Taxol and related compounds in Korean native yews (Taxus cuspidata).


:The concentrations of taxol and related compounds in the bark and needles of Taxus cuspidata grown on Mt. Jiri, Mt. Sobaek, and Cheju Island, and T. cuspidata var. latifolia on Ullung Island in Korea were determined by high performance liquid chromatography (HPLC). The taxane content significantly varied with the location and plant part. The taxol content in the bark of native yews from Mt. Jiri and Mt. Sobaek was high when compared to that reported for Pacific yew (T. brevifolia), whereas bark from trees on Cheju and Ullung islands contained a much lower level. Surprisingly, the needles from Cheju and Ullung islands contained a much higher level of taxol (0.022% and 0.0173%, respectively) than those of intermountain locations (0.0058% to 0.0085%), on the basis of dry weight. The bark and needles of T. cuspidata var. latifolia on Ullung Island also contained relatively high concentrations of 10-deacetylbaccatin III, 0.0497% and 0.0545%, respectively, and indicated that environmental factors may affect the quantity. Taxol in the needles was confirmed by electrospray mass spectrometry. These results suggest that foliage from yew trees growing in their natural habitats on Cheju and Ullung islands may provide a renewable source for taxol.


Planta Med


Planta medica


Choi MS,Kwak SS,Liu JR,Park YG,Lee MK,An NH




Has Abstract


1995-06-01 00:00:00












  • Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza.

    abstract::The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release o...

    journal_title:Planta medica

    pub_type: 信件


    authors: Ryu SY,Oak MH,Kim KM

    更新日期:1999-10-01 00:00:00

  • Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea.

    abstract::Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines shoul...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Guzmán-Gutiérrez SL,Silva-Miranda M,Krengel F,Huerta-Salazar E,León-Santiago M,Díaz-Cantón JK,Espitia Pinzón C,Reyes-Chilpa R

    更新日期:2020-05-11 00:00:00

  • Re-introduction of kava (Piper methysticum) to the EU: is there a way forward?

    abstract::Kava (Piper methysticum) is an effective anxiolytic that has been withdrawn from various consumer markets in European countries due to concerns over its hepatotoxicity. It is plausible that the reported hepatotoxicity may be due in part to plant substitution, or an incorrect cultivar, or plant parts being used (such a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sarris J,Teschke R,Stough C,Scholey A,Schweitzer I

    更新日期:2011-01-01 00:00:00

  • Glutathione adducts of helenalin and 11 alpha,13-dihydrohelenalin acetate inhibit glutathione S-transferase from horse liver.

    abstract::The 2-mono- and 2,13-bis-glutathionyl adducts of helenalin and the 2-monoglutathionyl adduct of 11 alpha,13-dihydrohelenalin acetate were previously shown to be formed by spontaneous Michael addition at physiological pH. In living cells, glutathione (GSH) conjugation of many types of electrophilic agents is catalysed ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Schmidt TJ

    更新日期:2000-03-01 00:00:00

  • Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity.

    abstract::Extracts from Pygeum africanum, Serenoa repens and Cucurbita pepo are used in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The activity of the androgen receptor (AR) is known to control growth of the prostate. Here, we examined extracts of these plants for their antiandrogenic activit...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Schleich S,Papaioannou M,Baniahmad A,Matusch R

    更新日期:2006-07-01 00:00:00

  • Aged garlic extract and its constituents inhibit Cu(2+)-induced oxidative modification of low density lipoprotein.

    abstract::Oxygen radical injury and lipid peroxidation have been suggested as major causes of atherosclerosis, cancer, liver disease, and the aging process. More specifically, oxidative modification of low density lipoprotein (LDL) has been recognized as an important process of atherosclerosis. In this study, we determined the ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Ide N,Nelson AB,Lau BH

    更新日期:1997-06-01 00:00:00

  • High frequency plant regeneration from leaf derived callus of high Δ9-tetrahydrocannabinol yielding Cannabis sativa L.

