Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa.


:The antimycobacterial quinolones 1-methyl-2-undecyl-4-quinolone, dihydroevocarpine and evocarpine as well as the indoloquinazoline alkaloids rutaecarpine and evodiamine - all from the Chinese medicinal herb Evodia rutaecarpa - were tested in two in vitro assays, for cytotoxicity and interaction with p-glycoprotein (p-gp). Cytotoxicity was measured in a cell proliferation assay against CCRF-CEM leukemia cells and their p-gp over-expressing subline CEM/ADR5000. An assay monitoring the p-gp-dependent accumulation of the dye calcein in porcine brain capillary endothelial cells (PBCECs) was used to study interactions of the test substances with this efflux pump. Rutaecarpine and evodiamine showed quite high toxicity with IC (50) values from 2.64 to 4.53 microM and were weak modulators of p-gp activity. The degrees of resistance in CEM/ADR5000 towards the saturated quinolones 1-methyl-2-undecyl-4-quinolone and dihydroevocarpine were between 3 and 4. In the calcein assay, these two quinolones were shown to be moderate modulators of p-gp activity. Evocarpine, on the other side, is not transported by p-gp, and showed only slight toxicity at the highest test concentration of 30 microM.


Planta Med


Planta medica


Adams M,Mahringer A,Kunert O,Fricker G,Efferth T,Bauer R




Has Abstract


2007-12-01 00:00:00












  • Chemical constituents from the stem bark of Trewia nudiflora L. and their antioxidant activities.

    abstract::Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4- O- beta-(6''- O-galloyl)-glucopyranoside ( 1), 4,4'- O-dimethylellagic acid 3-(2''- O-acetyl)- alpha-rhamnopyranoside ( 2), and ethyl O- beta-(6'-galloyl)-glucopyranoside ( 3), together with eleven known ones, were isolated from the stem bark of Tre...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kang QJ,Yang XW,Wu SH,Ma YL,Li L,Shen YM

    更新日期:2008-03-01 00:00:00

  • Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay.

    abstract::Blue cohosh, Caulophyllum thalictroides (L.) Michx. is a popular herb, roots and rhizomes of which have been extensively used for women's health. Alkaloids and saponins are considered to be responsible for its pharmacological effects. In this investigation the methanolic extract of the roots of blue cohosh, the alkalo...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Madgula VL,Ali Z,Smillie T,Khan IA,Walker LA,Khan SI

    更新日期:2009-03-01 00:00:00

  • Differentiation of the traditional Chinese medicinal plants Euphorbia humifusa and E. maculata from adulterants by TaqMan real-time polymerase chain reaction.

    abstract::DNA sequence analysis of the rDNA internal transcribed spacer 1 (ITS1) and TaqMan real-time polymerase chain reaction were exploited for their applications in the differentiation of the traditional chinese medicinal plants euphorbia humifusa and e. maculata from three related adulterants e. hypericifolia, E. atoto and...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xue HG,Wang H,Li DZ,Xue CY,Wang QZ

    更新日期:2008-02-01 00:00:00

  • A method for the quantitative determination of anthraquinones and alkaloids in cell and tissue cultures of cinchona sp.

    abstract::A procedure is described for the extraction of both anthraquinones and alkaloids from tissue culture material of CINCHONA species. Using this extraction method, it is possible to quantitatively determine the two groups of secondary metabolites produced in CINCHONA tissue cultures. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wijnsma R,van Vliet TB,Harkes PA,van Groningen HJ,van der Heijden R,Verpoorte R,Svendsen AB

    更新日期:1987-02-01 00:00:00

  • Steroidal saponins from the rhizomes of Dioscorea bulbifera and their cytotoxic activity.

    abstract::Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3- 7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3- O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic acti...

    journal_title:Planta medica

    pub_type: 信件


    authors: Liu H,Chou GX,Wang JM,Ji LL,Wang ZT

    更新日期:2011-05-01 00:00:00

  • Three new alkaloids from Galanthus nivalis and Galanthus elwesii.

