Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri.

Abstract:

:Sangre de Grado extract used by Peruvian natives as a cicatrizant agent, was collected from trees of the species Croton lechleri growing in the Peruvian jungle. The Sangre de Grado was found to contain one alkaloid identified as taspine and which was shown to be the active cicatrizant principle by an in vivo test in mice. This alkaloid exhibited a dose-related cicatrizant effect and an ED50 of 0.375 mg/kg. Experiments with taspine hydrochloride in order to study its mechanism of action in cell culture systems showed that the alkaloid was non-toxic to human foreskin fibroblasts at concentrations below 150 ng/ml and that it had no effect on cell proliferation. On the other hand, taspine hydrochloride was found to increase the migration of human foreskin fibroblasts. This effect on the migration of fibroblasts is probably the mechanism by which Sangre de Grado and taspine hydrochloride accelerate the wound healing process. Using the two-stage mouse skin carcinogenesis system, we have been able to show that neither Sangre de Grado nor taspine hydrochloride had carcinogenic or tumour promoter activity after 17 months of treatment.

journal_name

Planta Med

journal_title

Planta medica

authors

Vaisberg AJ,Milla M,Planas MC,Cordova JL,de Agusti ER,Ferreyra R,Mustiga MC,Carlin L,Hammond GB

doi

10.1055/s-2006-961907

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

140-3

issue

2

eissn

0032-0943

issn

1439-0221

journal_volume

55

pub_type

杂志文章
  • Evaluation of the Effect of Epilobium angustifolium Aqueous Extract on LNCaP Cell Proliferation in In Vitro and In Vivo Models.

    abstract::Epilobium sp. are commonly used in traditional medicine in the treatment of early stages of benign prostatic hyperplasia and inflammation. It is suggested that a dominating constituent, oenothein B, is responsible for the extracts therapeutic effects. Several bioactivities were established for extracts and oenothein B...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0043-109372

    authors: Piwowarski JP,Bobrowska-Korczak B,Stanisławska I,Bielecki W,Wrzesien R,Granica S,Krupa K,Kiss AK

    更新日期:2017-10-01 00:00:00

  • Single-Lab Validation for Determination of Kavalactones and Flavokavains in Piper methysticum (Kava).

    abstract::Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance for the Pacific Islanders. Kava is also sold as a herbal supplement or recreational beverage consumed for its mild inebriating effect in Europe and North America. With a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-0637-2400

    authors: Liu Y,Lund JA,Murch SJ,Brown PN

    更新日期:2018-11-01 00:00:00

  • Determination of Acid and Neutral Cannabinoids in Extracts of Different Strains of Cannabis sativa Using GC-FID.

    abstract::Cannabis (Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two major phytocannabinoids accounting for over 40% of the cannabis plant extracts, depending on the variety. At the University of Mississippi, differ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0043-124088

    authors: Ibrahim EA,Gul W,Gul SW,Stamper BJ,Hadad GM,Abdel Salam RA,Ibrahim AK,Ahmed SA,Chandra S,Lata H,Radwan MM,ElSohly MA

    更新日期:2018-03-01 00:00:00

  • Equol but not genistein improves early metaphyseal fracture healing in osteoporotic rats.

    abstract::Healing of predominantly metaphyseal fractures in postmenopausal osteoporosis is delayed and comparatively poor. Hormone replacement therapy could improve fracture healing, but, because of its potential side effects, natural alternatives are more appealing. The aim of this study was to determine if the soy metabolite ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185380

    authors: Kolios L,Sehmisch S,Daub F,Rack T,Tezval M,Stuermer KM,Stuermer EK

    更新日期:2009-04-01 00:00:00

  • Isolation and Structure of Neriucoumaric and Isoneriucoumaric Acids from the Leaves of Nerium oleander.

    abstract::Two new coumaryloxy triterpenoids, neriucoumaric and isoneriucoumaric acids, have been isolated from fresh, undried and uncrushed leaves of NERIUM OLEANDER and their structures established as 3beta-hydroxy-2alpha-cis- P-coumaryloxy-urs-12-en-28-oic acid and 3beta-hydroxy-2alpha- TRANS- P-coumaryloxy-urs-12-en-28-oic a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962763

    authors: Siddiqui S,Siddiqui BS,Hafeez F,Begum S

    更新日期:1987-10-01 00:00:00

  • Rhealba® oat plantlet extract: evidence of protein-free content and assessment of regulatory activity on immune inflammatory mediators.

