Antiplatelet aggregation principles from Ephemerantha lonchophylla.

abstract：:VERATRUM CALIFORNICUM (Liliaceae) is an important monocotyledonous medicinal plant which is the only source of the anticancer compound cyclopamine. An IN VITRO culture system for somatic embryogenesis and green plant regeneration of VERATRUM CALIFORNICUM was developed. Embryogenic calli were induced from mature embryo...

journal_title：Planta medica

authors： Ma R,Ritala A,Oksman-Caldentey KM,Rischer H

更新日期：2006-10-01 00:00:00

abstract：:From the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), longicaudatine Y (6), and longicaudatine F (7). All the compounds were tested for their antim...

journal_title：Planta medica

authors： Tchinda AT,Ngono AR,Tamze V,Jonville MC,Cao M,Angenot L,Frédérich M

更新日期：2012-03-01 00:00:00

abstract：:From the fresh rhizomes of Tamus communis five phenanthrenes (1 - 5) were isolated under the guidance of cytotoxic assays in HeLa cells. The compounds were obtained from the highly active CHCl (3) fraction of the MeOH extract by using multistep chromatographic purifications, including VLC, preparative TLC, HPLC and ge...

journal_title：Planta medica

authors： Réthy B,Kovács A,Zupkó I,Forgo P,Vasas A,Falkay G,Hohmann J

更新日期：2006-06-01 00:00:00

abstract：:Owing to their high content of flavonoids and saponins, plantlets of Avena sativa L. (Poaceae) are likely to possess anti-inflammatory and immunoregulatory properties of value in the treatment of atopic dermatitis (AD). With a view to its potential use in atopic subjects at risk of developing sensitisation to dietary ...

journal_title：Planta medica

authors： Mandeau A,Aries MF,Boé JF,Brenk M,Crebassa-Trigueros V,Vaissière C,Teysseyre V,Bieber T

更新日期：2011-06-01 00:00:00

abstract：:Extracts from Pygeum africanum, Serenoa repens and Cucurbita pepo are used in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The activity of the androgen receptor (AR) is known to control growth of the prostate. Here, we examined extracts of these plants for their antiandrogenic activit...

journal_title：Planta medica

authors： Schleich S,Papaioannou M,Baniahmad A,Matusch R

更新日期：2006-07-01 00:00:00

abstract：:We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused ...

journal_title：Planta medica

authors： Anca JM,Lamela M,Calleja JM

更新日期：1993-06-01 00:00:00

abstract：:Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with t...

journal_title：Planta medica

authors： Oh H,Ko EK,Jun JY,Oh MH,Park SU,Kang KH,Lee HS,Kim YC

更新日期：2002-10-01 00:00:00

abstract：:Products derived from Noni fruit (Morinda citrifolia) have been commercialised in the USA since the 1990s and are increasingly distributed all over the world. A large number of beneficial effects have been claimed for Noni. Fruit juice of Noni has been approved as a Novel Food by the European Commission in 2003. This ...

journal_title：Planta medica

authors： Potterat O,Hamburger M

更新日期：2007-03-01 00:00:00

abstract：:Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic...

journal_title：Planta medica

authors： MacKinnon SL,Hodder M,Craft C,Simmons-Boyce J

更新日期：2007-09-01 00:00:00

abstract：:Effects of puerarin, an active principle contained in the roots of Pueraria lobata (Leguminosae), on the regulation of glucose metabolism in an insulin deficient state were investigated in cultured myoblast C 2 C 12 cells using glucose uptake as indicator. Puerarin enhanced the uptake of radioactive glucose into C 2 C...

journal_title：Planta medica

authors： Hsu HH,Chang CK,Su HC,Liu IM,Cheng JT

更新日期：2002-11-01 00:00:00

abstract：:A new activity of triterpenes and triterpenoid glycosides against phytovirus has been found. Based on the anti-TMV replication activity in vivo, 47 triterpenes and triterpenoid glycosides were screened through the leaf-disk method together with indirect ELISA. Structure-activity relationships were analyzed according t...

journal_title：Planta medica

authors： Zhang ZK,Ouyang MA,Wu ZJ,Lin QY,Xie LH

更新日期：2007-11-01 00:00:00

abstract：:Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3''-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3'-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3,11,3'-O-(3'...

journal_title：Planta medica

authors： Berkov S,Cuadrado M,Osorio E,Viladomat F,Codina C,Bastida J

更新日期：2009-10-01 00:00:00

abstract：:Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synerg...

journal_title：Planta medica

authors： Sakagami Y,Kajimura K,Wijesinghe WM,Dharmaratne HR

更新日期：2002-06-01 00:00:00

abstract：:Many anti-inflammatory agents are known to significantly enhance the terminal differentiation of some cancer cells such as leukemia cells. In this study, the effect of yomogin, a eudesmane sesquiterpene lactone isolated from Artemisia princeps with anti-inflammatory activity, was investigated in human promyelocytic le...

journal_title：Planta medica

authors： Kim SH,Kim TS

更新日期：2002-10-01 00:00:00

abstract：:The effects of four fractions, a hexane fraction, an ethyl acetate fraction, an N-butanol fraction and a water fraction, from a water extract of Herba Visci were investigated to find the fraction, in IN VITRO experiments, with the greatest ability to inhibit the formation of osteoclast-like multinucleated cells from m...

