Abstract:
:Three new dammar-type triterpenoid caffeates (1-3) were isolated from the stalks of Celastrus rosthornianus Loes. Their structures were established through various spectral studies as 3beta,20(S),24(S)-trihydroxyldammar-25-ene 3-caffeate (1), 3beta,20(S),24(R)-trihydroxyldammar-25-ene 3-caffeate (2) and 3beta,20(S),25-trihydroxyldammar-23(Z)-ene 3-caffeate (3), respectively. The three new compounds (1-3) showed strong antitumor activity against the human cervical squamous carcinoma cell line with IC (50) values of 6.4, 5.3 and 6.5 microg/mL, respectively. The biological analyses of 1-3 and their hydrolysates 1a-3a indicated that the caffeoyl group could increase the bioactivity.
journal_name
Planta Medjournal_title
Planta medicaauthors
Wang KW,Sun CR,Wu XD,Pan YJdoi
10.1055/s-2005-916214subject
Has Abstractpub_date
2006-03-01 00:00:00pages
370-2issue
4eissn
0032-0943issn
1439-0221journal_volume
72pub_type
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