Flavonol glycoside gallate and ferulate esters from Persicaria lapathifolia as inhibitors of superoxide production in human monocytes stimulated by unopsonized zymosan.


:Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-beta-(2"-galloyl)-glucopyranoside and quercetin 3-O-beta-(2"-galloyl)-rhamnopyranoside, and a new compound, quercetin 3-O-beta-(6"-feruloyl)-galactopyranoside, were isolated as the inhibitors of superoxide production by activity-guided fractionation. IC50 values were shown at the concentrations of 2.1 microM by quercetin 3-O-beta-(2"-galloyl)-glucopyranoside, 1.9 microM by quercetin 3-O-beta-(2"-galloyl)-rhamnoypranoside, and 3.5 microM by quercetin 3-O-beta-(6"-feruloyl)-galactopyranoside whose inhibitory potencies were similar to oxyphenylbutazone (IC50 = 1.9 microM) as a positive control.


Planta Med


Planta medica


Kim Y,Jang DS,Park SH,Yun J,Min BK,Min KR,Lee HK




Has Abstract


2000-02-01 00:00:00












  • Diterpenes from Cryptomeria japonica inhibit androgen receptor transcriptional activity in prostate cancer cells.

    abstract::We identified eight diterpenes from Cryptomeria japonica (Taxodiaceae), which inhibit the activity of the androgen receptor (AR) in human prostate cancer (PCa) 22Rv1-derived 103E cells. The compounds 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one ( 2), sugiol ( 3), ferruginol ( 4), and 5-epixanthoperol ( 7) have near 10...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Tu WC,Wang SY,Chien SC,Lin FM,Chen LR,Chiu CY,Hsiao PW

    更新日期:2007-10-01 00:00:00

  • Anti-inflammatory Flavanones and Flavanols from the Roots of Pongamia pinnata.

    abstract::A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wen R,Lv H,Jiang Y,Tu P

    更新日期:2018-11-01 00:00:00

  • Metabolic Profiling of Saponin-Rich Ophiopogon japonicus Roots Based on 1H NMR and HPTLC Platforms.

    abstract::Ideally, metabolomics should deal with all the metabolites that are found within cells and biological systems. The most common technologies for metabolomics include mass spectrometry, and in most cases, hyphenated to chromatographic separations (liquid chromatography- or gas chromatography-mass spectrometry) and nucle...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ge Y,Chen X,Gođevac D,Bueno PCP,Salomé Abarca LF,Jang YP,Wang M,Choi YH

    更新日期:2019-08-01 00:00:00

  • An arabinogalactan-protein from cell culture of Malva sylvestris.

    abstract::An arabinogalactan-protein (AGP) from suspension culture medium of Malva sylvestris was isolated by precipitation with beta-glucosyl Yariv reagent, followed by gel-permeation chromatography. It revealed characteristic features of AGPs: a high amount of polysaccharide with a ratio of galactose to arabinose of 1.9 : 1, ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Classen B,Blaschek W

    更新日期:2002-03-01 00:00:00

  • Prevention of galactosamine-induced hepatic damage by picroliv: study on bile flow and isolated hepatocytes (ex vivo).

    abstract::Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3-12 mg/kg p.o. x 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Visen PK,Shukla B,Patnaik GK,Dhawan BN

    更新日期:1993-02-01 00:00:00

  • Evaluation of cytotoxic activity of Schisandra chinensis lignans.

    abstract::Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Smejkal K,Slapetová T,Krmenčík P,Babula P,Dall'Acqua S,Innocenti G,Vančo J,Casarin E,Carrara M,Kalvarová K,Dvorská M,Slanina J,Kramářová E,Julínek O,Urbanová M

    更新日期:2010-10-01 00:00:00

  • Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.

    abstract::During activity-guided fractionations to screen for antineoplastic agents, further studies by means of preparative HPLC led to the isolation of four known furostanol saponins: protoneodioscin, protodioscin, protoneogracillin, protogracillin, along with their corresponding artifacts: methyl protoneodioscin, methyl prot...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hu K,Dong A,Yao X,Kobayashi H,Iwasaki S