    abstract::An efficient in vitro propagation protocol for rapidly producing Cannabis sativa plantlets from young leaf tissue was developed. Using gas chromatography-flame ionization detection (GC-FID), high THC yielding elite female clone of a drug-type CANNABIS variety (MX) was screened and its vegetatively propagated clones we...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lata H,Chandra S,Khan IA,Elsohly MA

    更新日期:2010-10-01 00:00:00

  • Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative.

    abstract::Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungus Epicoccum nigrum (strain 749) was found to produce the azaphilonoid compounds ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hufendiek P,Stölben SSM,Kehraus S,Merten N,Harms H,Crüsemann M,Arslan I,Gütschow M,Schneider T,König GM

    更新日期:2017-08-01 00:00:00

  • Purification and biochemical characterization of a novel allergenic protein from tatary buckwheat seeds.

    abstract::An allergenic protein from tatary buckwheat seeds, designated TBt, was purified by salting out, anion exchange chromatography and size exclusion chromatography (SEC). Analysis by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and SEC showed that the allergenic protein was composed of two subunits...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang X,Cui X,Li Y,Wang Z

    更新日期:2008-12-01 00:00:00

  • New sesquiterpene lactones with antibacterial activity from Vernonia fastigiata.

    abstract::Sesquiterpene lactones 1-5 were isolated for the first time from the ethyl acetate of Vernonia fastigiata (Asteraceae). Compounds 3, 4 and 5 are new, compounds 1 and 2 have been found earlier in other Vernonia species but not in V. fastigiata. ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Roos G,Prawat H,Walter CU,Klaiber I,Vogler B,Guse JH,Kraus W

    更新日期:1998-10-01 00:00:00

  • Induction of apoptosis and G2/M cell cycle arrest by Gleditsioside E from Gleditsia sinensis in HL-60 cells.

    abstract::Gleditsioside E, a triterpene saponin isolated from Gleditsia sinensis, showed significant cytotoxicity against Bel-7402, BGC-823, HeLa, HL-60 and MCF-7 cell lines. The results of flow cytometry with annexin V-FITC/PI double staining proved that gleditsioside E mainly induced early apoptosis in HL-60 cells. Gleditsios...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhong L,Qu G,Li P,Han J,Guo D

    更新日期:2003-06-01 00:00:00

  • Determination of naphthazarin derivatives in endemic Turkish Alkanna species by reversed phase high performance liquid chromatography.

    abstract::The quantification of free and total alkannins in 13 endemic Anatolian Alkanna species is described for the first time. Extraction of the samples was performed by sonication with hexane, followed by hydrolysis in 1 N NaOH. For analysis, a new HPLC method, utilizing reversed phase material (Synergi Max RP), was develop...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pekin G,Ganzera M,Senol S,Bedir E,Korkmaz KS,Stuppner H

    更新日期:2007-03-01 00:00:00

  • Marine Metabolites Modulating CB Receptors and TRP Channels.

    abstract::Transient receptor potential channels and cannabinoid receptors are deputed to the regulation of sensory, homeostatic, and inflammatory events in the human organism. Therefore, their modulation promises to have relevant applications in important therapeutic areas such as inflammation, pain, and cancer. This review sum...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Rigano D,Formisano C,Taglialatela-Scafati O

    更新日期:2016-06-01 00:00:00

  • Antiproliferative effects of abietane diterpenes from Aegiphila lhotzkyana.

    abstract::Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as uncinatone, cyrtophyllone B, teunvicenone E, sugiol and 12,16-epoxy-11,14-dihydroxy-6-methoxy-17(15 - 16)- abeo-abieta-5,8, 11,13,15-pentaene-3,7-dione. The last compound has only been describ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Costa-Lotufo LV,Silveira ER,Barros MC,Lima MA,De Moraes ME,De Moraes MO,Pessoa C

    更新日期:2004-02-01 00:00:00

  • Assessment of cannabinoids content in micropropagated plants of Cannabis sativa and their comparison with conventionally propagated plants and mother plant during developmental stages of growth.

