investigate the effect of berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, on the activity of AP-1 using a reporter gene assay ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960795
更新日期:1999-05-01 00:00:00
abstract::Agnus Castus Fruit is defined in the European Pharmacopoeia as the dried ripe fruit of Vitex agnus-castus. In Europe it is used as a medicine targeting premenstrual syndrome and climacteric disorder. In Japan, Agnus Castus Fruit is becoming popular as a raw material for over-the-counter drugs and health food products,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558089
更新日期:2016-01-01 00:00:00
abstract::A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibit...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280294
更新日期:2012-01-01 00:00:00
abstract::Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs. Quasipanaxatriol, 20(S)-proto...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-958126
更新日期:1995-10-01 00:00:00
abstract::The content of ursolic acid and oleanolic acid was determined in different plant parts of two Glechoma species, G. hederacea and G. hirsuta. To achieve optimal extraction conditions of ursolic acid and oleanolic acid from plant material, several methods including maceration, heat reflux, Soxhlet, and ultrasonic extrac...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1345-9377
更新日期:2021-01-15 00:00:00
abstract::ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-122344
更新日期:2017-05-01 00:00:00
abstract::Flavonoids, important components of human diet, have been claimed to possess a significant antiplatelet potential, in particular due to their effects on the arachidonic acid cascade. Due to variable and incomplete results, this study was aimed at delivering a detailed analysis of the effects of 29 structurally relevan...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1557902
更新日期:2016-01-01 00:00:00
abstract::Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. In addition to the poor survival rates, combinations using gemcitabine as a backbone have failed to show any benefit beyond monotherapy. These facts underscore an urgent need for novel therapeutic options and mot...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1249931
更新日期:2010-08-01 00:00:00
abstract::The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and ide...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-958139
更新日期:1995-10-01 00:00:00
abstract::This paper studies the effect of different concentrations of ethephon on the levels of the sesquiterpene, nootkatone, and of the flavanones, naringin and narirutin, in grapefruit fruits. The results show that nootkatone synthesis and/or accumulation was stimulated by all the concentrations of ethephon assayed, while t...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-958077
更新日期:1995-06-01 00:00:00
abstract::Endocrine activity can be demonstrated for components of the rhizome of CIMICIFUGA RACEMOSA using ovariectomized rats as experimental model. A selective reduction of the serum concentration of the pituitary luteinizing hormone (LH) takes place upon application of an extract. The active principle can be concentrated by...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969390
更新日期:1985-02-01 00:00:00
abstract::Northern Labrador tea, Rhododendron tomentosum ssp. subarcticum, is one of the most commonly used medicinal plants by Inuit and other First Nations peoples of Canada. The phenolic profile and seasonal variation of this commonly used medicinal plant remains largely unknown. To assess optimal harvesting time, R. tomento...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1270968
更新日期:2011-09-01 00:00:00
abstract::Interleukin (IL)-5 plays an important role in the progression of allergic inflammation. Here, we have isolated 21alpha-methylmelianodiol and 21beta-methylmelianodiol from Poncirus trifoliata (L.) Raf., a plant of the Rutaceae family, as the inhibitors of IL-5-dependent growth of Y16 pro-B cells by bioassay-guided frac...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1034329
更新日期:2008-03-01 00:00:00
abstract::Four new isoprenylated xanthones, cudraxanthones A, B and C were isolated from the N-hexane extract of the root bark of CUDRANIA TRICUSPIDATA (Carr.) Bur. (Japanese name "Hariguwa"; Moraceae), and cudraxanthone D from the benzene extract. The structures of cudraxanthones A, B, C and D were shown to be 1-4, respectivel...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969682
更新日期:1984-06-01 00:00:00
abstract::Praziquantel is the drug of choice for the treatment of schistosomiasis. However, several strains of Schistosoma mansoni are resistant to praziquantel, making it necessary to discover new drugs that might be used for its treatment. With this in mind, the properties of a schistosomicidal ethanolic extract of Garcinia b...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545927
更新日期:2015-06-01 00:00:00
abstract::Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetylshikonin (IC50...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959718
更新日期:1993-10-01 00:00:00