Abstract:
:Eight new lupane triterpenes, including 7beta-cis-coumaroylbetulinic acid (1), 7beta-trans-coumaroylbetulinic acid (2), 7beta-cis-coumaroyl-3-epi-betulinic acid (3), 7beta-trans-coumaroyl-3-epi-betulinic acid (4), 7beta-cis-coumaroylbetulonic acid (5), 7beta-trans-coumaroylbetulonic acid (6), 7beta-hydroxybetulinaldehyde (7) and 28-norlup-20(29)-ene-3alpha,17beta-diol (8), together with fifteen known compounds were isolated from the bioactive methanol extract of the stems of Perrottetia arisanensis. The structures of the new compounds were elucidated by spectroscopic and HR-ESI-MS analysis. All new compounds were evaluated for their cytotoxicity against six human cancer cell lines. Among them, lupane triterpene coumaroyl esters 1-6 showed moderate cytotoxicity with IC (50) values ranging from 3.75 to 21.29 microM. This is the first report for lupane triterpenes with a phenylpropane moiety substituted at C-7.
journal_name
Planta Medjournal_title
Planta medicaauthors
Du YC,Lin AS,Wu CC,Hsieh PW,Chen YH,Chen IH,Chen SL,Yen HF,Lübken T,Chang FR,Wu YCdoi
10.1055/s-0029-1185438subject
Has Abstractpub_date
2009-06-01 00:00:00pages
848-55issue
8eissn
0032-0943issn
1439-0221journal_volume
75pub_type
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