    abstract::Gas chromatography-flame ionization detection (GC-FID) was used to assess the chemical profile and quantification of cannabinoids to identify the differences, if existing, in the chemical constituents of in vitro propagated plants (IVP), conventionally grown plants (VP) and indoor grown mother plants (MP-Indoor) of a ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chandra S,Lata H,Mehmedic Z,Khan IA,ElSohly MA

    更新日期:2010-05-01 00:00:00

  • Enhancement of the fungicidal activity of amphotericin B by allicin, an allyl-sulfur compound from garlic, against the yeast Saccharomyces cerevisiae as a model system.

    abstract::Amphotericin B (AmB) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin, an allyl-sulfur compound from garlic. In addition to the plasma membrane permeability change, AmB induced vacuole membrane damage so that the organelles were vi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ogita A,Fujita K,Taniguchi M,Tanaka T

    更新日期:2006-10-01 00:00:00

  • Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium.

    abstract::The cytotoxicity and immunosuppressive activities of jaborosalactone-L and three 16 alpha-oxygenated withanolides from the leaves of Discopodium penninervium were studied. Jaborosalactone-L showed cytotoxicity only to the murine macrophage cell line, RAW 264.7, but the 16 alpha-oxygenated withanolides exhibited cytoto...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Habtemariam S

    更新日期:1997-02-01 00:00:00

  • Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and pharmacology - Part 1.

    abstract::Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractiv...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Alasbahi RH,Melzig MF

    更新日期:2010-05-01 00:00:00

  • Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines.

    abstract::During the seasons 1989-1993, Valeriana officinalis plants were investigated for their contents of essential oil, valerenic acid and derivatives, and valepotriates. Harvesting of the subterranean parts was started in August of the year in which the seeds were sown, and continued until the last week of April of the sub...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bos R,Woerdenbag HJ,van Putten FM,Hendriks H,Scheffer JJ

    更新日期:1998-03-01 00:00:00

  • Antifungal sesquiterpenes from Cedrus deodara.

    abstract::Two new sesquiterpenes, (E)-(2S,3S,6R)-atlantone-2,3-diol (1) and (E)-(2S,3S,6S)-atlantone-2,3,6-triol (2), along with two known sesquiterpenes, atlantolone (3) and (E)-α-atlantone (4), were isolated from Cedrus deodara Loud. The structures of the new compounds were elucidated on the basis of UV, IR, NMR, HR‑ESI-QTOF‑...

    journal_title:Planta medica

    pub_type: 信件


    authors: Chaudhary A,Sood S,Kaur P,Kumar N,Thakur A,Gulati A,Singh B

    更新日期:2012-01-01 00:00:00

  • The effect of genotype and cultivation method on the total salicylate yield of dark-leaved willows (Salix myrsinifolia).

    abstract::Ten clones of dark-leaved willows ( Salix myrsinifolia Salisb.) were grown for two years on two different sites, Luikonlahti and Punkaharju, using various combinations of soil cultivation, fertilization and mulch treatments, with the objective of comparing the effect of different cultivation methods on the growth and ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Heiska S,Rousi M,Turtola S,Meier B,Tirkkonen V,Julkunen-Tiitto R

    更新日期:2005-12-01 00:00:00

  • Composition and antimicrobial activity of the essential oil of Salvia ringens.

    abstract::The essential oils of Salvia ringens (samples A and B), were analyzed by means of GC and GC/MS. From the seventy-five identified constituents representing 99.82 and 99.86% of the oils, 1,8-cineole and alpha-pinene were the major components. Furthermore, sample B exhibited a very interesting antimicrobial profile after...

    journal_title:Planta medica

    pub_type: 信件


    authors: Tzakou O,Pitarokili D,Chinou IB,Harvala C

    更新日期:2001-02-01 00:00:00

  • New naphthalenyl glycosides from the roots of Juglans mandshurica.

