Antimicrobial hasubanalactam alkaloid from Stephania glabra.

Abstract:

:A novel hasubanalactam alkaloid, named glabradine, has been isolated from the tubers of Stephania glabra, together with three known quaternary protoberberine alkaloids, palmatine, dehydrocorydalmine and stepharanine. The structure of glabradine was assigned as 7-O-demethyl-N,O-dimethyloxostephinine, by means of rigorous spectroscopic analysis including 2 D NMR measurements. It was evaluated for antimicrobial activity against Staphylococcus aureus, S. mutans, Microsporum gypseum, M. canis and Trichophyton rubrum and displayed potent antimicrobial activity superior to those of novobiocin and erythromycin used as positive controls.

journal_name

Planta Med

journal_title

Planta medica

authors

Semwal DK,Rawat U

doi

10.1055/s-0028-1112223

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

378-80

issue

4

eissn

0032-0943

issn

1439-0221

journal_volume

75

pub_type

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