    abstract::Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3''-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3'-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3,11,3'-O-(3'...

    journal_title:Planta medica

    pub_type: 信件


    authors: Berkov S,Cuadrado M,Osorio E,Viladomat F,Codina C,Bastida J

    更新日期:2009-10-01 00:00:00

  • Inhibition of activator protein 1 activity by berberine in human hepatoma cells.

    abstract::Activator protein 1 (AP-1) is a transcription factor which plays a critical role in inflammation and carcinogenesis. The present study was conducted to investigate the effect of berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, on the activity of AP-1 using a reporter gene assay ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Fukuda K,Hibiya Y,Mutoh M,Koshiji M,Akao S,Fujiwara H

    更新日期:1999-05-01 00:00:00

  • Evaluation of cytotoxic activity of Schisandra chinensis lignans.

    abstract::Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Smejkal K,Slapetová T,Krmenčík P,Babula P,Dall'Acqua S,Innocenti G,Vančo J,Casarin E,Carrara M,Kalvarová K,Dvorská M,Slanina J,Kramářová E,Julínek O,Urbanová M

    更新日期:2010-10-01 00:00:00

  • Arsenic trioxide-enhanced, matrine-induced apoptosis in multiple myeloma cell lines.

    abstract::Matrine and arsenic trioxide are monomers used in traditional Chinese medicine possessing anti-myeloma activities. In this study, we evaluated the effects and mechanisms of matrine, arsenic trioxide, and their combination therapy on the proliferation and apoptosis of the myeloma cell lines RPMI8226 and U266. The effec...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yu Q,Chen B,Zhang X,Qian W,Ye B,Zhou Y

    更新日期:2013-06-01 00:00:00

  • Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.

    abstract::Three flavonoids: norwogonin, dihydronorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC 50 = 1.1 microM), dihydronorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) sh...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee MS,Oh WK,Kim BY,Ahn SC,Kang DO,Sohn CB,Osada H,Ahn JS

    更新日期:2002-12-01 00:00:00

  • Cytotoxicity, apoptosis and DNA damage induced by Alpinia galanga rhizome extract.

    abstract::Alpinia galanga, or galangal, has been a popular condiment used in Thai and Asian cuisine for many years. However, relatively little is known of the potential beneficial or adverse health effects of this spice. This study was conducted to analyze the capacity of galangal extract to induce cytotoxicity and DNA damage i...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Muangnoi P,Lu M,Lee J,Thepouyporn A,Mirzayans R,Le XC,Weinfeld M,Changbumrung S

    更新日期:2007-07-01 00:00:00

  • Kanerocin: A New Triterpene from the Leaves of Nerium oleander.

    abstract::From the fresh, undried, and uncrushed leaves of NERIUM OLEANDER a new triterpenoid, kanerocin, has been isolated along with known ursolic and oleanolic acids and its structure established through chemical and spectroscopic methods as 3alpha-hydroxy-urs-18,20-dien-28-oic acid. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Siddiqui S,Siddiqui BS,Begum S,Hafeez F

    更新日期:1989-06-01 00:00:00

  • Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation.

    abstract::We have examined the immunosuppressive effects of representative ginsenosides (Rb1, Rb2, Re and Rg1) from Panax ginseng C. A. Meyer on CD4+ and CD8+ lymphocyte proliferation. Ginsenosides differentially modulated lymphocyte proliferation induced by concanavalin A (Con A), lipopolysaccharide (LPS), phytohemaglutinin (P...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Cho JY,Kim AR,Yoo ES,Baik KU,Park MH

    更新日期:2002-06-01 00:00:00

  • Dihydrogoniothalamin, an Endothelium and NO-Dependent Vasodilator Drug Isolated from Aniba panurensis.

    abstract::Dihydrogoniothalamin is a styrylpyrone isolated from the leaves of Aniba panurensis. The present work aimed at investigating the vasorelaxant activity of dihydrogoniothalamin and its underlying mechanism of action in the rat aorta. Dihydrogoniothalamin (0.01-100 µM) induced a concentration-dependent vasodilatation of ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Rezende BA,Silva GC,Corradi RG,Teles MM,Barbosa-Filho JM,Lemos VS,Cortes SF