    abstract::Three new glycosides, 1,4,8-trihydroxynaphthalene-1-O-D-glucopyranosyl-(1-->6)-beta-D- xylopyranoside (1), 1,4,8-trihydroxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)-alph a-L- arabinopyranoside (2), 1-hydroxy-4-methoxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)- alpha-L-rhamnopyranoside (3), were isolated from th...

    journal_title:Planta medica

    pub_type: 信件


    authors: Lee SW,Lee KS,Son JK

    更新日期:2000-03-01 00:00:00

  • Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation.

    abstract::We have examined the immunosuppressive effects of representative ginsenosides (Rb1, Rb2, Re and Rg1) from Panax ginseng C. A. Meyer on CD4+ and CD8+ lymphocyte proliferation. Ginsenosides differentially modulated lymphocyte proliferation induced by concanavalin A (Con A), lipopolysaccharide (LPS), phytohemaglutinin (P...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Cho JY,Kim AR,Yoo ES,Baik KU,Park MH

    更新日期:2002-06-01 00:00:00

  • A review on antimicrobial activity of mushroom (Basidiomycetes) extracts and isolated compounds.

    abstract::Despite the huge diversity of antibacterial compounds, bacterial resistance to first-choice antibiotics has been drastically increasing. Moreover, the association between multiresistant microorganisms and nosocomial infections highlight the problem, and the urgent need for solutions. Natural resources have been exploi...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Alves MJ,Ferreira IC,Dias J,Teixeira V,Martins A,Pintado M

    更新日期:2012-11-01 00:00:00

  • Isolation and Characterization of the Major Anthraquinone Pigments from Rumex abysinica.

    abstract::Emodin, chrysophanol and physcion have been shown to be the major anthraquinone pigments present in the dry roots of RUMEX ABYSINICA. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Munavu RM,Mudamba LO,Ogur JA

    更新日期:1984-02-01 00:00:00

  • Transformation of ipecac (Cephaelis ipecacuanha) with Agrobacterium rhizogenes.

    abstract::Transformed root cultures of ipecac (Cephaelis ipecacuanha A. Richard), one of the recalcitrant woody plant species for Agrobacterium-mediated transformation, were established by co-culturing of in vitro petiole segments with Agrobacterium rhizogenes ATCC 15 834. Southern blot analysis of the established roots reveale...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yoshimatsu K,Shimomura K,Yamazaki M,Saito K,Kiuchi F

    更新日期:2003-11-01 00:00:00

  • Inhibition of chemiluminescence in human PMNs by monocyclic phenolic acids and flavonoids.

    abstract::Flavonoids are metabolized in vivo to monocyclic phenolic acids. We investigated whether 18 phenolic acids of the benzoic, phenylacetic, phenylpropanoic or cinnamic series-known or potential metabolites of flavonoids-inhibit reactive oxygen species (ROS) released by human polymorphonuclear neutrophils (PMNs). Chemilum...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Limasset B,Ojasoo T,le Doucen C,Doré JC

    更新日期:1999-02-01 00:00:00

  • Phthalides in the essential oil from roots of Levisticum officinale.

    abstract::The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustil...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Gijbels MJ,Scheffer JJ,Baerheim Svendsen A

    更新日期:1982-04-01 00:00:00

  • Non-cytotoxic inhibition of macrophage eicosanoid biosynthesis and effects on leukocyte functions and reactive oxygen species of two novel anti-inflammatory plant diterpenoids.

    abstract::Two diterpenoids were prepared from hexane anti-inflammatory extracts of the Spanish herb Sideritis javalambrensis: ent-13-epi-12 alpha-acetoxymanoyl oxide (= "manoyl oxide F1") and ent-8 alpha-hydroxy-labda-13(16), 14-diene (= "labdane F2"). They were evaluated for possible anti-inflammatory actions in vitro in the c...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: de las Heras B,Hoult JR

    更新日期:1994-12-01 00:00:00