journal_title：Planta medica

authors： Yin J,Han N,Xu X,Liu Z,Zhang B,Kadota S

更新日期：2008-02-01 00:00:00

abstract：:The methanol extract of the defatted roots of Asparagus adscendens Roxb. yielded beta-sitosterol beta-D-glucoside, two new spirostanol glycosides (asparanin C and asparanin D) and two new furostanol glycosides (asparoside C and asparoside D). ...

journal_title：Planta medica

authors： Sharma SC,Chand R,Bhatti BS,Sati OP

更新日期：1982-09-01 00:00:00

abstract：:Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evalu...

journal_title：Planta medica

authors： Lee TH,Lee CK,Tsou WL,Liu SY,Kuo MT,Wen WC

更新日期：2007-10-01 00:00:00

abstract：:Three new vermistatin derivatives, 6-demethylpenisimplicissin (1), 5'-hydroxypenisimplicissin (2), and 2''-epihydroxydihydrovermistatin (3), along with five known vermistatin analogues, methoxyvermistatin (4), vermistatin (5), 6-demethylvermistatin (6), hydroxyvermistatin (7), and penisimplicissin (8), were isolated f...

journal_title：Planta medica

authors： Liu Y,Xia G,Li H,Ma L,Ding B,Lu Y,He L,Xia X,She Z

更新日期：2014-07-01 00:00:00

abstract：:Natural compounds have been the first historical source of antithrombotic compounds (heparin, vitamin K antagonists, streptokinase, urokinase); molecules extracted from plants or animals still provide some of the most original and promising approaches for the discovery of new drugs in this class. In this review, we wi...

journal_title：Planta medica

authors： Beretz A,Cazenave JP

更新日期：1991-10-01 00:00:00

abstract：:We have identified kamebakaurin as an inhibitor of NF-KB and elucidated its molecular mechanism as a specific inhibitor in the DNA-binding activity of the p50 subunit of NF-KB. Here, we describe its anti-inflammatory activity in in vitro and in vivo models. Kamebakaurin dose-dependently inhibited not only the expressi...

journal_title：Planta medica

authors： Lee JH,Choi JK,Noh MS,Hwang BY,Hong YS,Lee JJ

更新日期：2004-06-01 00:00:00

abstract：:Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available tre...

journal_title：Planta medica

authors： Mamede L,Ledoux A,Jansen O,Frédérich M

更新日期：2020-06-01 00:00:00

abstract：:A new cytotoxic cyclopenta[b]benzofuran derivative, aglaiformosanin (1) and three known cyclopenta[b]benzofuran derivatives (2 - 4) were isolated from the stem bark of Aglaia formosana. Compounds 1 - 4 exhibited potent cytotoxicity against the P-388, KB, HT-29, HL-60, and A549 cell lines. The structure of compound 1 w...

journal_title：Planta medica

authors： Wang SK,Duh CY

更新日期：2001-08-01 00:00:00

abstract：:The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level...

journal_title：Planta medica

authors： Ali AM,Mackeen MM,Hamid M,Aun QB,Zauyah Y,Azimahtol HL,Kawazu K

更新日期：1997-02-01 00:00:00

abstract：:Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapont...

journal_title：Planta medica

authors： Jo SP,Kim JK,Lim YH

更新日期：2014-08-01 00:00:00

abstract：:Geraniol dehydrogenase, the specific enzyme involved in geraniol to citral TRANS (geranial) transformation, activity was monitored in various lemongrass cultivars differing in amounts and relative percentages of citral and geraniol in their essential oils. The enzyme activity had a positive and significant association...

journal_title：Planta medica

authors： Singh-Sangwan N,Sangwan RS,Luthra R,Thakur RS

更新日期：1993-04-01 00:00:00

abstract：:New protostane-type triterpenes, 11-deoxyalisol C and alisol D, have been isolated from the rhizomes of ALISMA PLANTAGO-AQUATICA, and their structures have been elucidated on the basis of spectral and chemical data. ...

journal_title：Planta medica

authors： Fukuyama Y,Pei-Wu G,Rei W,Yamada T,Nakagawa K

更新日期：1988-10-01 00:00:00

abstract：:Endothelial dysfunction is characterised by the low bioavailability of nitric oxide with a relevant negative impact on the nitric oxide/cGMP pathway. The loss of nitric oxide/cGMP signaling may be caused by an increased arginase activity. Plant-derived substances, especially polyphenols, are compounds that have the po...

journal_title：Planta medica

authors： Minozzo BR,Fernandes D,Beltrame FL

更新日期：2018-03-01 00:00:00

abstract：:The Mexican species GALPHIMIA GLAUCA (Cav.) Kuntze (Malphigiaceae) synthesises a family of sedative and anxiolytic nor-secofriedelanes, designated as galphimines. These active principles accumulate at low concentration in the aerial parts of plants from wild populations. Transformed calluses and cell suspension cultur...

journal_title：Planta medica

authors： Ortíz A,Cardoso-Taketa A,Monroy MR,Arellano J,Hernández G,Villarreal ML

更新日期：2010-03-01 00:00:00

abstract：:The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times low...

journal_title：Planta medica

authors： Steverding D,Pemberton AJ,Royle H,Spackman RW,Rivett AJ

更新日期：2006-06-01 00:00:00

abstract：:Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of beta-hexosaminidase from ...

journal_title：Planta medica

authors： Ryu SY,Kou NY,Choi HS,Ryu H,Kim TS,Kim KM

更新日期：2001-03-01 00:00:00