Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.


:Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the methanol extract of Mori Cortex Radicis was selected. Fractionation of the extract by monitoring antiviral activity with a replicon cell-based assay resulted in the isolation of five compounds, mulberroside C ( 1), moracin P ( 2), moracin O ( 3), moracin M ( 4) and mulberrofuran K ( 5) from the ethyl acetate-soluble fraction. Compounds 1 approximately 4 showed significant inhibitory activities. Compounds 2 and 3 showed potent inhibitory activity (IC (50) 35.6 microM, 80.8 microM, respectively) in the replicon cell assay, which was confirmed by NS3 helicase inhibitory activity (IC (50) 42.9 microM, 27.0 microM, respectively).


Planta Med


Planta medica


Lee HY,Yum JH,Rho YK,Oh SJ,Choi HS,Chang HB,Choi DH,Leem MJ,Choi EJ,Ryu JM,Hwang SB




Has Abstract


2007-11-01 00:00:00












  • Differentiation of the traditional Chinese medicinal plants Euphorbia humifusa and E. maculata from adulterants by TaqMan real-time polymerase chain reaction.

    abstract::DNA sequence analysis of the rDNA internal transcribed spacer 1 (ITS1) and TaqMan real-time polymerase chain reaction were exploited for their applications in the differentiation of the traditional chinese medicinal plants euphorbia humifusa and e. maculata from three related adulterants e. hypericifolia, E. atoto and...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xue HG,Wang H,Li DZ,Xue CY,Wang QZ

    更新日期:2008-02-01 00:00:00

  • LC-MS- and NMR-Guided Isolation of Monoterpene Dimers from Cultivated Thymus vulgaris Varico 3 Hybrid and Their Antityrosinase Activity.

    abstract::Targeted isolation based on a combination of NMR and HPLC-PDA-MS of a dichloromethane extract of Thymus vulgaris Varico 3 aerial parts afforded one new p-cymene dimer, 6,3',4'-trihydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1: ), together with two known p-cymene derivatives (2: and 3: ), as well as five known compo...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Stefanis I,Hadjipavlou-Litina D,Bilia AR,Karioti A

    更新日期:2019-08-01 00:00:00

  • An arabinogalactan-protein from cell culture of Malva sylvestris.

    abstract::An arabinogalactan-protein (AGP) from suspension culture medium of Malva sylvestris was isolated by precipitation with beta-glucosyl Yariv reagent, followed by gel-permeation chromatography. It revealed characteristic features of AGPs: a high amount of polysaccharide with a ratio of galactose to arabinose of 1.9 : 1, ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Classen B,Blaschek W

    更新日期:2002-03-01 00:00:00

  • Distinguishing Vaccinium species by chemical fingerprinting based on NMR spectra, validated with spectra collected in different laboratories.

    abstract::A method was developed to distinguish Vaccinium species based on leaf extracts using nuclear magnetic resonance spectroscopy. Reference spectra were measured on leaf extracts from several species, including lowbush blueberry (Vaccinium angustifolium), oval leaf huckleberry (Vaccinium ovalifolium), and cranberry (Vacci...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Markus MA,Ferrier J,Luchsinger SM,Yuk J,Cuerrier A,Balick MJ,Hicks JM,Killday KB,Kirby CW,Berrue F,Kerr RG,Knagge K,Gödecke T,Ramirez BE,Lankin DC,Pauli GF,Burton I,Karakach TK,Arnason JT,Colson KL

    更新日期:2014-06-01 00:00:00

  • Formation of Digitalis lanata Clone Lines by Shoot Tip Culture.

    abstract::Propagation of DIGITALIS LANATA by shoot tip culture made possible (a) the rapid multiplication of elite plants with the formation of plant clones and (b) the long-term cultivation of these plants which under normal growth conditions would die at the end of the second vegetation period. Optimum conditions were establi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Diettrich B,Mertinat H,Luckner M

    更新日期:1990-02-01 00:00:00

  • Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea.

    abstract::Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Rojas A,Bah M,Rojas JI,Gutiérrez DM

    更新日期:2000-12-01 00:00:00

  • Effects of baicalin on airway remodeling in asthmatic mice.