    abstract::Owing to their high content of flavonoids and saponins, plantlets of Avena sativa L. (Poaceae) are likely to possess anti-inflammatory and immunoregulatory properties of value in the treatment of atopic dermatitis (AD). With a view to its potential use in atopic subjects at risk of developing sensitisation to dietary ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250649

    authors: Mandeau A,Aries MF,Boé JF,Brenk M,Crebassa-Trigueros V,Vaissière C,Teysseyre V,Bieber T

    更新日期:2011-06-01 00:00:00

  • Antispasmodic effects of myrrh due to calcium antagonistic effects in inflamed rat small intestinal preparations.

    abstract::Myrrh is the oleo-gum resin of mainly Commiphora molmol and as a powdered substance, one compound in the traditional medicinal product Myrrhinil-Intest®, which has been used for the treatment of unspecific, inflammatory intestinal disorders. The aim of the present study was to evaluate the antispasmodic effect of myrr...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0034-1383391

    authors: Vissiennon C,Goos KH,Goos O,Nieber K

    更新日期:2015-01-01 00:00:00

  • Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells.

    abstract::Twelve phenolic compounds, including three stilbenes, two flavonoids, two coumarins, one neolignan, and four lignans, isolated from Euphorbia and Pycnanthus species or obtained by derivatization, were assayed for their potential antineoplastic efficacy in three human cancer cell lines: gastric (EPG85-257), pancreatic ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1240892

    authors: Duarte N,Lage H,Abrantes M,Ferreira MJ

    更新日期:2010-07-01 00:00:00

  • Protective Effects of α-Boswellic Acids in a Pulmonary Arterial Hypertensive Rat Model.

    abstract::The purpose of this study was to observe the protective effects of α-boswellic acids on hypoxia-induced pulmonary vascular structural remodeling in pulmonary arterial smooth muscle cells in a hypertensive rat model. Pulmonary arterial smooth muscle cells were cultured and then randomly divided into four groups: normox...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-109069

    authors: Xiao B,Zhang G,Ali Sheikh MS,Shi R

    更新日期:2017-01-01 00:00:00

  • Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens.

    abstract::Extracts from Bupleurum fruticescens were examined for oral and topical anti-inflammatory activities. The BuOH extract proved to be active against carrageenan and tetradecanoylphorbol acetate acute edemas and allowed the isolation of three saponins identified by spectroscopic techniques as 3 beta-O-(O-alpha-L-rhamnopy...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957469

    authors: Just MJ,Recio MC,Giner RM,Cuéllar MJ,Máñez S,Bilia AR,Ríos JL

    更新日期:1998-06-01 00:00:00

  • Pyrrolizidine alkaloids from Eupatorium portoricense.

    abstract::Three pyrrolizidine alkaloids were isolated from Eupatorium portoricense and their structures elucidated by spectroscopic methods as (-)-viridifloryl-supinidine (amabiline), (-)-viridifloryl-heliotridine (echinatine), and C12- O-acetyl-(-)-viridifloryl-heliotridine (O(12)-acetylechinatine). ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-958112

    authors: Wiedenfeld H,Guerrero R,Roeder E

    更新日期:1995-08-01 00:00:00

  • Studies on hernandiaceae VI. Lignans and alkaloids of Hernandia guianensis.

    abstract::The lignoidic and alkaloidal content of the leaves, stem barks and root barks of H. GUIANENSIS has been studied; two aryltetrahydronaphthalenes, two dibenzylbutyrolactones and nine alkaloids are isolated. All components are identified by means of the spectral analysis. Eight alkaloids are aporphines and nor-aporphines...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969610

    authors: Richomme P,Lavault M,Jacquemin H,Bruneton J

    更新日期:1984-02-01 00:00:00

  • Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats.

    abstract::The phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in Arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. Using LC/MS/MS, three novel metabolites of arctigenin, namely, arctigenic acid, arctig...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328332

    authors: Gao Q,Zhang Y,Wo S,Zuo Z

    更新日期:2013-04-01 00:00:00

  • Guaianolides from Lactuca saligna.

