Abstract:
:A methanol extract of the leaves of Syzygium polyanthum (Wight) Walp. afforded four new acylbenzene derivatives (1-4) together with seven known compounds (5-11). The structures of 1-11 were elucidated by extensive spectroscopic methods and comparison with the literature data. The new compounds 1-3 and a known compound, campest-4-en-3-one (10), exhibited a significant protein tyrosine phosphatase 1B inhibitory activity with IC₅₀ values of 13.1 ± 0.1, 5.77 ± 0.15, 4.01 ± 0.26, and 10.4 ± 0.5 µM, respectively. The inhibitory potency of the new compounds 2 and 3 was comparable to that of a positive control RK-682 (IC₅₀, 5.51 ± 0.04 µM).
journal_name
Planta Medjournal_title
Planta medicaauthors
Saifudin A,Tanaka K,Kadota S,Tezuka Ydoi
10.1055/s-0032-1315000subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1378-81issue
12eissn
0032-0943issn
1439-0221journal_volume
78pub_type
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