    abstract::Airway remodeling is an important characteristic of asthma, linking inflammation with airway hyperresponsiveness. Baicalin, a major active component, was isolated from Radix Scutellariae. Many studies show that baicalin has anti-inflammatory, anti-bacterial, and anti-allergic effects. Here we investigate the influence...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sun J,Li L,Wu J,Liu B,Gong W,Lv Y,Luo Q,Duan X,Dong J

    更新日期:2013-03-01 00:00:00

  • Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri.

    abstract::Sangre de Grado extract used by Peruvian natives as a cicatrizant agent, was collected from trees of the species Croton lechleri growing in the Peruvian jungle. The Sangre de Grado was found to contain one alkaloid identified as taspine and which was shown to be the active cicatrizant principle by an in vivo test in m...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Vaisberg AJ,Milla M,Planas MC,Cordova JL,de Agusti ER,Ferreyra R,Mustiga MC,Carlin L,Hammond GB

    更新日期:1989-04-01 00:00:00

  • Somatic embryogenesis and rhizogenesis of tissue cultures of two genotypes of Papaver somniferum: relationships to alkaloids production.

    abstract::PAPAVER SOMNIFERUM L. tissue cultures, issued from various explants (cotyledons, hypocotyls, roots) derived from plantlets belonging to two genotypes, were established on LS solid medium containing growth regulators (NAA, Kin) in various combinations. Hypocotyls and roots were found to be interesting explants to obtai...

    journal_title:Planta medica

    pub_type: 信件


    authors: Laurain-Mattar D,Gillet-Manceau F,Buchon L,Nabha S,Fliniaux MA,Jacquin-Bubreuil A

    更新日期:1999-03-01 00:00:00

  • New Clerodane Derivatives from Teucrium scordium.

    abstract::A reinvestigation of the aerial parts of TEUCRIUM SCORDIUM afforded in addition to several known diterpenes five new clerodane derivatives, all closely related to teucrin. The structures and the stereochemistry were elucidated by high resolution (1)H-NMR spectroscopy. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jakupovic J,Baruah RN,Bohlmann F,Quack W

    更新日期:1985-08-01 00:00:00

  • Alkaloids from Corydalis marschalliana.

    abstract::The known alkaloids (+/-)-stylopine, (+/-)-sinactine, protopine, (+)-bulbocapnine, (-)-domesticine, (+)-corydine and (+)-isoboldine were found in the mixture of alkaloids from Corydalis marschalliana (Papaveraceae), growing in Bulgaria. The alkaloids dehydronantenine, (+)-nantenine and oxonantenine were isolated for t...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kiryakov HG,Iskrenova E,Kuzmanov B,Evstatieva L

    更新日期:1981-03-01 00:00:00

  • New flavonoids from the aerial parts of Aconitum chiisanense.

    abstract::The studies were carried out to evaluate the constituents in the aerial part of Aconitum chiisanense (Ranunculaceae). From the butanol fraction of the methanol extract, kaempferol 3- O-beta-glucopyranoside-7- O-(6-trans-caffeoyl)-beta-glucopyranosyl-(1-->2)-alpha-rhamnopyranoside (I), quercetin 3- O-beta-glucopyranosi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jeong HJ,Whang WK,Kim IH

    更新日期:1997-08-01 00:00:00

  • Antibacterial activity of calozeyloxanthone isolated from Calophyllum species against vancomycin-resistant Enterococci (VRE) and synergism with antibiotics.

    abstract::Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synerg...

    journal_title:Planta medica

    pub_type: 信件


    authors: Sakagami Y,Kajimura K,Wijesinghe WM,Dharmaratne HR

    更新日期:2002-06-01 00:00:00

  • Hyphenated NMR methods in natural products research, part 1: direct hyphenation.

    abstract::This review describes the current status of the development of techniques combining liquid chromatography and nuclear magnetic resonance and their use in the context of natural products. HPLC-NMR methods have a rapidly growing impact on natural products research by enabling structure determination of natural products ...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Jaroszewski JW

    更新日期:2005-08-01 00:00:00

  • Oligostilbenes from the roots of Vitis thunbergii.

