21-Methylmelianodiols from Poncirus trifoliata as inhibitors of interleukin-5 bioactivity in Pro-B cells.


:Interleukin (IL)-5 plays an important role in the progression of allergic inflammation. Here, we have isolated 21alpha-methylmelianodiol and 21beta-methylmelianodiol from Poncirus trifoliata (L.) Raf., a plant of the Rutaceae family, as the inhibitors of IL-5-dependent growth of Y16 pro-B cells by bioassay-guided fractionation. 21alpha-Methylmelianodiol and 21beta-methylmelianodiol inhibited IL-5-dependent growth of Y16 cells in a dose-dependent manner with IC (50) values of 17 microM and 15 microM, respectively. A positive control, tyrphostin AG-490, exhibited an IC (50) value of 23 microM on IL-5 bioactivity. Further, we have documented that 21alpha-methylmelianodiol and 21beta-methylmelianodiol cause G1 arrest of IL-5-induced cell cycle progression of Y16 cells, and also reduce IL-5-dependent survival of the cells by apoptosis. This study could provide a pharmacological potential for P. trifoliata in treatment of IL-5-associated inflammatory disorders.


Planta Med


Planta medica


Lee IJ,Xu GH,Ju JH,Kim JA,Kwon SW,Lee SH,Han SB,Kim Y




Has Abstract


2008-03-01 00:00:00












  • Single-Lab Validation for Determination of Kavalactones and Flavokavains in Piper methysticum (Kava).

    abstract::Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance for the Pacific Islanders. Kava is also sold as a herbal supplement or recreational beverage consumed for its mild inebriating effect in Europe and North America. With a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Liu Y,Lund JA,Murch SJ,Brown PN

    更新日期:2018-11-01 00:00:00

  • Production of Sanguinarine by Chelidonium majus Callus Cultures.

    abstract::Tissue callus cultures originating from CHELIDONIUM MAJUS L. seeds were established on Gamborg B5, Murashige-Skoog (MS), and Schenk-Hildebrandt (SH) media. In all experimental conditions, calli accumulated a complex pattern of isoquinoline derivatives. The highest values, both in growth and in sanguinarine production,...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Colombo ML,Tomé F

    更新日期:1991-10-01 00:00:00

  • Induction of apoptosis by new ent-kaurene-type diterpenoids isolated from the New Zealand liverwort Jungermannia species.

    abstract::Some diterpenoids show various biological activities, including anti-inflammatory, anti-HIV and anti-tumor activity. Previously, we have focused our research on the apoptosis-inducing properties of diterpenoids and found that some ent-kaurene-type diterpenoids induced apoptosis in human leukemia HL-60 cells. In this s...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kondoh M,Nagashima F,Suzuki I,Harada M,Fujii M,Asakawa Y,Watanabe Y

    更新日期:2005-11-01 00:00:00

  • Antiherpetic activities of sulfated polysaccharides from green algae.

    abstract::In order to evaluate the potency of novel antiviral drugs, 11 natural sulfated polysaccharides (SPs) from 10 green algae ( Enteromorpha compressa, Monostroma nitidum, Caulerpa brachypus, C. okamurai, C. scapelliformis, Chaetomorpha crassa, C. spiralis, Codium adhaerens, C. fragille, and C. latum) and 4 synthetic sulfa...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee JB,Hayashi K,Maeda M,Hayashi T

    更新日期:2004-09-01 00:00:00

  • Gradient x Isocratic Elution CCC on the Isolation of Verbascoside and Other Phenylethanoids: Influence of the Complexity of the Matrix.

    abstract::Verbascoside is a phenylethanoid glycoside widely distributed in nature, especially among the order Lamiales, occurring in numerous plants that are constituents of folk medicine preparations. This natural compound, previously isolated by our group from the ethyl acetate extract of Lantana trifolia using the gradient a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Leitão GG,Pinto SC,de Oliveira DR,Timoteo P,Guimarães MG,Cordova WH,Leitão SG

    更新日期:2015-11-01 00:00:00

  • Studies on the antihyperlipidemic properties of Averrhoa bilimbi fruit in rats.

