Taxol and related compounds in Korean native yews (Taxus cuspidata).


:The concentrations of taxol and related compounds in the bark and needles of Taxus cuspidata grown on Mt. Jiri, Mt. Sobaek, and Cheju Island, and T. cuspidata var. latifolia on Ullung Island in Korea were determined by high performance liquid chromatography (HPLC). The taxane content significantly varied with the location and plant part. The taxol content in the bark of native yews from Mt. Jiri and Mt. Sobaek was high when compared to that reported for Pacific yew (T. brevifolia), whereas bark from trees on Cheju and Ullung islands contained a much lower level. Surprisingly, the needles from Cheju and Ullung islands contained a much higher level of taxol (0.022% and 0.0173%, respectively) than those of intermountain locations (0.0058% to 0.0085%), on the basis of dry weight. The bark and needles of T. cuspidata var. latifolia on Ullung Island also contained relatively high concentrations of 10-deacetylbaccatin III, 0.0497% and 0.0545%, respectively, and indicated that environmental factors may affect the quantity. Taxol in the needles was confirmed by electrospray mass spectrometry. These results suggest that foliage from yew trees growing in their natural habitats on Cheju and Ullung islands may provide a renewable source for taxol.


Planta Med


Planta medica


Choi MS,Kwak SS,Liu JR,Park YG,Lee MK,An NH




Has Abstract


1995-06-01 00:00:00












  • Chemical and pharmacological investigation of the stem bark of Synadenium grantii.

    abstract::Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, su...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Munhoz AC,Minozzo BR,Cruz LS,Oliveira TL,Machado WM,Pereira AV,Fernandes D,Manente FA,Vellosa JC,Nepel A,Barison A,Beltrame FL

    更新日期:2014-04-01 00:00:00

  • Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa peregrina.

    abstract::O-Methyl (1), O-ethyl (2), and O-butyl (3) 4-[(α-L-rhamnosyloxy) benzyl] thiocarbamate (E), along with 4-(α-L-rhamnosyloxy) benzyl isothiocyanate (4) have been isolated from the aerial parts of Moringa peregrina. The compounds were tested for in vitro activity against Trypanosoma brucei rhodesiense and cytotoxicity in...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ayyari M,Salehi P,Ebrahimi SN,Zimmermann S,Portmann L,Krauth-Siegel RL,Kaiser M,Brun R,Rezadoost H,Rezazadeh S,Hamburger M

    更新日期:2014-01-01 00:00:00

  • Anti HSV-1 flavonoid derivatives tethered with houttuynin from Houttuynia cordata.

    abstract::This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of ...

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    pub_type: 杂志文章


    authors: Chen SD,Li T,Gao H,Zhu QC,Lu CJ,Wu HL,Peng T,Yao XS

    更新日期:2013-12-01 00:00:00

  • Plants: a source for new antimycobacterial drugs.

    abstract::Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...

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    pub_type: 杂志文章,评审


    authors: Santhosh RS,Suriyanarayanan B

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    abstract::The activity-guided fractionation of the hydroalcoholic extract of trunk bark of Cedrelopsis grevei led to the isolation of five coumarins, norbraylin (1), methyl-O-cedrelopsin (2), cedrecoumarin A (3), scoparone (4) and braylin (5) as a part of the constituents responsible for the vasorelaxing activity observed for t...

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    pub_type: 信件


    authors: Rakotoarison O,Rabenau I,Lobstein A,Um BH,Schott C,Anton R,Randriantsoa A,Andriantsitohaina R

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  • Protective Effects of the Total Coumarin Fraction of Urtica dentata on Experimental Diabetic Nephropathy In Vitro and In Vivo.

    abstract::We previously reported that total coumarins, the major active components of Urtica dentata Hand, exhibited substantial protection against the development of autoimmune diabetes. Diabetic nephropathy is one of the most serious complications of diabetes and is closely correlated with end-stage renal disease. We used the...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Cao H,Ji Y,Li W,Liu Y,Fu R,Xiang M

    更新日期:2015-10-01 00:00:00

  • Two new flavonol glycosides and a metabolite profile of Bryophyllum pinnatum, a phytotherapeutic used in obstetrics and gynaecology.