    更新日期:2015-10-01 00:00:00

  • Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium.

    abstract::Products of lipoxygenase metabolism play a role in the pathogenesis of psoriasis. Four protoberberine alkaloids, berberine, oxyberberine, jatrorrhizine, columbamine, and two aporphine alkaloids, magnoflorine, and corytuberine, isolated from Mahonia aquifolium, were tested for lipoxygenase inhibition. Oxyberberine, cor...

    journal_title:Planta medica

    pub_type: 信件


    authors: Misík V,Bezáková L,Máleková L,Kostálová D

    更新日期:1995-08-01 00:00:00

  • The structure and the stereochemistry of atractyliretin.

    abstract::The nor-kaurane diterpene Atractyliretin was obtained by acid hydrolysis of Atractyloside, a toxic substance isolated from ATRACTYLIS GUMMIFERA L (Compositae). On the basis of spectral (IR, (1)H-NMR, (13)C-NMR and MS) analysis and chemical degradation its structure and stereochemistry was identified as 4. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Camarda L,Ceraulo L,Ferrugia M,Pascual C,Sprio V

    更新日期:1986-10-01 00:00:00

  • Improved method for the determination of oxindole alkaloids in Uncaria tomentosa by high performance liquid chromatography.

    abstract::This Paper describes an improved HPLC method for the determination of pentacyclic oxindole alkaloids in Uncaria tomentosa (Cat's Claw). Six of the isomeric compounds could be baseline separated at room temperature within less than 30 min by using 3 microm C-18 column material and a mobile phase consisting of 10 mM pho...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ganzera M,Muhammad I,Khan RA,Khan IA

    更新日期:2001-07-01 00:00:00

  • Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.

    abstract::In this study we investigated the effects of concomitant food intake on the bioavailability of distinct boswellic acids (BAs) from the test preparation BSE-018, a dry extract from Boswellia serrata gum resin. In a randomised, open, single-dose, two-way crossover study, healthy male subjects received three capsules of ...

    journal_title:Planta medica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sterk V,Büchele B,Simmet T

    更新日期:2004-12-01 00:00:00

  • Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus.

    abstract::Lead is a well-known toxin in the environment that causes severe damage to the nervous system. Gastrodin is the main bioactive component of Tian ma ( GASTRODIA ELATA Bl.), which is a traditional herbal medicine widely used in eastern Asia. Increasing lines of evidence show that gastrodin has diverse effects, especiall...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yong W,Xing TR,Wang S,Chen L,Hu P,Li CC,Wang HL,Wang M,Chen JT,Ruan DY

    更新日期:2009-08-01 00:00:00

  • Ecological and Pharmacological Activities of Antarctic Marine Natural Products.

    abstract::Antarctic benthic communities are regulated by abundant interactions of different types among organisms, such as predation, competition, etc. Predators are usually sea stars, with omnivorous habits, as well as other invertebrates. Against this strong predation pressure, many organisms have developed all sorts of defen...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Avila C

    更新日期:2016-06-01 00:00:00

  • Antitumor activity of taspine by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo.

    abstract::EGFR, as a critical signaling pathway in many human tumors, has become an important target of cancer drug design. Taspine has shown meaningful angiogenesis activity in previous studies. This paper is to investigate the antitumor action of taspine by modulating the EGFR signaling pathway. The study determined the expre...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang Y,Zheng L,Zhang J,Dai B,Wang N,Chen Y,He L

    更新日期:2011-11-01 00:00:00

  • An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions.

    abstract::We have previously shown that 11 ent-kauranes isolated from the stems of Annona squamosa exhibited immunomodulating effects in leukocytes. In this study, a cellular model using isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yeh SH,Chang FR,Wu YC,Yang YL,Zhuo SK,Hwang TL

    更新日期:2005-10-01 00:00:00

  • (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-perhydro-1,4-oxazine-2,5-dione: an apoptosis-inducer from the fruiting bodies of Isaria japonica.