    abstract::The phytochemical investigation of the aerial parts of LACTUCA SALIGNA L. revealed the presence of lactucin, lactucopicrin, and a new guaianolide named 11beta,13-dihydrolactucopicrin. The structural configuration was established through spectral data. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960064

    authors: Khalil AT,El-Fattah HA,Mansour ES

    更新日期:1991-04-01 00:00:00

  • Determination of Final Steps in Biosyntheses of Essential Oil Components in Perilla frutescens.

    abstract::Biosynthetic pathways of the essential oil components in PERILLA FRUTESCENS were examined by tracer experiments using [ (14)C]-labeled sucrose on two chemotypes: perillaketone (PK) and phenylpropanoid (PP-EM) types. The results of the experiments indicated that perillaketone is not converted from isoegomaketone but is...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961996

    authors: Nishizawa A,Honda G,Tabata M

    更新日期:1989-06-01 00:00:00

  • Gastric cytoprotective anti-ulcerogenic actions of hydroxychalcones in rats.

    abstract::The preventive effects of hydroxychalcone derivatives on ulcer formation induced by severe necrotizing agents such as 60% ethanol in 150 mM HCl (HCl-ethanol) and 0.2 N NaOH in rats were examined. Among the compounds tested, 2',4'-dihydroxychalcone gave the strongest activity in both experimental models and protected t...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961498

    authors: Yamamoto K,Kakegawa H,Ueda H,Matsumoto H,Sudo T,Miki T,Satoh T

    更新日期:1992-10-01 00:00:00

  • Galanthindole: a new indole alkaloid from Galanthus plicatus ssp. byzantinus.

    abstract::A new indole alkaloid, galanthindole, was isolated from Galanthus plicatus ssp. byzantinus (Amaryllidaceae), a plant native to northwestern Turkey. Incorporating a non-fused indole ring, galanthindole may represent the prototype of a new subgroup of the Amaryllidaceae alkaloids. Two other bases, (+)-11-hydroxyvittatin...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-43206

    authors: Unver N,Kaya GI,Werner C,Verpoorte R,Gözler B

    更新日期:2003-09-01 00:00:00

  • New triterpenoids from Kadsura heteroclita and their cytotoxic activity.

    abstract::Phytochemical investigations of the stem of Kadsura heteroclita (Roxb) Craib (Schizandraceae) resulted in the isolation and structure elucidation of six new triterpenoidal compounds named heteroclitalactones A-E (1-5) as well as heteroclic acid (6) and heteroclitalactone F (7), which was isolated for the first time fr...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-916263

    authors: Wang W,Liu J,Han J,Xu Z,Liu R,Liu P,Wang W,Ma X,Guan S,Guo D

    更新日期:2006-04-01 00:00:00

  • Taxol and related compounds in Korean native yews (Taxus cuspidata).

    abstract::The concentrations of taxol and related compounds in the bark and needles of Taxus cuspidata grown on Mt. Jiri, Mt. Sobaek, and Cheju Island, and T. cuspidata var. latifolia on Ullung Island in Korea were determined by high performance liquid chromatography (HPLC). The taxane content significantly varied with the loca...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958069

    authors: Choi MS,Kwak SS,Liu JR,Park YG,Lee MK,An NH

    更新日期:1995-06-01 00:00:00

  • Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.

    abstract::Valeriana officinalis L. is a popular herbal treatment for mild sleep disorders. Clinical and non-clinical studies found contradictory results for valerian extracts and single constituents regarding the influence on sleep parameters. It was the aim of this study to investigate the sedative effects of a valerian root e...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250589

    authors: Chow NK,Fretz M,Hamburger M,Butterweck V

    更新日期:2011-05-01 00:00:00

  • Phytochemical Study of Eryngium triquetrum: Isolation of Polyacetylenes and Lignans.

