Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations.

abstract：:Helanalin, a sesquiterpene lactone antineoplastic agent, is toxic at therapeutic doses in murine tumors. The toxicity has been assumed to be correlated with the binding of the drug to cellular thiol groups. Studies were undertaken to increase the intracellular level of GSH in the liver, kidney and other tissues to eli...

journal_title：Planta medica

authors： Hall IH,Grippo AA,Holbrook DJ,Roberts G,Lin HC,Kim HL,Lee KH

更新日期：1989-12-01 00:00:00

abstract：:Eschsholzia californica Cham. is a traditional medicinal plant of the Indians used by the rural population of California for its analgesic and sedative properties. Our study on the aqueous extract shows that this plant reduced the behavioural parameters measured in a familiar environment test in mice (novelty preferen...

journal_title：Planta medica

authors： Rolland A,Fleurentin J,Lanhers MC,Younos C,Misslin R,Mortier F,Pelt JM

更新日期：1991-06-01 00:00:00

abstract：:The absolute stereostructure of a novel skeletal diterpene, standishinal (1), from the bark of Thuja standishii was confirmed by X-ray crystallographic analyses of 1 and its p-bromobenzoate derivative. Aromatase inhibitory activities of standishinal, eight known diterpenes, totarol, 12-methoxyabieta-8,11,13-trien-11-o...

journal_title：Planta medica

authors： Minami T,Iwamoto M,Ohtsu H,Ohishi H,Tanaka R,Yoshitake A

更新日期：2002-08-01 00:00:00

abstract：:A systematic structure-activity relationship of 3beta-hydroxy-27- P- E-coumaroyloxyurs-12-en-28-oic acid ( 7), a triterpene ester isolated from UNCARIA RHYNCHOPHYLLA as a phospholipase Cgamma1 inhibitor, was undertaken with a view toward elucidating its chemical mode of action on PLCgamma1. Related derivatives and ana...

journal_title：Planta medica

authors： Lee JS,Yoo H,Suh YG,Jung JK,Kim J

更新日期：2008-10-01 00:00:00

abstract：:Some diterpenoids show various biological activities, including anti-inflammatory, anti-HIV and anti-tumor activity. Previously, we have focused our research on the apoptosis-inducing properties of diterpenoids and found that some ent-kaurene-type diterpenoids induced apoptosis in human leukemia HL-60 cells. In this s...

journal_title：Planta medica

authors： Kondoh M,Nagashima F,Suzuki I,Harada M,Fujii M,Asakawa Y,Watanabe Y

更新日期：2005-11-01 00:00:00

abstract：:A known sesquiterpene lactone, encelin, isolated from the Mexican species Montanoa speciosa (Compositae), was assayed for biocidal activity on fungal cells of Mucor rouxii. The results indicate that encelin has a determining action on growth and the morphogenetic process of fungal cells. ...

journal_title：Planta medica

authors： Sabanero M,Quijano L,Rios T,Trejo R

更新日期：1995-04-01 00:00:00

abstract：:Scopoletin exhibited an immediate and dose-dependent hypouricemic effect after intraperitoneal administration (50, 100, 200 mg/kg) in hyperuricemic mice induced by potassium oxonate; however, it did not affect the serum uric acid level in normal mice at the tested doses. For exploring the involved mechanisms of action...

journal_title：Planta medica

authors： Ding Z,Dai Y,Wang Z

更新日期：2005-02-01 00:00:00

abstract：:Verbascoside is a phenylethanoid glycoside widely distributed in nature, especially among the order Lamiales, occurring in numerous plants that are constituents of folk medicine preparations. This natural compound, previously isolated by our group from the ethyl acetate extract of Lantana trifolia using the gradient a...

journal_title：Planta medica

authors： Leitão GG,Pinto SC,de Oliveira DR,Timoteo P,Guimarães MG,Cordova WH,Leitão SG

更新日期：2015-11-01 00:00:00

abstract：:The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as health supplement or herbal medicine worldwide. To study the beneficial role of jujube in enhancing hematopoietic function, we investigated its roles on the expression of erythropoietin in cultured Hep3B human hepatocellular c...

journal_title：Planta medica

authors： Chen J,Lam CT,Kong AY,Zhang WL,Zhan JY,Bi CW,Chan GK,Lam KY,Yao P,Dong TT,Tsim KW

更新日期：2014-11-01 00:00:00

abstract：:The 80% and 70% acetone extracts from fruits and leaves of Crataegus sinaica Boiss (Rosaceae) and the ethyl acetate-, butanol-, and water-fractions obtained from these initial extracts as well as the isolated compounds, quercetin (1) (1), hyperoside (quercetin 3-O-galactoside) (2) (2), rutin (quercetin 3-O-rutinoside)...

journal_title：Planta medica

authors： Shahat AA,Hammouda F,Ismail SI,Azzam SA,De Bruyne T,Lasure A,Van Poel B,Pieters L,Vlietinck AJ

