Abstract:
:Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known sesquiterpenoid, 1alpha,7alpha,10alpha H-guaia-4,11-dien-3-one ( 24) were revised by 2D NMR techniques. Among the isolates, three compounds, (+)-hinokinin ( 6), 2,6-dimethoxy- p-benzoquinone ( 17), and 1alpha,7alpha,10alpha H-guaia-4,11-dien-3-one ( 24) exhibited effective cytotoxicities (ED50 values < 4.0 microg mL-1) against P-388 and HT-29 tumor cell lines.
journal_name
Planta Medjournal_title
Planta medicaauthors
Lin RW,Tsai IL,Duh CY,Lee KH,Chen ISdoi
10.1055/s-2004-815540subject
Has Abstractpub_date
2004-03-01 00:00:00pages
234-8issue
3eissn
0032-0943issn
1439-0221journal_volume
70pub_type
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