21-Methylmelianodiols from Poncirus trifoliata as inhibitors of interleukin-5 bioactivity in Pro-B cells.

abstract：:Compelling evidence suggests that infiltrating CD4+ type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain...

journal_title：Planta medica

authors： Chang SL,Chang CL,Chiang YM,Hsieh RH,Tzeng CR,Wu TK,Sytwu HK,Shyur LF,Yang WC

更新日期：2004-11-01 00:00:00

abstract：:Shoot-tips from several genotypes of the cardenolide-producing perennial shrub Digitalis obscura L. were successfully cryopreserved using the encapsulation-dehydration technique. Precultivation on MS medium containing 0.5 M sucrose, followed by 2.5 h dehydration (final weight 30 %) induced shoot regrowth in 42 % of cr...

journal_title：Planta medica

authors： Sales E,Nebauer SG,Arrillaga I,Segura J

更新日期：2001-12-01 00:00:00

abstract：:Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as ...

journal_title：Planta medica

authors： Yuan CM,Zhang Y,Tang GH,Li Y,He HP,Li SF,Hou L,Li XY,Di YT,Li SL,Hua HM,Hao XJ

更新日期：2013-01-01 00:00:00

abstract：:Orosunol and 8-demethylorosunol, two new 1-aryl-2,3-naphthalide lignans, have been isolated from Justicia flava root. Structures IV and V respectively have been proposed for them by spectral (UV, IR, PMR, (13)C NMR, and MS) and chemical evidence. ...

journal_title：Planta medica

authors： Olaniyi AA

更新日期：1982-03-01 00:00:00

abstract：:Bisbenzylisoquinoline alkaloids are known to affect immune responses as well as inflammatory responses, and have been used for the treatment of inflammatory symptoms in China. This study is aimed at elucidating the inhibitory effects of two alkaloids, fangchinoline and isotetrandrine, on the induction of the proinflam...

journal_title：Planta medica

authors： Onai N,Tsunokawa Y,Suda M,Watanabe N,Nakamura K,Sugimoto Y,Kobayashi Y

更新日期：1995-12-01 00:00:00

abstract：:Usnic acid, a lichen secondary metabolite produced by a whole number of lichens, has attracted the interest of researchers owing to its broad range of biological activity, including antiviral, antibiotic, anticancer properties, and it possessing a certain toxicity. The synthesis of new usnic acid derivatives and the i...

journal_title：Planta medica

authors： Dyrkheeva N,Luzina O,Filimonov A,Zakharova O,Ilina E,Zakharenko A,Kuprushkin M,Nilov D,Gushchina I,Švedas V,Salakhutdinov N,Lavrik O

更新日期：2019-01-01 00:00:00

abstract：:Four new benzofurans trans-5-(3-hydroxypropyl)-7-methoxy-2-[2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-hydroxyphenyl)-benzofuran-5-yl]benzofuran (1), (E)-5-(2-formylvinyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (2), 5-(3-butanoyloxypropyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (3), and 5...

journal_title：Planta medica

authors： Li QL,Li BG,Qi HY,Gao XP,Zhang GL

更新日期：2005-09-01 00:00:00

abstract：:Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatu...

journal_title：Planta medica

authors： Fürer K,Raith M,Brenneisen R,Mennet M,Simões-Wüst AP,von Mandach U,Hamburger M,Potterat O

更新日期：2013-11-01 00:00:00

abstract：:In natural product research, the isolation of biomarkers or bioactive compounds from complex natural extracts represents an essential step for de novo identification and bioactivity assessment. When pure natural products have to be obtained in milligram quantities, the chromatographic steps are generally labourious an...

journal_title：Planta medica

authors： Challal S,Queiroz EF,Debrus B,Kloeti W,Guillarme D,Gupta MP,Wolfender JL

更新日期：2015-11-01 00:00:00

abstract：:Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near ...

journal_title：Planta medica

authors： Lu YN,Cui P,Tian XQ,Lou LG,Fan CQ

更新日期：2016-06-01 00:00:00

abstract：:Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxi...