更新日期：1996-02-01 00:00:00

abstract：:Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J....

journal_title：Planta medica

authors： Saab AM,Guerrini A,Sacchetti G,Maietti S,Zeino M,Arend J,Gambari R,Bernardi F,Efferth T

更新日期：2012-12-01 00:00:00

abstract：:The effects of four fractions, a hexane fraction, an ethyl acetate fraction, an N-butanol fraction and a water fraction, from a water extract of Herba Visci were investigated to find the fraction, in IN VITRO experiments, with the greatest ability to inhibit the formation of osteoclast-like multinucleated cells from m...

journal_title：Planta medica

authors： Yin J,Han N,Xu X,Liu Z,Zhang B,Kadota S

更新日期：2008-02-01 00:00:00

abstract：:Cannabis (Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two major phytocannabinoids accounting for over 40% of the cannabis plant extracts, depending on the variety. At the University of Mississippi, differ...

journal_title：Planta medica

authors： Ibrahim EA,Gul W,Gul SW,Stamper BJ,Hadad GM,Abdel Salam RA,Ibrahim AK,Ahmed SA,Chandra S,Lata H,Radwan MM,ElSohly MA

更新日期：2018-03-01 00:00:00

abstract：:Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropa...

journal_title：Planta medica

authors： Chen JJ,Duh CY,Chen IS

更新日期：1999-10-01 00:00:00

abstract：:Hepatocellular carcinoma is one of the leading causes of malignancy-related death in China. Its therapy in clinics is a big challenge. Ginsenoside Rh2 is one of the most notable cancer-preventing components from red ginseng and it has been reported that ginsenoside Rh2 exhibited potent cytotoxicity against human hepat...

journal_title：Planta medica

authors： Lv Q,Rong N,Liu LJ,Xu XL,Liu JT,Jin FX,Wang CM

更新日期：2016-05-01 00:00:00

abstract：:One new diterpene, 2 alpha-hydroxy-12beta-hydroxy-isopimara-8(14), 15-diene, and six known compounds as triterpenes, sterols and fatty acid, were isolated from the stem bark of Tanaecium jaroba (Bignoniaceae), a Bolivian plant used in traditional medicine. Their structures were established mainly by 1D and 2D NMR (COS...

journal_title：Planta medica

authors： Mitaine-Offer AC,Sauvain M,Deharo E,Muñoz V,Zèches-Hanrot M

更新日期：2002-06-01 00:00:00

abstract：:The antimycobacterial quinolones 1-methyl-2-undecyl-4-quinolone, dihydroevocarpine and evocarpine as well as the indoloquinazoline alkaloids rutaecarpine and evodiamine - all from the Chinese medicinal herb Evodia rutaecarpa - were tested in two in vitro assays, for cytotoxicity and interaction with p-glycoprotein (p-...

journal_title：Planta medica

authors： Adams M,Mahringer A,Kunert O,Fricker G,Efferth T,Bauer R

更新日期：2007-12-01 00:00:00

abstract：:Ent-11alpha-hydroxy-16-kauren-15-one (1) induced apoptosis in a human leukemia cell line (HL-60 cells), however, the apoptosis-inducing properties of 1 and its related compounds remain to be proved. We examined the involvement of caspases, a family of cysteine aspartic proteases, which play a central role in induction...

journal_title：Planta medica

authors： Nagashima F,Kondoh M,Kawase M,Simizu S,Osada H,Fujii M,Watanabe Y,Sato M,Asakawa Y

更新日期：2003-04-01 00:00:00

abstract：:In addition to 7-methoxy-2-methyl-3,4,5-trihydroxyanthraquinone (1), physcion (2), macrosporin (3), deoxybostrycin (4), altersolanol B (5) and dactylariol (6), a new hexahydroanthraquinone named pleospdione (7) was isolated from the culture of Pleospora sp . IFB-E006, an endophytic fungus residing in the normal stem o...

journal_title：Planta medica

authors： Ge HM,Song YC,Shan CY,Ye YH,Tan RX

更新日期：2005-11-01 00:00:00

abstract：:The essential oil composition of three Zingiberaceae widely used as medicinal aromatic plants from S. Tomé and Príncipe: Aframomum danielli (Hook. f.) K. Schum., Curcuma longa L. and Zingiber officinale Rosc. was studied. Two samples of the essential oils from fruit of A. danielli and from rhizomes of the other two sp...

journal_title：Planta medica

authors： Martins AP,Salgueiro L,Gonçalves MJ,da Cunha AP,Vila R,Cañigueral S,Mazzoni V,Tomi F,Casanova J

更新日期：2001-08-01 00:00:00

abstract：:Magnesium lithospermate B (MLB), sodium rosmarinate (SR), and magnesium lithospermate (ML) are biologically active components isolated from aqueous extracts of the Chinese medicine Danshen, the dried root and rhizome of SALVIA MILTIORRHIZA Bunge (Labiatae). These compounds share similar chemical structures of polyphen...

