A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.

Abstract:

:Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC (50) values ranged from 0.13 +/- 0.02 to 6.09 +/- 0.07 microM.

journal_name

Planta Med

journal_title

Planta medica

authors

Lee TH,Lee CK,Tsou WL,Liu SY,Kuo MT,Wen WC

doi

10.1055/s-2007-990232

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1412-5

issue

13

eissn

0032-0943

issn

1439-0221

journal_volume

73

pub_type

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