    abstract::Averrhoa bilimbi Linn. fruit and its extracts were screened for antihypercholesterolemic activity using Triton-induced hypercholesterolemia in rats as a model. The fruit and its water extract, but not alcohol and hexane extracts, showed remarkable antihypercholesterolemic activity. An active fraction, which showed act...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ambili S,Subramoniam A,Nagarajan NS

    更新日期:2009-01-01 00:00:00

  • Nano-Pelargonidin Protects Hyperglycemic-Induced L6 Cells against Mitochondrial Dysfunction.

    abstract::Nano-encapsulation of several natural products has become an important tool in enhancing the bioavailability of some modern drugs against many diseases. Pelargonidin is an anthocyanidin found in many fruits and vegetables. Pelargonidin is loaded with poly-lactide-co-glycolic-acid, a non-toxic biodegradable polymer, to...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Samadder A,Tarafdar D,Abraham SK,Ghosh K,Khuda-Bukhsh AR

    更新日期:2017-03-01 00:00:00

  • A Simple and Sensitive LC-MS/MS Method for Determination of Four Major Active Diterpenoids from Andrographis paniculata in Human Plasma and Its Application to a Pilot Study.

    abstract::Andrographis paniculata contains four major active diterpenoids, including andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4), which exhibit differences in types and/or degrees of their pharmacological activity. Previous pharmacokinetic studies in...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pholphana N,Panomvana D,Rangkadilok N,Suriyo T,Ungtrakul T,Pongpun W,Thaeopattha S,Satayavivad J

    更新日期:2016-01-01 00:00:00

  • Flavonoids from Litsea japonica Inhibit AGEs Formation and Rat Lense Aldose Reductase In Vitro and Vessel Dilation in Zebrafish.

    abstract::In our ongoing efforts to identify effective naturally sourced agents for the treating of diabetic complications, two new (1 and 2) and 11 known phenolic compounds (3-13) were isolated from an 80 % ethanol extract of Litsea japonica leaves. The structures of the new compounds were established by spectroscopic and chem...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee IS,Kim YJ,Jung SH,Kim JH,Kim JS

    更新日期:2017-02-01 00:00:00

  • Guaianolides from Lactuca saligna.

    abstract::The phytochemical investigation of the aerial parts of LACTUCA SALIGNA L. revealed the presence of lactucin, lactucopicrin, and a new guaianolide named 11beta,13-dihydrolactucopicrin. The structural configuration was established through spectral data. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Khalil AT,El-Fattah HA,Mansour ES

    更新日期:1991-04-01 00:00:00

  • Comparative antioxidant, prooxidant and cytotoxic activity of sigmoidin A and eriodictyol.

    abstract::Sigmoidin A (SGN) is a prenylated flavanone derivative of eriodictyol (ERD) with reported moderate antioxidant, antimicrobial and anti-inflammatory activity. Since ERD and other structurally similar antioxidant phenolic compounds have been shown to induce prooxidative macromolecular damage and cytotoxicity in cancer c...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Habtemariam S,Dagne E

    更新日期:2010-04-01 00:00:00

  • The effect of N-deacetylcolchiceine on serum lipoproteins in rats.

    abstract::N-Deacetylcolchiceine (DAC) administered i.p. to rats decreased the level of serum cholesterol and apoB. It was accompanied by the fall of HDL-C due to the decrease of both HDL subfractions HDLa and HDLb, and by a rather weaker decrease of LDL-C. The levels of serum and lipoprotein triacylglycerols were not significan...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Skottová N,Vecera R,Walterová D,Simánek V

    更新日期:1992-02-01 00:00:00

  • Anthraquinones of Cassia marginata seeds.

    abstract::From the defatted seeds of Cassia marginata fam (Caesalpinaceae) two new anthraquinone glycosides have been isolated and characterised as physcion-8-O-alpha-L-xylopyranoside and emodin-8-O-alpha-L-arabinopyranoside. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Duggal JK,Misra K

    更新日期:1982-05-01 00:00:00

  • Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling.

    abstract::Propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing proinflammatory cytokines. In order to demonstrate the anti-inflammatory effects and action mechanisms of magnolol and honokiol, several methods were employed....

