Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants.

abstract：:Ent-11alpha-hydroxy-16-kauren-15-one (1) induced apoptosis in a human leukemia cell line (HL-60 cells), however, the apoptosis-inducing properties of 1 and its related compounds remain to be proved. We examined the involvement of caspases, a family of cysteine aspartic proteases, which play a central role in induction...

journal_title：Planta medica

authors： Nagashima F,Kondoh M,Kawase M,Simizu S,Osada H,Fujii M,Watanabe Y,Sato M,Asakawa Y

更新日期：2003-04-01 00:00:00

abstract：:Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatu...

journal_title：Planta medica

authors： Fürer K,Raith M,Brenneisen R,Mennet M,Simões-Wüst AP,von Mandach U,Hamburger M,Potterat O

更新日期：2013-11-01 00:00:00

abstract：:Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungus Epicoccum nigrum (strain 749) was found to produce the azaphilonoid compounds ...

journal_title：Planta medica

authors： Hufendiek P,Stölben SSM,Kehraus S,Merten N,Harms H,Crüsemann M,Arslan I,Gütschow M,Schneider T,König GM

更新日期：2017-08-01 00:00:00

abstract：:Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-beta-(2"-galloyl)-glucopyranoside and quercetin 3-O-beta-(2"-galloyl)-rhamnopyranoside, and a new compound, quer...

journal_title：Planta medica

authors： Kim Y,Jang DS,Park SH,Yun J,Min BK,Min KR,Lee HK

更新日期：2000-02-01 00:00:00

abstract：:(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione (1) was isolated from the fruiting bodies of Isaria japonica as an apoptosis-inducing agent. The complete structural assignment of the compound was accomplished on the basis of spectroscopic methods and chemical transformations. Compound 1...

journal_title：Planta medica

authors： Oh H,Kim T,Oh GS,Pae HO,Hong KH,Chai KY,Kwon TO,Chung HT,Lee HS

更新日期：2002-04-01 00:00:00

abstract：:Helanalin, a sesquiterpene lactone antineoplastic agent, is toxic at therapeutic doses in murine tumors. The toxicity has been assumed to be correlated with the binding of the drug to cellular thiol groups. Studies were undertaken to increase the intracellular level of GSH in the liver, kidney and other tissues to eli...

journal_title：Planta medica

authors： Hall IH,Grippo AA,Holbrook DJ,Roberts G,Lin HC,Kim HL,Lee KH

更新日期：1989-12-01 00:00:00

abstract：:Three new secoiridoid glucosides, jasamplexosides A, B and C, were isolated from the crude drug "Niu du teng", the leaves and stems of JASMINUM AMPLEXICAULE, together with the known secoiridoid glucosides, 10-hydroxyligstroside and jasminoside. Their structural elucidation by spectroscopic studies is described. ...

journal_title：Planta medica

authors： Tanahashi T,Shimada A,Nagakura N,Nayeshiro H

更新日期：1992-12-01 00:00:00

abstract：:Propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing proinflammatory cytokines. In order to demonstrate the anti-inflammatory effects and action mechanisms of magnolol and honokiol, several methods were employed....

journal_title：Planta medica

authors： Lee J,Jung E,Park J,Jung K,Lee S,Hong S,Park J,Park E,Kim J,Park S,Park D

更新日期：2005-04-01 00:00:00

abstract：:Two diterpenoids were prepared from hexane anti-inflammatory extracts of the Spanish herb Sideritis javalambrensis: ent-13-epi-12 alpha-acetoxymanoyl oxide (= "manoyl oxide F1") and ent-8 alpha-hydroxy-labda-13(16), 14-diene (= "labdane F2"). They were evaluated for possible anti-inflammatory actions in vitro in the c...

journal_title：Planta medica

authors： de las Heras B,Hoult JR

更新日期：1994-12-01 00:00:00

abstract：:Four new iridoids viz., plumeridoids A, B, and C and epiplumeridoid C were isolated from the stem bark of Plumeria rubra Linn. together with twenty-four known compounds viz., 1-( P-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, P- E-coumaric a...

