Abstract:
:Enzymatic thrombin activity is significantly inhibited only by a few selected natural phenolic compounds (myricetin, rosmarinic acid, caffeic acid phenethyl ester) but more strongly by unsaturated fatty acids like erucic acid and oleic acids. Compared to the inhibitory potential against neutrophil elastase, thrombin activity is rather weakly inhibited by phenolic compounds and fatty acids. Because of the importance of thrombin as a ligand for protease-activated receptor 1 (PAR-1), which is involved in inflammation, the inhibition of thrombin activity by natural compounds might enhance the anti-inflammatory effects of neutrophil elastase inhibition.
journal_name
Planta Medjournal_title
Planta medicaauthors
Melzig MF,Henke Kdoi
10.1055/s-2005-871253subject
Has Abstractpub_date
2005-08-01 00:00:00pages
787-9issue
8eissn
0032-0943issn
1439-0221journal_volume
71pub_type
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