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee J,Jung E,Park J,Jung K,Lee S,Hong S,Park J,Park E,Kim J,Park S,Park D

    更新日期:2005-04-01 00:00:00

  • Chirality influences the effects of linalool on physiological parameters of stress.

    abstract::The specific physiological responses induced by inhaling R-(-)- as well as S-(+)-linalool in 24 human subjects undergoing experimental stress were investigated in this study. Various physiological parameters of the autonomous nervous system (heart rate, blood pressure, electrodermal activity) as well as the endocrine ...

    journal_title:Planta medica

    pub_type: 杂志文章,随机对照试验


    authors: Höferl M,Krist S,Buchbauer G

    更新日期:2006-10-01 00:00:00

  • Immunoassays for the quantitative determination of colchicine.

    abstract::A radioimmunoassay as well as an enzyme immunoassay for the quantitation of fmol amounts of the alkaloid colchicine have been developed. The antiserum used for both assays was raised against a conjugate of colchicoside-bovine serum albumin. The crude serum was satisfactory for the performance of the radioimmunoassay. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Poulev A,Deus-Neumann B,Bombardelli E,Zenk MH

    更新日期:1994-02-01 00:00:00

  • Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages.

    abstract::Isovitexin exhibits potent antioxidant activities. In this study, the activity of nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages after incubation with isovitexin was investigated. Isovitexin was able to reduce the production of hydrogen peroxide induced by LPS in mouse macropha...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lin CM,Huang ST,Liang YC,Lin MS,Shih CM,Chang YC,Chen TY,Chen CT

    更新日期:2005-08-01 00:00:00

  • Arsenic trioxide-enhanced, matrine-induced apoptosis in multiple myeloma cell lines.

    abstract::Matrine and arsenic trioxide are monomers used in traditional Chinese medicine possessing anti-myeloma activities. In this study, we evaluated the effects and mechanisms of matrine, arsenic trioxide, and their combination therapy on the proliferation and apoptosis of the myeloma cell lines RPMI8226 and U266. The effec...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yu Q,Chen B,Zhang X,Qian W,Ye B,Zhou Y

    更新日期:2013-06-01 00:00:00

  • Tea triterpenoidal saponins from the roots of Camellia sinensis have inhibitory effects against alcohol dehydrogenase.

    abstract::Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1-10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NM...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Varughese T,Manir MM,Rahaman M,Kim JK,Lee BG,Moon SS

    更新日期:2011-12-01 00:00:00

  • alpha-Glucosidase inhibitors from Commelina communis.

    abstract::A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyrano...

    journal_title:Planta medica

    pub_type: 信件


    authors: Kim HS,Kim YH,Hong YS,Paek NS,Lee HS,Kim TH,Kim KW,Lee JJ

    更新日期:1999-06-01 00:00:00

  • [New cardioactive drugs II, detection and isolation of cardiotonic amines with ionpair-HPLC].

    abstract::An ionpair-HPLC-technic using a reversed-phase column was developed to screen plant extracts for cardiotonic amines and to isolate them in a preparative scale for direct MS and pharmacological investigations. By this method the positive inotropic tyramine could be isolated from Selenicereus grandiflorus (L.) Britt et ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wagner H,Grevel J

    更新日期:1982-01-01 00:00:00

  • Bioguided isolation of (9Z)-octadec-9-enoic acid from Phellodendron amurense Rupr. and identification of fatty acids as PTP1B inhibitors.

    abstract::The therapy of type-2 diabetes mellitus is one of the major challenges of our age. A possible strategy to prevent the progression of this disease is the inhibition of protein tyrosine phosphatase 1B (PTP1B), a major negative regulator in the insulin and leptin signalling pathway. Phellodendri amurensis cortex is a wel...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Steinmann D,Baumgartner RR,Heiss EH,Bartenstein S,Atanasov AG,Dirsch VM,Ganzera M,Stuppner H