    abstract::Phytochemical investigation of the ethyl acetate extract from the aerial parts of Eryngium triquetrum Vahl resulted in the isolation of new polyacetylenes, triquetridiol (6) and trans-epoxy-triquetrol (7a/7b, diastereomeric mixture), and the lignan demethoxy carolignan Z (8a/8b, erythro/threo pair), together with a se...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-110316

    authors: Bouzergoune F,Ciavatta ML,Bitam F,Carbone M,Aberkane MC,Gavagnin M

    更新日期:2016-11-01 00:00:00

  • Structural Characterization and Anti-complementary Activities of Two Polysaccharides from Houttuynia cordata.

    abstract::In previous studies, crude Houttuynia cordata polysaccharides showed beneficial effects on acute lung injury in vivo, a syndrome in which anti-complementary activities played an important role. Anti-complementary activity-guided fractionation of H. cordata polysaccharides led to the isolation of two highly branched ho...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-0955-7841

    authors: Lu Y,Zhang JJ,Huo JY,Chen DF

    更新日期:2019-09-01 00:00:00

  • Quality control of herbal material and phytopharmaceuticals with MS and NMR based metabolic fingerprinting.

    abstract::Metabolic fingerprinting techniques have received a lot of attention in recent years and the annual amount of publications in this field has increased significantly over the past decade. This increase in publications is due to improvements in the analytical performance, most notably in the field of NMR and MS analysis...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1185450

    authors: van der Kooy F,Maltese F,Choi YH,Kim HK,Verpoorte R

    更新日期:2009-06-01 00:00:00

  • Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats.

    abstract::ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-122344

    authors: Anukunwithaya T,Tantisira MH,Tantisira B,Khemawoot P

    更新日期:2017-05-01 00:00:00

  • New triterpenoids from the leaves of Cyclocarya paliurus.

    abstract::Six new triterpenoids including four new secodammarane triterpenoid glycosides (1-4), an epoxydammarane triterpenoid glycoside (5), and a new secodammarane triterpenoid (6) were isolated from the ethanolic extract of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1280411

    authors: Li S,Cui B,Liu Q,Tang L,Yang Y,Jin X,Shen Z

    更新日期:2012-02-01 00:00:00

  • Evaluation of the anti-trypanosomal activity of tyropeptin A.

    abstract::The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times low...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-931600

    authors: Steverding D,Pemberton AJ,Royle H,Spackman RW,Rivett AJ

    更新日期:2006-06-01 00:00:00

  • Taxol biosynthesis: an update.

    abstract::The novel diterpenoid taxol (paclitaxel) is now well-established as a potent chemotherapeutic agent. Total synthesis of the drug is not commercially feasible and, in the foreseeable future, the supply of taxol and its synthetically useful progenitors must rely on biological methods of production. The first three steps...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-2006-957684

    authors: Hezari M,Croteau R

    更新日期:1997-08-01 00:00:00

  • Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells.

    abstract::The involvement of unfolded protein response (UPR) activation in tumor survival and resistance to chemotherapies suggests a new anticancer strategy targeting UPR pathway. Arctigenin, a natural product, has been recently identified for its antitumor activity with selective toxicity against cancer cells under glucose st...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250179

    authors: Sun S,Wang X,Wang C,Nawaz A,Wei W,Li J,Wang L,Yu DH

    更新日期:2011-01-01 00:00:00

  • A new strain of Claviceps purpurea accumulating tetracyclic clavine alkaloids.

    abstract::A new strain of Claviceps was isolated from a blokked mutant of Claviceps purpurea. This strain accumulates substantial amounts of clavine alkaloids (2 g/l). The alkaloid fraction is composed of chanoclavine-I ( approximately 10%) and a mixture of agroclavine/elymoclavine (90%). Most suitable for alkaloid production i...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971231

    authors: Schumann B,Erge D,Maier W,Gröger D

    更新日期:1982-05-01 00:00:00

  • Hypoglycemic activity of olive leaf.

    abstract::The hypoglycemic activity of olive leaf was studied. Maximum hypoglycemic activity was obtained from samples collected in the winter months, especially in February. One of the compounds responsible for this activity was oleuropeoside, which showed activity at a dose of 16 mg/kg. This compound also demonstrated antidia...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961538

    authors: Gonzalez M,Zarzuelo A,Gamez MJ,Utrilla MP,Jimenez J,Osuna I

    更新日期:1992-12-01 00:00:00