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    pub_type: 杂志文章


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    更新日期:2013-11-01 00:00:00

  • Endothelium-dependent vasodilator effect of extract prepared from the roots of Paeonia lactiflora on isolated rat aorta.

    abstract::Paeoniae Radix (the roots of Paeonia lactiflora Pallas) is a crude drug that is used in Asia and Europe to improve blood flow. We studied its vasodilator effect and mechanisms of action in vitro. The extract from Paeoniae Radix (PRE) relaxed prostaglandin F2a-precontracted aortic ring preparations of isolated rat aort...

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    authors: Goto H,Shimada Y,Akechi Y,Kohta K,Hattori M,Terasawa K

    更新日期:1996-10-01 00:00:00

  • New lignans and cytotoxic constituents from Wikstroemia lanceolata.

    abstract::Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known se...

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    authors: Lin RW,Tsai IL,Duh CY,Lee KH,Chen IS

    更新日期:2004-03-01 00:00:00

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    journal_title:Planta medica

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    authors: Habtemariam S,Dagne E

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    journal_title:Planta medica

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    authors: Ogita A,Fujita K,Taniguchi M,Tanaka T

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  • Inhibitory activities of lichen-derived compounds against methicillin- and multidrug-resistant Staphylococcus aureus.

    abstract::The inhibitory effects of selected phenolic lichen substances were tested against a panel of methicillin- and multidrug-resistant Staphylococcus aureus. Depsidones with long alkyl chains on both of the aromatic rings were consistently active against the strains tested, comparable to or better than the level of clinica...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kokubun T,Shiu WK,Gibbons S

    更新日期:2007-02-01 00:00:00

  • Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages.

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    journal_title:Planta medica

    pub_type: 信件


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  • Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and pharmacology - Part 1.

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    authors: Bourgeade-Delmas S,André-Barrès C,Lucas J,Trinel M,Castillo Pareja D,Jullian V

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  • Medicinal Plants from Papua New Guinea: Graniline-Esters and Germacranolides from Blumea arfakiana.

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    pub_type: 杂志文章


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  • [Germacranolides, Guaianolides, and Xanthanolides from the Flowers of Arnica mollis and an X-Ray Structure Analysis of Baileyin Acetate].

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  • A New Limonoid, Amoorinin, from the Stem Bark of Amoora rohituka.

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    pub_type: 杂志文章


    authors: Agnihotri VK,Srivastava SD,Srivastava SK

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    pub_type: 杂志文章


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    更新日期:2013-10-01 00:00:00

  • Antiulcer action of Styrax camporum and Caesalpinia ferrea in rats. '.

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    journal_title:Planta medica

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  • Acridone Alkaloids from Cell Suspension Cultures of Thamnosma montana.

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    pub_type: 杂志文章


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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Classen B,Blaschek W

    更新日期:2002-03-01 00:00:00

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    journal_title:Planta medica

    pub_type: 信件


    authors: Dharmaratne HR,Tan GT,Marasinghe GP,Pezzuto JM

    更新日期:2002-01-01 00:00:00

  • Two New Anthraquinones from the Seeds of Peganum harmala.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pitre S,Srivastava SK

    更新日期:1987-02-01 00:00:00

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    journal_title:Planta medica

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    authors: Chiou WF,Lee WS,Yeh PH

    更新日期:2006-11-01 00:00:00

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Visen PK,Shukla B,Patnaik GK,Dhawan BN

    更新日期:1993-02-01 00:00:00

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    abstract::This in vitro study aimed to determine the effects of a Panax ginseng extract on aristolochic acid-mediated toxicity in HK-2 cells. A methanolic extract of ginseng (50 µg/mL) was able to reduce cell survival after treatment with 50 µM aristolochic acid for 24, 48, and 72 h, as evidenced by a resazurin reduction assay....

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bunel V,Antoine MH,Nortier J,Duez P,Stévigny C

    更新日期:2015-03-01 00:00:00