Antitubercular resorcinol analogs and benzenoid C-glucoside from the roots of Ardisia cornudentata.

Abstract:

:Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1'-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4- 6, 9- 15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37R (V) IN VITRO, with MIC values of 2.5-60 µg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone ( 8), were reported for their selective cytotoxic activity against the NCI-H460 cancer cell line (IC (50) values of 2.3, 2.5 µg/mL).

journal_name

Planta Med

journal_title

Planta medica

authors

Chang CP,Chang HS,Peng CF,Lee SJ,Chen IS

doi

10.1055/s-0030-1250094

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

60-5

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

77

pub_type

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