Abstract:
:Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1'-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4- 6, 9- 15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37R (V) IN VITRO, with MIC values of 2.5-60 µg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone ( 8), were reported for their selective cytotoxic activity against the NCI-H460 cancer cell line (IC (50) values of 2.3, 2.5 µg/mL).
journal_name
Planta Medjournal_title
Planta medicaauthors
Chang CP,Chang HS,Peng CF,Lee SJ,Chen ISdoi
10.1055/s-0030-1250094subject
Has Abstractpub_date
2011-01-01 00:00:00pages
60-5issue
1eissn
0032-0943issn
1439-0221journal_volume
77pub_type
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