Abstract:
:Pure compounds were isolated from plant extracts with antimalarial activity. The extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Zanthoxylum gilletii (De Wild) Waterm. (Rutaceae), and the rootbark of Margaritaria discoidea (Baill.) Webster (Euphorbiaceae). The most active compounds included (IC50 within brackets): alpha-cyperone (1) (5.5 micrograms/ml), N-isobutyldeca-2,4-dienamide (2) (5.4 micrograms/ml), and securinine (3) (5.4 micrograms/ml). A mixture of autoxidation products of beta-selinene was found to be the most active antimalarial substances obtained from C. rotundus (5.6 micrograms/ml.
journal_name
Planta Medjournal_title
Planta medicaauthors
Weenen H,Nkunya MH,Bray DH,Mwasumbi LB,Kinabo LS,Kilimali VA,Wijnberg JBdoi
10.1055/s-2006-960985subject
Has Abstractpub_date
1990-08-01 00:00:00pages
371-3issue
4eissn
0032-0943issn
1439-0221journal_volume
56pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::The fruits of OSTEOPHLOEUM PLATYSPERMUM (Myristicaceae) contain sitosterol, eperu-8(20),13-dien-3alpha,15-diol, glyceryl laurodimyristate, glyceryl 1,3-lauromyristate and five neolignans: dihydroguaiaretic acid, hydroxyotobain, hydroxyoxootobain, guaiacin and otobaphenol. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969620
更新日期:1984-02-01 00:00:00
abstract::A new strain of Claviceps was isolated from a blokked mutant of Claviceps purpurea. This strain accumulates substantial amounts of clavine alkaloids (2 g/l). The alkaloid fraction is composed of chanoclavine-I ( approximately 10%) and a mixture of agroclavine/elymoclavine (90%). Most suitable for alkaloid production i...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971231
更新日期:1982-05-01 00:00:00
abstract::Geniposide, a main iridoid glucoside component of gardenia fruit, has been shown to possess anti-inflammatory activity. However, its potential use for acute lung injury (ALI) has not yet been studied. The aim of this study was to evaluate the anti-inflammatory properties of geniposide using a mouse ALI model. ALI was ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298212
更新日期:2012-04-01 00:00:00
abstract::From the rhizomes of HYPOXIS OBTUSA two monoglucosides having the same aglycone as hypoxoside, 1-(3',4'- dihydroxyphenyl)-5-(3'',4''-dihydroxyphenyl)-1-pen-ten-4-yne, have been obtained. By methylation followed by hydrogenation they have been transformed into the same compound, 1-(3'-methoxy-4'- O-beta- D-glucopyranos...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962019
更新日期:1989-06-01 00:00:00
abstract::Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the meth...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-990249
更新日期:2007-11-01 00:00:00
abstract::Treatment of 28-hydroxyolean-12-enes with N-bromosuccinimide (NBS) in acetonitrile at room temperature afforded 12 alpha-bromooleanan-13beta, 28-epoxides in high yield. This reaction resulted in the formation of olean-9 (11), 12-diene-18alpha, 29-epoxides from 29-hydroxy isomers but recovered only starting materials f...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969575
更新日期:1985-12-01 00:00:00
abstract::The analysis of the volatile compounds in the essential oil of SOLIDAGO CANADENSISL. sensu lato (Compositae) GC and GC-MS demonstrated the presence of at least 36 compounds, 18 of which were identified. The Major comonenets are gamma (2)- and delta-cadinenes. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960930
更新日期:1990-04-01 00:00:00
abstract::YANG XIN is a traditional Chinese medicine formulation used for nervous fatigue and consists of a proprietary blend of concentrated extracts from 18 plant ingredients. The 18 constituent plant ingredients, YANG XIN capsules, and formulations 2014-005_1 A and 1B were extracted by consecutive 24-hour macerations with di...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106170
更新日期:2016-08-01 00:00:00
abstract::Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-981595
更新日期:2007-09-01 00:00:00
abstract::The aim of the present study was to investigate the antistress potential of LABISIA PUMILA aqueous extract (LPPM/A003) using a battery of tests widely employed in different stressful situations. Pretreatment of experimental animals with LPPM/A003 caused an increase in the swimming endurance and hypoxia time and also s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1240953
更新日期:2010-10-01 00:00:00
abstract::From roots of Rubia cordifolia L. four anthraquinones are isolated: 1-hydroxy 2-methoxy anthraquinone; 1,4-dihydroxy 2-methyl 5-methoxy anthraquinone or 1,4-dihydroxy 2-methyl 8-methoxy anthraquinone; 1,3-dimethoxy 2-carboxy anthraquinone and rubiadin. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971524
更新日期:1981-12-01 00:00:00
abstract::Arctigenin is a phenylpropanoid dibenzylbutyrolactone lignan compound possessing antitumor, anti-inflammatory, anti-influenza, antioxidant, antibacterial, and hypoglycaemic activities. Our previous study demonstrated that arctigenin exerts neuroprotective effects both in vitro and in vivo in a Parkinson's disease mode...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-107471
更新日期:2017-01-01 00:00:00
abstract::Both borneol and menthol are bioactive substances derived from Chinese herbal medicines. In order to understand the pharmacokinetics of borneol and menthol in Qingyan drop pills, a rapid, sensitive, and simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the simultaneous dete...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1270998
更新日期:2011-09-01 00:00:00
abstract::Rice bran, a by-product of brown rice milling, is a rich source of dietary fiber and protein, and its usage as a functional food is expected to increase. In this study, immunomodulatory effects of glycoprotein obtained from rice bran were studied in normal mice and mouse models of cyclophosphamide-induced immunosuppre...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101944
更新日期:2016-05-01 00:00:00
abstract::The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed. Xanthoxyline (30 to 300 microM) inhibited contractions of t...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960878