journal_title：Planta medica

authors： Kuigoua GM,Kouam SF,Ngadjui BT,Schulz B,Green IR,Choudhary MI,Krohn K

更新日期：2010-04-01 00:00:00

abstract：:The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of ...

journal_title：Planta medica

authors： Fotsing MT,Yankep E,Njamen D,Fomum ZT,Nyasse B,Bodo B,Recio MC,Giner RM,Ríos JL

更新日期：2003-08-01 00:00:00

abstract：:Two new anthraquinones have been isolated from the seeds of PEGANUM HARMALA Linn and the structures established as 3,6-dihydroxy-8-methoxy-2-methylanthraquinone (peganone; 1) and 8-hydroxy-7-methoxy-2-methylanthraquinone (peganone; 2) by spectral correlations and chemical evidences. ...

journal_title：Planta medica

authors： Pitre S,Srivastava SK

更新日期：1987-02-01 00:00:00

abstract：:Bioassay-guided fractionation of the H(2)O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compo...

journal_title：Planta medica

authors： Cho H,Jun JY,Song EK,Kang KH,Baek HY,Ko YS,Kim YC

更新日期：2001-11-01 00:00:00

abstract：:The effects of phytoestrogens on the female breast are discussed controversially. On the one hand, epidemiological and experimental data provide evidence that dietary phytoestrogens may prevent the development of breast cancer. On the other hand, in breast cancer cell lines and tumour models isoflavone phytoestrogens ...

journal_title：Planta medica

authors： Hertrampf T,Schmidt S,Seibel J,Laudenbach-Leschowsky U,Degen GH,Diel P

更新日期：2006-03-01 00:00:00

abstract：:The aim of this study was to investigate the effect of demethylbellidifolin (DMB), a major xanthone compound of Swertia davidi franch, on nitroglycerin (NTG) tolerance. In the in vivo portion of the study, pretreatment of Sprague-Dawley rats with NTG (10 mg/kg) for 8 days caused tolerance to the depressor effect of NT...

journal_title：Planta medica

authors： Shi RZ,Li XH,Jia SJ,Fu QM,Chen YR,Chen J,Chen A,Li SX,Tan GS,Li YJ,Zhang GG

更新日期：2009-11-01 00:00:00

abstract：:The inhibition of butyrylcholinesterase activity in human serum by protoberberine, benzophenanthridine and aporphine alkaloids as well as four model compounds has been studied. The mechanism of the inhibition is discussed on the basis of the different types of interaction of these compounds with butyrylcholinesterase ...

journal_title：Planta medica

authors： Ulrichová J,Walterová D,Preininger V,Simánek V

更新日期：1983-07-01 00:00:00

abstract：:Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= cassyfiline) and actinodaphnine. Their structures were determined by analysis of spectroscopic data. All isolated alkaloids were tested for their cytot...

journal_title：Planta medica

authors： Stévigny C,Block S,De Pauw-Gillet MC,de Hoffmann E,Llabrès G,Adjakidjé V,Quetin-Leclercq J

更新日期：2002-11-01 00:00:00

abstract：:The effect of nitrogen and carbon sources on growth and diosgenin production was studied with Dioscorea deltoidea cells which were grown under defined conditions in a chemostat, and transferred to batch cultures. Both ammonium and nitrate nitrogen were required for growth and steroid production; diosgenin production w...

journal_title：Planta medica

authors： Tal B,Gressel J,Goldberg I

更新日期：1982-02-01 00:00:00

abstract：:From the defatted seeds of Cassia marginata fam (Caesalpinaceae) two new anthraquinone glycosides have been isolated and characterised as physcion-8-O-alpha-L-xylopyranoside and emodin-8-O-alpha-L-arabinopyranoside. ...

journal_title：Planta medica

authors： Duggal JK,Misra K

更新日期：1982-05-01 00:00:00

abstract：:Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1'-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by ana...

journal_title：Planta medica

authors： Chang CP,Chang HS,Peng CF,Lee SJ,Chen IS

更新日期：2011-01-01 00:00:00

abstract：:The anti-inflammatory activity of alpha-viniferin, a trimer of resveratrol, has been demonstrated in an animal model of carrageenin-induced paw edema, and inhibitory effects of the compound on cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) have been investigated in order to understand the mode of the ...