    更新日期:1997-04-01 00:00:00

  • Phthalides in the essential oil from roots of Levisticum officinale.

    abstract::The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustil...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Gijbels MJ,Scheffer JJ,Baerheim Svendsen A

    更新日期:1982-04-01 00:00:00

  • Taxol biosynthesis: an update.

    abstract::The novel diterpenoid taxol (paclitaxel) is now well-established as a potent chemotherapeutic agent. Total synthesis of the drug is not commercially feasible and, in the foreseeable future, the supply of taxol and its synthetically useful progenitors must rely on biological methods of production. The first three steps...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Hezari M,Croteau R

    更新日期:1997-08-01 00:00:00

  • New azaphilones and chlorinated phenolic glycosides from Chaetomium elatum with caspase-3 inhibitory activity.

    abstract::Three new azaphilones, chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3), and two new chlorinated phenolic glycosides, globosumoside A (4) and globosumoside B (5), were isolated from the crude extract of the fungal strain Chaetomium elatum No. 89-1-3-1. Their structures were determin...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chen GD,Li YJ,Gao H,Chen Y,Li XX,Li J,Guo LD,Cen YZ,Yao XS

    更新日期:2012-10-01 00:00:00

  • Antimicrobial, cytotoxic lignans and terpenoids from the twigs of Pseudolarix kaempferi.

    abstract::Seven new compounds, including four lignans, (+)-(8S,8′S)-9,9′-dibenzoylsecoisolariciresinol (1), (+)-(8S*,8′R*)-4,4′-dimethyloxomatairesinol (2), (+)-(7S*,8R*,8′R*,9′S*)-9′-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6),...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: He WJ,Chu HB,Zhang YM,Han HJ,Yan H,Zeng GZ,Fu ZH,Olubanke O,Tan NH

    更新日期:2011-11-01 00:00:00

  • The structure and the stereochemistry of atractyliretin.

    abstract::The nor-kaurane diterpene Atractyliretin was obtained by acid hydrolysis of Atractyloside, a toxic substance isolated from ATRACTYLIS GUMMIFERA L (Compositae). On the basis of spectral (IR, (1)H-NMR, (13)C-NMR and MS) analysis and chemical degradation its structure and stereochemistry was identified as 4. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Camarda L,Ceraulo L,Ferrugia M,Pascual C,Sprio V

    更新日期:1986-10-01 00:00:00

  • Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

    abstract::A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum....

    journal_title:Planta medica

    pub_type: 信件


    authors: Ahn KS,Sim WS,Lee IK,Seu YB,Kim IH

    更新日期:1997-08-01 00:00:00

  • Inhibitory activities of lichen-derived compounds against methicillin- and multidrug-resistant Staphylococcus aureus.

    abstract::The inhibitory effects of selected phenolic lichen substances were tested against a panel of methicillin- and multidrug-resistant Staphylococcus aureus. Depsidones with long alkyl chains on both of the aromatic rings were consistently active against the strains tested, comparable to or better than the level of clinica...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kokubun T,Shiu WK,Gibbons S

    更新日期:2007-02-01 00:00:00

  • Fractionation and chemical properties of immunomodulating polysaccharides from roots of Dipsacus asperoides.

    abstract::A crude polysaccharide fraction (DAP-1) was prepared from roots of Dipsacus asperoides by hot water extraction and EtOH precipitation, and tested for anti-complementary activity, mitogenic activity of lymphocytes, and effects on acid phosphatase and phagocytic activities of macrophages. DAP-1 showed not only anti-comp...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang Y,Kiyohara H,Matsumoto T,Yamada H

    更新日期:1997-10-01 00:00:00

  • MicroRNAs as New Bioactive Components in Medicinal Plants.

    abstract::Herbal medicine has been used to treat diseases for centuries; however, the biological active components and the mechanistic understanding of actions of plant-derived drugs are permanently discussed. MicroRNAs are a class of small, non-coding RNAs that play crucial roles as regulators of gene expression. In recent yea...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Xie W,Weng A,Melzig MF

