A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.


:Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC (50) values ranged from 0.13 +/- 0.02 to 6.09 +/- 0.07 microM.


Planta Med


Planta medica


Lee TH,Lee CK,Tsou WL,Liu SY,Kuo MT,Wen WC




Has Abstract


2007-10-01 00:00:00












  • Saucernetin-7 and saucernetin-8 isolated from Saururus chinensis inhibit the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells.

    abstract::In the present study, we demonstrate that saucernetin-8 ( 1) and saucernetin-7 ( 2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) production in RAW 264.7 cells. Both compounds 1 and 2, known...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Park HJ,Kim RG,Seo BR,Ha J,Ahn BT,Bok SH,Lee YS,Kim HJ,Lee KT

    更新日期:2003-10-01 00:00:00

  • Immunomodulatory Effects of Nontoxic Glycoprotein Fraction Isolated from Rice Bran.

    abstract::Rice bran, a by-product of brown rice milling, is a rich source of dietary fiber and protein, and its usage as a functional food is expected to increase. In this study, immunomodulatory effects of glycoprotein obtained from rice bran were studied in normal mice and mouse models of cyclophosphamide-induced immunosuppre...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Park HY,Yu AR,Hong HD,Kim HH,Lee KW,Choi HD

    更新日期:2016-05-01 00:00:00

  • Effects of Sideritis scardica Extract on Glucose Tolerance, Triglyceride Levels and Markers of Oxidative Stress in Ovariectomized Rats.

    abstract::Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an incre...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jeremic I,Petricevic S,Tadic V,Petrovic D,Tosic J,Stanojevic Z,Petronijevic M,Vidicevic S,Trajkovic V,Isakovic A

    更新日期:2019-04-01 00:00:00

  • Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum.

    abstract::Three new depsidones, parmosidones F - G (1 - 2), and 8'-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A - C (4 - 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive sp...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Devi AP,Duong TH,Ferron S,Beniddir MA,Dinh MH,Nguyen VK,Pham NK,Mac DH,Boustie J,Chavasiri W,Pogam PL

    更新日期:2020-11-01 00:00:00

  • Hydroxytyrosol induces vascular smooth muscle cells apoptosis through NO production and PP2A activation with subsequent inactivation of Akt.

    abstract::Olive oil has been shown to exhibit beneficial effects in the prevention of cardiovascular diseases although its molecular mechanism still remains unclear. In the present study, we investigated the effect of hydroxytyrosol (HT), a major phenolic component in olive oil and leaves from OLEA EUROPAEA L. (Oleaceae family...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zrelli H,Matsuka M,Araki M,Zarrouk M,Miyazaki H

    更新日期:2011-10-01 00:00:00

  • Sonoran propolis and some of its chemical constituents inhibit in vitro growth of Giardia lamblia trophozoites.

    abstract::Propolis is a cereus resin with a complex chemical composition that possesses a wide range of biological activities. The aim of this study was to evaluate the in vitro anti-Giardia lamblia activity of Sonoran propolis collected from three different areas of Sonoran Desert in northwestern Mexico (Caborca, Pueblo de Ala...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Alday-Provencio S,Diaz G,Rascon L,Quintero J,Alday E,Robles-Zepeda R,Garibay-Escobar A,Astiazaran H,Hernandez J,Velazquez C

    更新日期:2015-06-01 00:00:00

  • Growth inhibition and G1 cell cycle arrest mediated by 25-methoxyhispidol A, a novel triterpenoid, isolated from the fruit of Poncirus trifoliata in human hepatocellular carcinoma cells.

    abstract::Poncirus trifoliata (Rutaceae) extracts have been known to possess anti-allergic, anti-inflammatory and antiviral activities. However, other biological activities, especially, the anticancer potential of extracts of P. trifoliata or its constituents, have not been fully investigated yet. In this study, we have evaluat...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hong J,Min HY,Xu GH,Lee JG,Lee SH,Kim YS,Kang SS,Lee SK