journal_title：Planta medica

authors： Chung EY,Kim BH,Lee MK,Yun YP,Lee SH,Min KR,Kim Y

更新日期：2003-08-01 00:00:00

abstract：:Hot water extract (ALR-0) of rhizomes of Atractylodes lanceo DC. was fractionated into MeOH-soluble fraction (ALR-1), supernatant fraction of EtOH precipitation (ALR-3 + 4), and crude polysaccharide fraction (ALR-5). Among these fractions, only ALR-5 showed potent stimulating activity for proliferation of bone marrow ...

journal_title：Planta medica

authors： Yu KW,Kiyohara H,Matsumoto T,Yang HC,Yamada H

更新日期：1998-12-01 00:00:00

abstract：:A new cytotoxic roridin-type trichothecene macrolide named roritoxin E(1) was characterized from the solid culture of Myrothecium roridum IFB-E091 (residing originally inside Artemisia annua root), together with the known compounds lumichrome (2), (22 E,24 S)-cerevisterol (3), and (22 E,24 R)-6 beta-methoxy-ergosta-7,...

journal_title：Planta medica

authors： Shen L,Wang JS,Shen HJ,Song YC,Tan RX

更新日期：2010-07-01 00:00:00

abstract：:A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibit...

journal_title：Planta medica

authors： Zhang SD,Qin JJ,Jin HZ,Yin YH,Li HL,Yang XW,Li X,Shan L,Zhang WD

更新日期：2012-01-01 00:00:00

abstract：:Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. Recently, rutaecarpine has been characterized to have an anti-inflammatory activity through cyclooxygenase-2 inhibition. In the present studies, the effects of rutaecarpine on liver cytochrome P450 s (P450s) and P450 s involved...

journal_title：Planta medica

authors： Lee SK,Kim NH,Lee J,Kim DH,Lee ES,Choi HG,Chang HW,Jahng Y,Jeong TC

更新日期：2004-08-01 00:00:00

abstract：:Olive mill waste water is the major byproduct of the olive oil industry containing a range of compounds related to Olea europaea and olive oil constituents. Olive mill waste water comprises an important environmental problem in olive oil producing countries, but it is also a valuable material for the isolation of high...

journal_title：Planta medica

authors： Vougogiannopoulou K,Angelopoulou MT,Pratsinis H,Grougnet R,Halabalaki M,Kletsas D,Deguin B,Skaltsounis LA

更新日期：2015-08-01 00:00:00

abstract：:The effects of four fractions, a hexane fraction, an ethyl acetate fraction, an N-butanol fraction and a water fraction, from a water extract of Herba Visci were investigated to find the fraction, in IN VITRO experiments, with the greatest ability to inhibit the formation of osteoclast-like multinucleated cells from m...

journal_title：Planta medica

authors： Yin J,Han N,Xu X,Liu Z,Zhang B,Kadota S

更新日期：2008-02-01 00:00:00

abstract：:The new I-3', II-3, 3', II-4', I-5, II-5, I-7, II-7-octahydroxy-I-4'-methoxy-I-3, II-8-biflavanone together with known biflavanones GB-1 and GB-2 were isolated from the bark of GARCINIA KOLA. ...

journal_title：Planta medica

authors： Kabangu K,Galeffi C,Aonzo E,Nicoletti M,Messana I

更新日期：1987-06-01 00:00:00

abstract：:We previously reported the isolation of eleven new cardiac glycosides called cheiranthosides I-XI together with two known ones (olitoriside and erysimoside) from the seeds of Erysimum cheiranthoides L. The glycosides were evaluated for their inhibitory activity against Na+,K(+)-ATPase by comparing with typical cardiac...

journal_title：Planta medica

authors： Lei ZH,Kuniyasu A,Tai BS,Nakayama H,Nohara T

更新日期：2001-06-01 00:00:00

abstract：:Emodin, chrysophanol and physcion have been shown to be the major anthraquinone pigments present in the dry roots of RUMEX ABYSINICA. ...

journal_title：Planta medica

authors： Munavu RM,Mudamba LO,Ogur JA

更新日期：1984-02-01 00:00:00