    更新日期:2016-08-01 00:00:00

  • Dysoxydensins A-G, seven new clerodane diterpenoids from Dysoxylum densiflorum.

    abstract::Seven new clerodane diterpenoids, dysoxydensins A-G (1-7), together with six known clerodanes, were isolated from Dysoxylum densiflorum. The structures of all the compounds were elucidated by extensive spectroscopic analysis. These compounds were evaluated for their cytotoxic activities against five human cancer cell ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Gu J,Cheng GG,Qian SY,Li Y,Liu YP,Luo XD

    更新日期:2014-08-01 00:00:00

  • Conferone from Ferula schtschurowskiana enhances vinblastine cytotoxicity in MDCK-MDR1 cells by competitively inhibiting P-glycoprotein transport.

    abstract::Overexpression of the protein transporter P-glycoprotein (Pgp, MDR1) at the cell surface is a major cause of multidrug resistance (MDR) and poor response to treatment in cancer chemotherapy and therapy for leishmaniasis. The present study shows that conferone, a sesquiterpene coumarin ether isolated for the first time...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Barthomeuf C,Demeule M,Grassi J,Saidkhodjaev A,Beliveau R

    更新日期:2006-06-01 00:00:00

  • Investigation of the Alkaloid Content of Rauwolfia serpentina Roots from Regenerated Plants.

    abstract::The indole alkaloid content of RAUWOLFIA SERPENTINA roots from regenerated plants (from stem-and root-callus) was compared with the parental stock. Although the total alkaloid content seems to be slightly higher in the roots from regenerated plants, HPLC-analysis of individual alkaloids indicated that the contents of ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ruyter CM,Akram M,Illahi I,Stöckigt J

    更新日期:1991-08-01 00:00:00

  • Enhancement of the fungicidal activity of amphotericin B by allicin, an allyl-sulfur compound from garlic, against the yeast Saccharomyces cerevisiae as a model system.

    abstract::Amphotericin B (AmB) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin, an allyl-sulfur compound from garlic. In addition to the plasma membrane permeability change, AmB induced vacuole membrane damage so that the organelles were vi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ogita A,Fujita K,Taniguchi M,Tanaka T

    更新日期:2006-10-01 00:00:00

  • Cytotoxic and antifungal isoprenylated xanthones and flavonoids from Cudrania fruticosa.

    abstract::A new isoprenylated xanthone, cudrafrutixanthone A, was isolated from the roots of Cudrania fruticosa, together with 18 known compounds. Their structures were elucidated by spectroscopic methods. Most isoprenylated xanthones exhibited cytotoxicity against HCT-116, SMMC-7721, SGC-7901, and BGC-823 cell lines with IC (5...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang YH,Hou AJ,Zhu GF,Chen DF,Sun HD

    更新日期:2005-03-01 00:00:00

  • Molecular authentication of the traditional dai medicinal plant Croton caudatus.

    abstract::Croton caudatus is an important species in Dai folk medicine. Some other Croton species, in particular, C. kongensis, C. cascarilloides, C. crassifolius, C. lachnocarpus and C. olivaceus are often marketed as C. caudatus, and thus, the therapeutic effects of C. caudatus are not achieved. The respective morphological f...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xue HG,Zhou SD,He XJ,Yu Y

    更新日期:2007-06-01 00:00:00

  • Cryptic and free skin irritants of the daphnane and tigliane types in latex of Excoecaria agallocha.

    abstract::In the extremely skin irritant and caustic latex of Excoecaria agallocha the major part of the polyfunctional diterpene esters (DTE) (group I) are aliphatic polyunsaturated 9,13,14-orthoesters of the daphnane-type parent alcohol 5 beta-hydroxyresiniferonol-6 alpha, 7 alpha-epoxide, esterified simultaneously in their 2...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Karalai C,Wiriyachitra P,Opferkuch HJ,Hecker E