    更新日期:2008-02-01 00:00:00

  • Eupatoriopicrin 19-O-Linolenoate and Other Constituents from Eupatorium cannabium.

    abstract::The investigation of the roots and aerial parts of EUPATORIUM CANNABIUM afforded, in addition to the sesquiterpene lactones eupatolide, eupatoriopicrin, and eucannabinolide isolated previously, eight further lactones, three of which are new. Furthermore, in addition to known compounds, a new clerodane derivative and t...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zdero C,Bohlmann F

    更新日期:1987-04-01 00:00:00

  • Inhibitory activity of phenolic glycosides from the fruits of Idesia polycarpa on lipopolysaccharide-induced nitric oxide production in BV2 microglia.

    abstract::Two new phenolic glycosides characterized as idesin salicylate (1) and 2-hydroxyphenol-1-O-beta-D-glucopyranosyl-(6-->1)- alpha-L-rhamnopyranoside (2) were isolated with four known compounds, idescarpin (3), idesin (4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester (5) and salirepin (6), from the fruits of...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kim SH,Jang YP,Sung SH,Kim YC

    更新日期:2007-02-01 00:00:00

  • Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production.

    abstract::We have isolated five furanocoumarins, byakangelicin, phellopterin, imperatorin, isoimperatorin, and oxypeucedanin methanolate, from the roots of Angelica dahurica (Umbelliferae) and prepared five semi-synthesized compounds by the partial reduction of each isolated furanocoumarin, and the effects of these compounds on...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ban HS,Lim SS,Suzuki K,Jung SH,Lee S,Lee YS,Shin KH,Ohuchi K

    更新日期:2003-05-01 00:00:00

  • Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa.

    abstract::The antimycobacterial quinolones 1-methyl-2-undecyl-4-quinolone, dihydroevocarpine and evocarpine as well as the indoloquinazoline alkaloids rutaecarpine and evodiamine - all from the Chinese medicinal herb Evodia rutaecarpa - were tested in two in vitro assays, for cytotoxicity and interaction with p-glycoprotein (p-...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Adams M,Mahringer A,Kunert O,Fricker G,Efferth T,Bauer R

    更新日期:2007-12-01 00:00:00

  • New Cardiac Glycosides from Digitalis lanata.

    abstract::From the leaves of DIGITALIS LANATA Ehrh. two new Cardenolides have been found and structurally elucidated as Digoxigenin-3-O-beta- D-digitoxosido-beta- D-digitoxosido-beta- D-xyloside bei TLC and spectroscopic methods. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Krüger D,Wichtl M

    更新日期:1984-06-01 00:00:00

  • Acetylenes from Atractylis koreana.

    abstract::A reinvestigation of the rhizomes of ATRACTYLIS KOREANA afforded in addition to 1,3-diacetoxytetradeca-6,12-diene-8,10-diyne reported previously (1) two new C (14)-polyacetylenes with an ene-diyn-ene-chromophor and one new C (14)-polyacetylene beside two known compounds with an ene-diyne-diene-chromophor. Their struct...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pachaly P,Lansing A,Neugebauer M,Sin KS

    更新日期:1990-10-01 00:00:00

  • Flavonol glycoside gallate and ferulate esters from Persicaria lapathifolia as inhibitors of superoxide production in human monocytes stimulated by unopsonized zymosan.

    abstract::Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-beta-(2"-galloyl)-glucopyranoside and quercetin 3-O-beta-(2"-galloyl)-rhamnopyranoside, and a new compound, quer...

    journal_title:Planta medica

    pub_type: 信件


    authors: Kim Y,Jang DS,Park SH,Yun J,Min BK,Min KR,Lee HK

    更新日期:2000-02-01 00:00:00

  • Leaf alkaloid contents of Tabernaemontana pachysiphon as influenced by endogenous and environmental factors in the natural habitat.