更新日期:1990-02-01 00:00:00
abstract::The chloroform extract of the stems of Encelia ventorum yielded a new benzopyranbenzofuran dimer. The structure was assigned from (1)H-NMR and MS data as 4[2-(5-acetyl-6-hydroxybenzofuranyl)]-2-[6(7-methoxy-2, 2-dimethylbenzo-1 -pyranyl)]-pentan-2-ol. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969992
更新日期:1983-04-01 00:00:00
abstract::The aim of this study was to investigate the effect of demethylbellidifolin (DMB), a major xanthone compound of Swertia davidi franch, on nitroglycerin (NTG) tolerance. In the in vivo portion of the study, pretreatment of Sprague-Dawley rats with NTG (10 mg/kg) for 8 days caused tolerance to the depressor effect of NT...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1185774
更新日期:2009-11-01 00:00:00
abstract::From the leaves of DIGITALIS LANATA Ehrh. two new Cardenolides have been found and structurally elucidated as Digoxigenin-3-O-beta- D-digitoxosido-beta- D-digitoxosido-beta- D-xyloside bei TLC and spectroscopic methods. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969697
更新日期:1984-06-01 00:00:00
abstract::A new steroidal saponin, timosaponin F, along with six known compounds was isolated from the rhizomes of Anemarrhena asphodeloides Bge. On the basis of chemical and spectroscopic evidence, the structure of timosaponin F was elucidated as (5beta, 25 S):-spirostan-3beta,15alpha,23alpha-triol-3-O-beta- glucopyranosyl-(1-...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960842
更新日期:1999-10-01 00:00:00
abstract::A microdilution technique was developed for the assessment of in vitro cytotoxicity against KB cells derived from a human epidermoid carcinoma of the nasopharynx. The test was used to determine the cytotoxicity of a series of quassinoids, isolated from Brucea javanica, and which have previously been shown to demonstra...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960020
更新日期:1991-02-01 00:00:00
abstract::Annona purpurea has been traditionally used by indigenous and socioeconomically disadvantaged people to treat infectious and parasitic diseases, including amoebiasis. The goal of this study was to assess the effect of a crude methanolic extract, an alkaloid extract, and aporphine alkaloids from leaves of A. purpurea o...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1111-9566
更新日期:2020-04-01 00:00:00
abstract::Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. Recently, rutaecarpine has been characterized to have an anti-inflammatory activity through cyclooxygenase-2 inhibition. In the present studies, the effects of rutaecarpine on liver cytochrome P450 s (P450s) and P450 s involved...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827207
更新日期:2004-08-01 00:00:00
abstract::Orosunol and 8-demethylorosunol, two new 1-aryl-2,3-naphthalide lignans, have been isolated from Justicia flava root. Structures IV and V respectively have been proposed for them by spectral (UV, IR, PMR, (13)C NMR, and MS) and chemical evidence. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971427
更新日期:1982-03-01 00:00:00
abstract::As a result of the reinvestigation of the alkaloid content of CORYDALIS BULBOSA (L.) DC. (Papaveraceae), growing in Bulgaria, a new 8,11-dioxoaporphine alkaloid, named bulbodione, together with dihydrosanguinarine, dehydroglaucine, (+/-)-sinactine, glaucinone and bicucullinine were isolated. These six alkaloids had no...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969652
更新日期:1984-04-01 00:00:00
abstract::The accumulation of two dihydrofuroquinoline alkaloids has been studied in seventeen strains of Choisya ternata (Rutaceae) initiated from the same tree. The contents of platydesminium and balfourodinium vary in heavy proportions. The effect of some factors (age of the culture, NAA or glucose concentrations of the medi...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971221
更新日期:1982-12-01 00:00:00
abstract::Ent-11alpha-hydroxy-16-kauren-15-one (1) induced apoptosis in a human leukemia cell line (HL-60 cells), however, the apoptosis-inducing properties of 1 and its related compounds remain to be proved. We examined the involvement of caspases, a family of cysteine aspartic proteases, which play a central role in induction...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2003-38888
更新日期:2003-04-01 00:00:00
abstract::Six diarylheptanoids were isolated from the rhizome of Alpinia officinarum (Zingiberaceae) as inhibitors of nitric oxide (NO) production in the lipopolysaccharide-activated macrophage cell line RAW 264.7. A double bond at C-4 of the linker between two aromatic rings was found to be essential for activity. Furthermore,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-873176
更新日期:2006-01-01 00:00:00
abstract::Interleukin (IL)-5 plays an important role in the progression of allergic inflammation. Here, we have isolated 21alpha-methylmelianodiol and 21beta-methylmelianodiol from Poncirus trifoliata (L.) Raf., a plant of the Rutaceae family, as the inhibitors of IL-5-dependent growth of Y16 pro-B cells by bioassay-guided frac...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1034329
更新日期:2008-03-01 00:00:00
abstract::DNA technology provides a powerful tool to complement chemical analyses for authentication of Chinese medicinal plants and to ensure that herbal materials are not contaminated with ineffective or potentially harmful substitutes or adulterants. In the last two decades molecular biotechnology has provided sophisticated ...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1250519
更新日期:2010-12-01 00:00:00
abstract::Reduced estrogen levels occurring during menopause in woman are accompanied by a variety of disorders, e. g., hot flushes, depressions, osteoporosis, increase of body weight, and reduced movement drive. In this study we investigated the combined effects of physical activity, estradiol substitution, and a phytoestrogen...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931579
更新日期:2006-05-01 00:00:00