    更新日期:1994-08-01 00:00:00

  • Cardioprotection and matrix metalloproteinase-9 regulation of salvianolic acids on myocardial infarction in rats.

    abstract::Acute myocardial infarction (AMI) remains the leading cause of mortality in the world. Early intervention using salvianolic acids (SA) can substantially improve clinical outcomes. However, in spite of the great achievements that have been made in elucidating the protective effects of SA on AMI, the effects of SA on th...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jiang B,Wu W,Li M,Xu L,Sun K,Yang M,Guan S,Liu X,Guo DA

    更新日期:2009-10-01 00:00:00

  • Alterations in sulfur amino acid metabolism in mice treated with silymarin: a novel mechanism of its action involved in enhancement of the antioxidant defense in liver.

    abstract::It has been known that silymarin exhibits protective activity against oxidative liver injury induced by various hepatotoxicants, but the underlying mechanism of its beneficial action remains unclear. We determined the alterations in sulfur-containing amino acid metabolism induced by silymarin in association with its e...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kwon DY,Jung YS,Kim SJ,Kim YS,Choi DW,Kim YC

    更新日期:2013-08-01 00:00:00

  • Eremophilane sesquiterpene lactones from Ligularia virgaurea ssp. oligocephala.

    abstract::From an extract of the whole plant of Ligularia virgaurea ssp. oligocephala, three new eremophilane sesquiterpene lactones, 10alpha-hydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (1), 6alpha,10alpha-dihydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (2), 6beta,10beta-dihydroxyeremophila-7(11),8(9)-dien-12,8-olid...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wu QX,Shi YP,Yang L

    更新日期:2004-05-01 00:00:00

  • Aquaticol, a bis-sesquiterpene and iridoid glucosides from Veronica anagallis-aquatica.

    abstract::Aquaticol, an unusual bis-sesquiterpene was isolated from the medicinal plant Veronica anagallis-aquatica, in addition to 11 known compounds, aucubin, geniposidic acid, mussaenoside, catalposide, verproside, amphicoside, catalpol, boschnaloside, shanzhiside methyl ester, sitosterol and beta-stigmast-4-en-6 beta-ol-3-o...

    journal_title:Planta medica

    pub_type: 信件


    authors: Su BN,Yang L,Gao K,Jia ZJ

    更新日期:2000-04-01 00:00:00

  • Silibinin in vitro protects A549 cells from Staphylococcus aureus-mediated injury and in vivo alleviates the lung injury of staphylococcal pneumonia.

    abstract::In this study, hemolysis, Western blot, and real-time RT-PCR assays were performed to evaluate silibinin's activity against S. aureus α-toxin secretion. In addition, live/dead cell staining and lactate dehydrogenase activity assays were introduced to examine the influence of silibinin on α-toxin-induced cell injury in...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang X,Dong J,Dai X,Zhang Y,Wang J,Li H,Lu C,Tan W,Gao X,Deng X,Bu S,Niu X

    更新日期:2013-01-01 00:00:00

  • Effects of 7-epiclusianone on Streptococcus mutans and caries development in rats.

    abstract::The aim of this study was to evaluate the effects of 7-epiclusianone (7-epi) on specific virulence attributes of Streptococcus mutans in vitro and on development of dental caries in vivo. 7-Epi was obtained and purified from fruits of Rheedia brasiliensis. We investigated its influence on surface-adsorbed glucosyltran...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Branco-de-Almeida LS,Murata RM,Franco EM,dos Santos MH,de Alencar SM,Koo H,Rosalen PL

    更新日期:2011-01-01 00:00:00

  • Effect of astilbin on experimental diabetic nephropathy in vivo and in vitro.

    abstract::Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. This study was conducted to investigate the efficacy of astilbin on experimental diabetic nephropathy (DN) in vivo and in vitro and its possible mechanisms. Astilbin was added in high glucose stimulated HK-2 cells, streptozotocin-indu...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Li GS,Jiang WL,Yue XD,Qu GW,Tian JW,Wu J,Fu FH

    更新日期:2009-11-01 00:00:00