Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta.

Abstract:

:The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were investigated. Intravenous spiramine T (0.38, 0.75, and 1.5 mg.kg-1) markedly reduced the stroke index, enhanced the recovery of EEG amplitude during reperfusion and decreased the concentrations of cortex calcium and LPO in a dose-dependent manner. However, no significant effects on water and sodium contents were observed. These results suggested that spiramine T exhibited protective effects on cerebral ischemia-reperfusion injury in gerbils, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation. This is the first report on spiramine T as a natural product with neuroprotective effects.

journal_name

Planta Med

journal_title

Planta medica

authors

Li L,Nie J,Shen Z,Wu W,Chen Z,Hao X

doi

10.1055/s-2001-11510

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

142-5

issue

2

eissn

0032-0943

issn

1439-0221

journal_volume

67

pub_type

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