    abstract::Reinvestigating the constituents of the roots of Vitis thunbergii Sieb. & Zucc. led to the isolation of three new resveratrol derivatives, vitisinols E-G (1-3), together with 14 known compounds. The structures of compounds 1-3 were established by application of spectroscopic analyses (NMR, MS, UV, and IR). ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chiou WF,Shen CC,Chen CC,Lin CH,Huang YL

    更新日期:2009-06-01 00:00:00

  • Further Triterpenoids of Musanga cecropioides: The Structure of Cecropic Acid.

    abstract::Six pentacyclic triterpenic acid methyl esters have been isolated from the methylated ethyl acetate extract of the trunk wood of MUSANGA CECROPIOIDES, as well as a triterpene saponin of the same group. One of them, cecropic acid methyl ester, is new. The structures of these compounds have been established from interpr...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lontsi D,Sondengam BL,Ayafor JF,Tsoupras MG,Tabacchi R

    更新日期:1990-06-01 00:00:00

  • Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells.

    abstract::Baicalein, berberine, curcumin and hesperidin are the major components derived from Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata, respectively. These plants have been used for the treatment of diverse chronic inflammatory diseases including respiratory disease in oriental medicine an...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee CJ,Lee JH,Seok JH,Hur GM,Park YC,Seol IC,Kim YH

    更新日期:2003-06-01 00:00:00

  • Inhibitory effects of bisbenzylisoquinoline alkaloids on induction of proinflammatory cytokines, interleukin-1 and tumor necrosis factor-alpha.

    abstract::Bisbenzylisoquinoline alkaloids are known to affect immune responses as well as inflammatory responses, and have been used for the treatment of inflammatory symptoms in China. This study is aimed at elucidating the inhibitory effects of two alkaloids, fangchinoline and isotetrandrine, on the induction of the proinflam...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Onai N,Tsunokawa Y,Suda M,Watanabe N,Nakamura K,Sugimoto Y,Kobayashi Y

    更新日期:1995-12-01 00:00:00

  • A preadipocyte differentiation assay as a method for screening potential anti-type II diabetes drugs from herbal extracts.

    abstract::A cell-based method for screening drug candidates from herbal extracts that have possible anti-type II diabetic effects was established. The differentiation of preadipocytes into adipocytes was used as a sensitive primary indicator of a drug's potential effect on type II diabetes. We established a quantitative method ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xu ME,Xiao SZ,Sun YH,Ou-yang Y,Guan C,Zheng XX

    更新日期:2006-01-01 00:00:00

  • Bioactive polyacetylenes from Bidens pilosa.

    abstract::From the methanolic extract of the whole plants of Bidens pilosa the new beta-D-glucopyranosyloxy-3-hydroxy-6(E)-tetradecen-8, 10,12-triyne besides a known polyine has been isolated and identified mainly by IR and NMR methods. The new compound showed overgrowing action against normal and transformed human cell lines i...

    journal_title:Planta medica

    pub_type: 信件


    authors: Alvarez L,Marquina S,Villarreal ML,Alonso D,Aranda E,Delgado G

    更新日期:1996-08-01 00:00:00

  • The Constitution and Configuration of Isocaryophyllen-13-al.

    abstract::The aerial parts of CUNILA SPICATA Benth., a Brasilian Lamiaceae, afforded a sesquiterpene-aldehyde named isocaryophyllen-13-al (beta-betulenal) ( 1). The constitution and configuration of this compound were established by high field NMR-techniques for the first time. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Manns D,Hartmann R

    更新日期:1992-10-01 00:00:00

  • Anti-inflammatory isoflavonoids from the stems of Derris scandens.

    abstract::Fractionation of the aqueous extract of Derris scandens stems extract using tests for eicosanoid inhibition resulted in the isolation of three isoflavonoids, genistein, its 7- O-alpha-rhamno(1-->6)-beta-glucosyl glycoside, a new compound, and two known isoprenyl derivatives 3'-gamma,gamma-dimethylallylweighteone and s...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Laupattarakasem P,Houghton PJ,Hoult JR