    abstract::Indole alkaloid contents were investigated in leaves of Tabernaemontana pachysiphon (Apocynaceae) trees in the natural habitat, Shimba Hills National Reserve, Kenya. The contents of the major alkaloids apparicine, tubotaiwine, tubotaiwine- N-oxide, and isovoacangine varied with site, leaf age, leaf growth form, positi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Höft M,Verpoorte R,Beck E

    更新日期:1998-03-01 00:00:00

  • [Iridoid Glucosides from Euphrasia rostkoviana].

    abstract::Eight iridoid glucosides have been isolated from Euphrasia rostkoviana by the combination of open column- and high performance liquid chromatography. The structure of a new compound, named eurostoside, and the identity of the others have been established by chemical transformations and spectral evidence of the compoun...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Salama O,Sticher O

    更新日期:1983-02-01 00:00:00

  • Analgesic, antipyretic and anti-inflammatory properties of Euphorbia hirta.

    abstract::Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedat...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lanhers MC,Fleurentin J,Dorfman P,Mortier F,Pelt JM

    更新日期:1991-06-01 00:00:00

  • A New benzopyranbenzofuran dimer from Encelia ventorum.

    abstract::The chloroform extract of the stems of Encelia ventorum yielded a new benzopyranbenzofuran dimer. The structure was assigned from (1)H-NMR and MS data as 4[2-(5-acetyl-6-hydroxybenzofuranyl)]-2-[6(7-methoxy-2, 2-dimethylbenzo-1 -pyranyl)]-pentan-2-ol. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Proksch P,Aregullin M,Rodriguez E

    更新日期:1983-04-01 00:00:00

  • Radical scavengers from the entomogenous deuteromycete Beauveria amorpha.

    abstract::The culture medium of Beauveria amorpha Hohn. exhibited strong radical scavenging properties. Activity-directed fractionation assisted by a radical scavenging assay on TLC afforded two active compounds which were identified as 6-methyl-2,4-dihydroxyphenyl 4-O-methyl-beta-D-glucopyranoside (1) and (-)-terredionol (2). ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Hu F,Schmidt K,Stoyanova S,Zengzhi L,Gräfe U,Hamburger M

    更新日期:2002-01-01 00:00:00

  • Genetic characterization and authentication of Embelia ribes using RAPD-PCR and SCAR marker.

    abstract::Embelia ribes Burm. f. (Myrsinaceae) is one of the important plants used in Indian traditional medicine. RAPD-PCR analysis was performed to obtain species-specific DNA fragments. A band of 906 bp that was specific to Embelia ribes irrespective of the geographical source was obtained using the random decamer primer OPF...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Devaiah KM,Venkatasubramanian P

    更新日期:2008-02-01 00:00:00

  • Cytochromes P450 Inhibitory Excipient-Based Self-Microemulsions for the Improved Bioavailability of Protopanaxatriol and Protopanaxadiol: Preparation and Evaluation.

    abstract::Protopanaxatriol and protopanaxadiol exhibit limited oral bioavailability due to the poor solubility and intestinal cytochromes P450-mediated metabolism. This study set out to develop a novel cytochromes P450 inhibitory excipient(s)-based self-microemulsion to encapsulate protopanaxatriol and protopanaxadiol so as to ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yang F,Zhou J,Liu C,Hu X,Pan R,Chang Q,Liu X,Liao Y

    更新日期:2017-03-01 00:00:00

  • LC-MS-Based Quality Assessment of a Traditional Chinese Medicine YANG XIN Formulation.

    abstract::YANG XIN is a traditional Chinese medicine formulation used for nervous fatigue and consists of a proprietary blend of concentrated extracts from 18 plant ingredients. The 18 constituent plant ingredients, YANG XIN capsules, and formulations 2014-005_1 A and 1B were extracted by consecutive 24-hour macerations with di...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Almalki AJ,Zaher A,Simithy J,Keller WJ,Tripp M,Calderón AI

    更新日期:2016-08-01 00:00:00

  • Bioactive coumarin derivatives from the fern Cyclosorus interruptus.