journal_title：Planta medica

authors： Chen L,Xuan LJ,Wang YP

更新日期：2009-12-01 00:00:00

abstract：:The isoflavonoids found in soy have attracted great interest as dietary phytoestrogens that might be effective for postmenopausal hormone replacement therapy. Special attention has been devoted to the hormonal effects of various isoflavonoids, like genistein (GEN) and daidzein's (DAID) potent metabolite, equol (EQ). H...

journal_title：Planta medica

authors： Tezval M,Sehmisch S,Seidlová-Wuttke D,Rack T,Kolios L,Wuttke W,Stuermer KM,Stuermer EK

更新日期：2010-02-01 00:00:00

abstract：:Geniposide, a main iridoid glucoside component of gardenia fruit, has been shown to possess anti-inflammatory activity. However, its potential use for acute lung injury (ALI) has not yet been studied. The aim of this study was to evaluate the anti-inflammatory properties of geniposide using a mouse ALI model. ALI was ...

journal_title：Planta medica

authors： Xiaofeng Y,Qinren C,Jingping H,Xiao C,Miaomiao W,Xiangru F,Xianxing X,Meixia H,Jing L,Jingyuan W,Xinxin C,Hongyu L,Yanhong D,Lanxiang J,Xuming D

更新日期：2012-04-01 00:00:00

abstract：:Six new triterpenoids including four new secodammarane triterpenoid glycosides (1-4), an epoxydammarane triterpenoid glycoside (5), and a new secodammarane triterpenoid (6) were isolated from the ethanolic extract of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic ...

journal_title：Planta medica

authors： Li S,Cui B,Liu Q,Tang L,Yang Y,Jin X,Shen Z

更新日期：2012-02-01 00:00:00

abstract：:In the present study, we attempted to compare quercetin methyl ethers and to look for the structure-activity relationships, which may be helpful for synthesizing more active compounds for the treatment of asthma. Four present and two previously studied quercetin methyl ethers concentration-dependently relaxed histamin...

journal_title：Planta medica

authors： Ko WC,Kuo SW,Sheu JR,Lin CH,Tzeng SH,Chen CM

更新日期：1999-04-01 00:00:00

abstract：:During the seasons 1989-1993, Valeriana officinalis plants were investigated for their contents of essential oil, valerenic acid and derivatives, and valepotriates. Harvesting of the subterranean parts was started in August of the year in which the seeds were sown, and continued until the last week of April of the sub...

journal_title：Planta medica

authors： Bos R,Woerdenbag HJ,van Putten FM,Hendriks H,Scheffer JJ

更新日期：1998-03-01 00:00:00

abstract：:Agnus Castus Fruit is defined in the European Pharmacopoeia as the dried ripe fruit of Vitex agnus-castus. In Europe it is used as a medicine targeting premenstrual syndrome and climacteric disorder. In Japan, Agnus Castus Fruit is becoming popular as a raw material for over-the-counter drugs and health food products,...

journal_title：Planta medica

authors： Oshima N,Masada S,Suzuki R,Yagi K,Matsufuji H,Suenaga E,Takahashi Y,Yahagi T,Watanabe M,Yahara S,Iida O,Kawahara N,Maruyama T,Goda Y,Hakamatsuka T

更新日期：2016-01-01 00:00:00

abstract：:Indole alkaloid contents were investigated in leaves of Tabernaemontana pachysiphon (Apocynaceae) trees in the natural habitat, Shimba Hills National Reserve, Kenya. The contents of the major alkaloids apparicine, tubotaiwine, tubotaiwine- N-oxide, and isovoacangine varied with site, leaf age, leaf growth form, positi...

journal_title：Planta medica

authors： Höft M,Verpoorte R,Beck E

更新日期：1998-03-01 00:00:00

abstract：:A new resveratrol dimer, (+)-vitisinol E (1) which demonstrated inhibitory activity on BACE-1 (beta-site APP-cleaving enzyme 1) in vitro, was isolated from the stembark extract of Vitis vinifera (Vitaceae) together with four known resveratrol oligomers, (+)-epsilon-viniferin (2), (+)-ampelopsin A (3), (+)-vitisin A (4...

journal_title：Planta medica

authors： Choi YH,Yoo MY,Choi CW,Cha MR,Yon GH,Kwon DY,Kim YS,Park WK,Ryu SY

更新日期：2009-04-01 00:00:00

abstract：:This review describes the current status of the development of techniques combining liquid chromatography and nuclear magnetic resonance and their use in the context of natural products. HPLC-NMR methods have a rapidly growing impact on natural products research by enabling structure determination of natural products ...

journal_title：Planta medica

authors： Jaroszewski JW

更新日期：2005-08-01 00:00:00