    更新日期:2004-06-01 00:00:00

  • From ill-defined extracts to the immunomodulatory lectin: will there be a reason for oncological application of mistletoe?

    abstract::There is an obvious discrepancy between the popularity of mistletoe extracts and their classification as a non-conventional treatment modality with unproven efficacy in oncology. The commercial preparations suffer from several major drawbacks: lack of precise declarations for the molecular characteristics and the conc...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Gabius HJ,Gabius S,Joshi SS,Koch B,Schroeder M,Manzke WM,Westerhausen M

    更新日期:1994-02-01 00:00:00

  • Transformed cell suspension culture of Galphimia glauca producing sedative nor-friedelanes.

    abstract::The Mexican species GALPHIMIA GLAUCA (Cav.) Kuntze (Malphigiaceae) synthesises a family of sedative and anxiolytic nor-secofriedelanes, designated as galphimines. These active principles accumulate at low concentration in the aerial parts of plants from wild populations. Transformed calluses and cell suspension cultur...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ortíz A,Cardoso-Taketa A,Monroy MR,Arellano J,Hernández G,Villarreal ML

    更新日期:2010-03-01 00:00:00

  • Light-mediated antifungal activity of Echinacea extracts.

    abstract::This study demonstrated that plant extracts containing acetylenic isobutylamides and polyacetylenes, previously reported as occurring in Echinacea, have phototoxic antimicrobial activity against fungi, including clinically relevant pathogenic fungi. Results show that hexane extracts of Echinacea variably inhibit growt...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Binns SE,Purgina B,Bergeron C,Smith ML,Ball L,Baum BR,Arnason JT

    更新日期:2000-04-01 00:00:00

  • Effects of Sideritis scardica Extract on Glucose Tolerance, Triglyceride Levels and Markers of Oxidative Stress in Ovariectomized Rats.

    abstract::Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an incre...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jeremic I,Petricevic S,Tadic V,Petrovic D,Tosic J,Stanojevic Z,Petronijevic M,Vidicevic S,Trajkovic V,Isakovic A

    更新日期:2019-04-01 00:00:00

  • 11-deoxyalisol C and alisol D: new protostane-type triterpenoids from Alisma plantago-aquatica.

    abstract::New protostane-type triterpenes, 11-deoxyalisol C and alisol D, have been isolated from the rhizomes of ALISMA PLANTAGO-AQUATICA, and their structures have been elucidated on the basis of spectral and chemical data. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Fukuyama Y,Pei-Wu G,Rei W,Yamada T,Nakagawa K

    更新日期:1988-10-01 00:00:00

  • Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis.

    abstract::Scutellariae Radix (SR), the root of Scutellaria baicalensis (Labiatae), is widely used in clinical Chinese medicine. In order to investigate the effect of SR on the absorption and disposition of cyclosporine, rats were administered with cyclosporine orally (in the form of the microemulsion Neoral and intravenously wi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lai MY,Hsiu SL,Hou YC,Tsai SY,Chao PD

    更新日期:2004-02-01 00:00:00

  • Antiviral Activity of a Arisaema Tortuosum Leaf Extract and Some of its Constituents against Herpes Simplex Virus Type 2.

    abstract::Infections caused by HSV-2 are a public health concern worldwide, and there is still a great demand for the discovery of novel anti-herpes virus agents effective against strains resistant to current antiviral agents. In this context, medicinal plants represent an alternative source of active compounds for developing e...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Rittà M,Marengo A,Civra A,Lembo D,Cagliero C,Kant K,Lal UR,Rubiolo P,Ghosh M,Donalisio M

    更新日期:2020-03-01 00:00:00

  • Antiherpetic activities of sulfated polysaccharides from green algae.

    abstract::In order to evaluate the potency of novel antiviral drugs, 11 natural sulfated polysaccharides (SPs) from 10 green algae ( Enteromorpha compressa, Monostroma nitidum, Caulerpa brachypus, C. okamurai, C. scapelliformis, Chaetomorpha crassa, C. spiralis, Codium adhaerens, C. fragille, and C. latum) and 4 synthetic sulfa...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee JB,Hayashi K,Maeda M,Hayashi T

    更新日期:2004-09-01 00:00:00