journal_title：Planta medica

authors： Huang X,Gao S,Fan L,Yu S,Liang X

更新日期：2004-05-01 00:00:00

abstract：:Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of beta-hexosaminidase from ...

journal_title：Planta medica

authors： Ryu SY,Kou NY,Choi HS,Ryu H,Kim TS,Kim KM

更新日期：2001-03-01 00:00:00

abstract：:It has been reported that cedarwood oil has sedative effects when inhaled. In this study, we evaluated sedative effects of inhaled cedrol, which is a major component of cedarwood oil. Accumulative spontaneous motor activity was significantly decreased in the cedrol-exposed Wistar rats. Similar results were confirmed i...

journal_title：Planta medica

authors： Kagawa D,Jokura H,Ochiai R,Tokimitsu I,Tsubone H

更新日期：2003-07-01 00:00:00

abstract：:VERATRUM CALIFORNICUM (Liliaceae) is an important monocotyledonous medicinal plant which is the only source of the anticancer compound cyclopamine. An IN VITRO culture system for somatic embryogenesis and green plant regeneration of VERATRUM CALIFORNICUM was developed. Embryogenic calli were induced from mature embryo...

journal_title：Planta medica

authors： Ma R,Ritala A,Oksman-Caldentey KM,Rischer H

更新日期：2006-10-01 00:00:00

abstract：:During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 microg/mL) whereas extracts from the inner barks of O.integerrima showed no antimalarial activity. Biflavanone (1), which had...

journal_title：Planta medica

authors： Ichino C,Kiyohara H,Soonthornchareonnon N,Chuakul W,Ishiyama A,Sekiguchi H,Namatame M,Otoguro K,Omura S,Yamada H

更新日期：2006-06-01 00:00:00

abstract：:The aggregation of the microtubule-associated protein tau is a significant event in many neurodegenerative diseases including Alzheimer's disease. The inhibition or reversal of tau aggregation is therefore a potential therapeutic strategy for these diseases. Fungal natural products have proven to be a rich source of u...

journal_title：Planta medica

authors： Paranjape SR,Chiang YM,Sanchez JF,Entwistle R,Wang CC,Oakley BR,Gamblin TC

更新日期：2014-01-01 00:00:00

abstract：:As an exploratory investigation of antimicrobial promoting compounds, 3- O-acyl-(-)-epicatechins and 3- O-acyl-(+)-catechins possessing various aromatic groups and aliphatic chains of varying length from C4 to C16 for increasing lipophilicity were synthesized and tested for antimicrobial activities against Gram-positi...

journal_title：Planta medica

authors： Park KD,Park YS,Cho SJ,Sun WS,Kim SH,Jung DH,Kim JH

更新日期：2004-03-01 00:00:00

abstract：:The content of ursolic acid and oleanolic acid was determined in different plant parts of two Glechoma species, G. hederacea and G. hirsuta. To achieve optimal extraction conditions of ursolic acid and oleanolic acid from plant material, several methods including maceration, heat reflux, Soxhlet, and ultrasonic extrac...

journal_title：Planta medica

authors： Grabowska K,Żmudzki P,Wróbel-Biedrawa D,Podolak I

更新日期：2021-01-15 00:00:00

abstract：:Seven new compounds, including four lignans, (+)-(8S,8′S)-9,9′-dibenzoylsecoisolariciresinol (1), (+)-(8S*,8′R*)-4,4′-dimethyloxomatairesinol (2), (+)-(7S*,8R*,8′R*,9′S*)-9′-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6),...

journal_title：Planta medica

authors： He WJ,Chu HB,Zhang YM,Han HJ,Yan H,Zeng GZ,Fu ZH,Olubanke O,Tan NH

更新日期：2011-11-01 00:00:00

abstract：:Five new xanthone glycosides, comastomasides A-E (1-5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1-5 were evaluated for their hepatoprotective activity and cytotoxicity ag...

journal_title：Planta medica

authors： Qiao Y,Yuan Y,Cui B,Zhang Y,Chen H,Li S,Li Y

更新日期：2012-09-01 00:00:00

abstract：:We have identified kamebakaurin as an inhibitor of NF-KB and elucidated its molecular mechanism as a specific inhibitor in the DNA-binding activity of the p50 subunit of NF-KB. Here, we describe its anti-inflammatory activity in in vitro and in vivo models. Kamebakaurin dose-dependently inhibited not only the expressi...

