Abstract:
:A novel hasubanalactam alkaloid, named glabradine, has been isolated from the tubers of Stephania glabra, together with three known quaternary protoberberine alkaloids, palmatine, dehydrocorydalmine and stepharanine. The structure of glabradine was assigned as 7-O-demethyl-N,O-dimethyloxostephinine, by means of rigorous spectroscopic analysis including 2 D NMR measurements. It was evaluated for antimicrobial activity against Staphylococcus aureus, S. mutans, Microsporum gypseum, M. canis and Trichophyton rubrum and displayed potent antimicrobial activity superior to those of novobiocin and erythromycin used as positive controls.
journal_name
Planta Medjournal_title
Planta medicaauthors
Semwal DK,Rawat Udoi
10.1055/s-0028-1112223subject
Has Abstractpub_date
2009-03-01 00:00:00pages
378-80issue
4eissn
0032-0943issn
1439-0221journal_volume
75pub_type
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