    abstract::Three new coumarin derivatives, compounds 1-3, three new furanocoumarins, compounds 4-6, and a novel dioxocane derivative, compound 7, were isolated from the fern Cyclosorus interruptus (Willd.) H. Itô. Based on spectrometric and spectroscopic analysis (FAB or El mass spectrometry as well as 1D and 2D NMR experiments)...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Quadri-Spinelli T,Heilmann J,Rali T,Sticher O

    更新日期:2000-12-01 00:00:00

  • New naphthalenyl glycosides from the roots of Juglans mandshurica.

    abstract::Three new glycosides, 1,4,8-trihydroxynaphthalene-1-O-D-glucopyranosyl-(1-->6)-beta-D- xylopyranoside (1), 1,4,8-trihydroxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)-alph a-L- arabinopyranoside (2), 1-hydroxy-4-methoxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)- alpha-L-rhamnopyranoside (3), were isolated from th...

    journal_title:Planta medica

    pub_type: 信件


    authors: Lee SW,Lee KS,Son JK

    更新日期:2000-03-01 00:00:00

  • Two major urinary metabolites of scutellarin in rats.

    abstract::Urinary metabolites of scutellarin, the main effective constituent of breviscapine, a cerebrovascular and cardiovascular drug consisting of total flavonoids of Erigeron breviscapus, were investigated in rats. Two major metabolites were isolated from the urine of rats following oral administration of scutellarin and id...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Qiu F,Xia H,Zhang T,Di X,Qu G,Yao X

    更新日期:2007-04-01 00:00:00

  • A Review of the Toxicity of Compounds Found in Herbal Dietary Supplements.

    abstract::Use of herbal dietary supplements by the public is common and has been happening for centuries. In the United States, the Food and Drug Administration has a limited scope of regulation over marketed herbal dietary supplements, which may contain toxic botanical compounds that pose a public health risk. While the Food a...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Hudson A,Lopez E,Almalki AJ,Roe AL,Calderón AI

    更新日期:2018-07-01 00:00:00

  • Characterization of the Anticoagulative Constituents of Angelicae Sinensis Radix and Their Metabolites in Rats by HPLC-DAD-ESI-IT-TOF-MSn.

    abstract::Angelicae Sinensis Radix is commonly used in traditional Chinese medicine. Pharmacological studies show that Angelicae Sinensis Radix has clear anticoagulant activity. Therefore, in this study, the anticoagulant activity of crude Angelicae Sinensis Radix extracts was investigated by measuring the thrombin times of the...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang L,Huang S,Chen B,Zang XY,Su D,Liang J,Xu F,Liu GX,Shang MY,Cai SQ

    更新日期:2016-03-01 00:00:00

  • Alterations in sulfur amino acid metabolism in mice treated with silymarin: a novel mechanism of its action involved in enhancement of the antioxidant defense in liver.

    abstract::It has been known that silymarin exhibits protective activity against oxidative liver injury induced by various hepatotoxicants, but the underlying mechanism of its beneficial action remains unclear. We determined the alterations in sulfur-containing amino acid metabolism induced by silymarin in association with its e...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kwon DY,Jung YS,Kim SJ,Kim YS,Choi DW,Kim YC

    更新日期:2013-08-01 00:00:00

  • Effects of auxins on growth and saponin production in callus cultures of Panax ginseng.

    abstract::A callus was induced from the petiole of Panax ginseng C. A. Meyer by treatment with 2,4-D. The callus has been maintained on the synthetic media containing 2,4-D as growth factor. Habituated ginseng callus which required no auxin for its growth was induced from a 2,4-D callus by successive treatments with a low conce...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Furuya T,Yoshikawa T,Ishii T,Kajii K

    更新日期:1983-03-01 00:00:00

  • Antiproliferative triterpenoid saponins from the stem of Psychotria sp.

    abstract::Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang CX,Zhang DM,Chen MF,Guan SY,Yao JH,He XX,Lei LF,Zhong Y,Wang ZF,Ye WC

    更新日期:2013-07-01 00:00:00