    abstract::(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione (1) was isolated from the fruiting bodies of Isaria japonica as an apoptosis-inducing agent. The complete structural assignment of the compound was accomplished on the basis of spectroscopic methods and chemical transformations. Compound 1...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Oh H,Kim T,Oh GS,Pae HO,Hong KH,Chai KY,Kwon TO,Chung HT,Lee HS

    更新日期:2002-04-01 00:00:00

  • Changes in the histomorphometric and biomechanical properties of the proximal femur of ovariectomized rat after treatment with the phytoestrogens genistein and equol.

    abstract::The isoflavonoids found in soy have attracted great interest as dietary phytoestrogens that might be effective for postmenopausal hormone replacement therapy. Special attention has been devoted to the hormonal effects of various isoflavonoids, like genistein (GEN) and daidzein's (DAID) potent metabolite, equol (EQ). H...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Tezval M,Sehmisch S,Seidlová-Wuttke D,Rack T,Kolios L,Wuttke W,Stuermer KM,Stuermer EK

    更新日期:2010-02-01 00:00:00

  • New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata.

    abstract::As part of a study on chemical constituents of Camptotheca species, one new natural camptothecin analogue (2), two new alkaloids (3, 4), one new ellagic acid analogue (5), and 19 known compounds (1, 6-23) have been isolated from the root bark, stem bark, fruits, and leaves of Camptotheca acuminata Decaisne. The struct...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang Z,Li S,Zhang S,Liang C,Gorenstein D,Beasley RS

    更新日期:2004-12-01 00:00:00

  • Inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (Curcuma longa).

    abstract::Turmeric has been extensively utilized in Indian and Chinese medicine for its immune-modulatory properties. Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and regulate immunity. The ability of DCs to initiate immunity is linked to their activation status. The effects of turmeric on human DC...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Krasovsky J,Chang DH,Deng G,Yeung S,Lee M,Leung PC,Cunningham-Rundles S,Cassileth B,Dhodapkar MV

    更新日期:2009-03-01 00:00:00

  • Antiproliferative triterpenoid saponins from the stem of Psychotria sp.

    abstract::Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang CX,Zhang DM,Chen MF,Guan SY,Yao JH,He XX,Lei LF,Zhong Y,Wang ZF,Ye WC

    更新日期:2013-07-01 00:00:00

  • Studies on the endocrine effects of the contents of Cimicifuga racemosa:.

    abstract::Endocrine activity can be demonstrated for components of the rhizome of CIMICIFUGA RACEMOSA using ovariectomized rats as experimental model. A selective reduction of the serum concentration of the pituitary luteinizing hormone (LH) takes place upon application of an extract. The active principle can be concentrated by...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jarry H,Harnischfeger G

    更新日期:1985-02-01 00:00:00

  • Standardization and in vivo antioxidant activity of ethanol extracts of fruit and leaf of Piper sarmentosum.

    abstract::The present study aimed to investigate standardized ethanol extracts of fruit and leaves of Piper sarmentosum for their in vivo antioxidant activity in rats using a CCl (4)-induced oxidative stress model. The standardization was based on the quantification of the markers pellitorine, sarmentine and sarmentosine by hig...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hussain K,Ismail Z,Sadikun A,Ibrahim P

    更新日期:2010-03-01 00:00:00

  • Network Pharmacology Uncovers Anticancer Activity of Mammea-Type Coumarins from Calophyllum brasiliense.

    abstract::Mammea-type coumarins are a particular type of secondary metabolites biosynthesized by the tropical rainforest tree Calophyllum Brasiliense, which is distributed from South America to Mexico. Particularly, mammea A/BA and A/BB (alone or as a mixture) possess biological properties such as cytotoxic and antitumoral acti...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Gómez-Verjan JC,Rivero-Segura NA,Estrella-Parra E,Rincón-Heredia R,Madariaga-Mazón A,Flores-Soto E,González-Meljem M,Cerbón M,Reyes-Chilpa R

    更新日期:2019-01-01 00:00:00