journal_title：Planta medica

authors： Lee JH,Choi JK,Noh MS,Hwang BY,Hong YS,Lee JJ

更新日期：2004-06-01 00:00:00

abstract：:We have previously reported that saiboku-to, an Oriental herbal remedy composed of a mixture of 10 different herbal extracts, possesses anti-histamine release effect on mast cells in rats. This effect may be due mainly to the extract of the bark of Magnolia obovata (M. obovata), a constituent herb of saiboku-to. In th...

journal_title：Planta medica

authors： Ikarashi Y,Yuzurihara M,Sakakibara I,Nakai Y,Hattori N,Maruyama Y

更新日期：2001-11-01 00:00:00

abstract：:This study demonstrated that plant extracts containing acetylenic isobutylamides and polyacetylenes, previously reported as occurring in Echinacea, have phototoxic antimicrobial activity against fungi, including clinically relevant pathogenic fungi. Results show that hexane extracts of Echinacea variably inhibit growt...

journal_title：Planta medica

authors： Binns SE,Purgina B,Bergeron C,Smith ML,Ball L,Baum BR,Arnason JT

更新日期：2000-04-01 00:00:00

abstract：:[6]-Gingerol potently inhibits peroxynitrite-induced oxidation and nitration reactions, but its mechanism of action is unclear. In order to discover the mechanism of inhibition, [6]-gingerol was reacted with peroxynitrite and the reaction mixture was analyzed using HPLC. The HPLC chromatogram showed one novel peak, in...

journal_title：Planta medica

authors： Ippoushi K,Ito H,Horie H,Azuma K

更新日期：2005-06-01 00:00:00

abstract：:Thyme extract is known to posses spasmolytic effects on isolated trachea and to increase ciliary activity. A small part of this effect is mediated via beta (2) receptors, but other receptors are supposed to be involved. Endothelin has a pathophysiological impact in asthma with respect to hyper-reagibility and contract...

journal_title：Planta medica

authors： Engelbertz J,Schwenk T,Kinzinger U,Schierstedt D,Verspohl EJ

更新日期：2008-10-01 00:00:00

abstract：:The roots of HAPLOPAPPUS FREEMONTII afforded in addition to the known 8-oxo-beta-cyperone two further derivatives. The structures were elucidated by highfield (1)H-NMR spectroscopy. ...

journal_title：Planta medica

authors： Jakupovic J,Boeker R,King RM

更新日期：1986-10-01 00:00:00

abstract：:Valeriana officinalis L. is a popular herbal treatment for mild sleep disorders. Clinical and non-clinical studies found contradictory results for valerian extracts and single constituents regarding the influence on sleep parameters. It was the aim of this study to investigate the sedative effects of a valerian root e...

journal_title：Planta medica

authors： Chow NK,Fretz M,Hamburger M,Butterweck V

更新日期：2011-05-01 00:00:00

abstract：:The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance of activated hepatic stellate cells (HSCs) by inducing apoptosis. Over the past several years, we have screened for natural products that mediate apoptosis in activated HSCs. Among the candidate compounds, honokiol, isolated...

journal_title：Planta medica

authors： Park EJ,Zhao YZ,Kim YH,Lee BH,Sohn DH

更新日期：2005-01-01 00:00:00

abstract：:Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of ...

journal_title：Planta medica

authors： Rojas A,Bah M,Rojas JI,Gutiérrez DM

更新日期：2000-12-01 00:00:00

abstract：:The preventive effects of hydroxychalcone derivatives on ulcer formation induced by severe necrotizing agents such as 60% ethanol in 150 mM HCl (HCl-ethanol) and 0.2 N NaOH in rats were examined. Among the compounds tested, 2',4'-dihydroxychalcone gave the strongest activity in both experimental models and protected t...

journal_title：Planta medica

authors： Yamamoto K,Kakegawa H,Ueda H,Matsumoto H,Sudo T,Miki T,Satoh T

更新日期：1992-10-01 00:00:00