    更新日期:2012-02-01 00:00:00

  • 11-deoxyalisol C and alisol D: new protostane-type triterpenoids from Alisma plantago-aquatica.

    abstract::New protostane-type triterpenes, 11-deoxyalisol C and alisol D, have been isolated from the rhizomes of ALISMA PLANTAGO-AQUATICA, and their structures have been elucidated on the basis of spectral and chemical data. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Fukuyama Y,Pei-Wu G,Rei W,Yamada T,Nakagawa K

    更新日期:1988-10-01 00:00:00

  • Rapid qualitative and quantitative determination of seven valuable taxanes from various Taxus species by UFLC-ESI-MS and UFLC-DAD.

    abstract::The distribution and level of yew constituents vary with species and tissues. In this study, a rapid and valid method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for simultaneous determination of paclitaxel and its six semisynthesis precursors in needles and hair roots ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ge GB,Liang SC,Hu Y,Liu XB,Mao YX,Zhang YY,Luan HW,Qiu MH,Yang L

    更新日期:2010-10-01 00:00:00

  • Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals.

    abstract::Antioxidants such as vitamin E may act differently on skin cells depending on the age of the skin and the level of oxidative damage induced. The effects of alpha-tocopherol (ATF) on H(2)O(2)-induced DNA damage and telomere shortening of normal human skin fibroblast cells derived from young and old individual donors we...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Makpol S,Zainuddin A,Rahim NA,Yusof YA,Ngah WZ

    更新日期:2010-06-01 00:00:00

  • Three pyrone glucosidic derivatives from Conyza albida.

    abstract::Three new pyrone glucosidic derivatives, together with the known pyromeconic acid glucoside, three acytelenes and two eudesmanes, were obtained from the aerial parts of Conyza albida. The structures were elucidated by high field NMR spectroscopy. ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Ahmed AA,Mohamed Ael-H,Tzakou O,Gani A,Yannitsaros A,El-Maghraby MA,Hassan ME,Zeller KP

    更新日期:2002-07-01 00:00:00

  • An in vitro Study on the Effect of Momordica charantia on Glucose Uptake and Glucose Metabolism in Rats.

    abstract::The effect of extracts of MOMORDICA CHARANTIA L. fruits on glucose metabolism and glucose uptake was investigated. The fruit of momordica, at all ripening stages, was found to contain two inhibitory compounds: one against hexokinase activity and the other against glucose uptake by rat intestinal fragments. Both inhibi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Meir P,Yaniv Z

    更新日期:1985-02-01 00:00:00

  • Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.

    abstract::Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable to capsaicin. The Chinese literature refers to Evodia fruits as a "hot nature" herb. In spite of the similarities in the actions of evodiamine and capsaicin in vitro, evodi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kobayashi Y,Nakano Y,Kizaki M,Hoshikuma K,Yokoo Y,Kamiya T

    更新日期:2001-10-01 00:00:00

  • A novel stilbene glucoside, oxyresveratrol 3'-O-beta-glucopyranoside, from the root bark of Morus alba.

    abstract::A novel stilbene glucoside was isolated from the root bark of Morus alba L. (Moraceae), along with mulberroside A, cis-mulberroside A, oxyresveratrol. The structure of the novel stilbene glucoside was determined as oxyresveratrol 3'-O-beta-glucopyranoside. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Qiu F,Komatsu K,Kawasaki K,Saito K,Yao X,Kano Y

    更新日期:1996-12-01 00:00:00

  • New acylated clionasterol glycosides from Valeriana officinalis.

    abstract::The chloroform extract of Valeriana officinalis led to the isolation of clionasterol-3-O-beta-D-glucopyranoside and a mixture of 6'-O-acyl-beta-D-glucosyl-clionasterols. The acyl moieties were identified as hexadecanoyl, 8 E,11 E-octadecadienoyl and 14-methylpentadecanoyl by alkaline hydrolysis followed by GC-MS analy...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pullela SV,Choi YW,Khan SI,Khan IA

    更新日期:2005-10-01 00:00:00