Abstract:
:Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T-wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bdph (60 mg/kg, p.o.) did not affect systolic pressure and heart rate in unanesthetized rats. Therefore, Bdph, found in the rhizome of Ligusticum chuaxiong Hort. (L. wallichii Franch., Umbelliferae), appears to have selective antianginal effect without changing blood pressure and heart rate.
journal_name
Planta Medjournal_title
Planta medicaauthors
Ko WC,Sheu JR,Tzeng SH,Chen CMdoi
10.1055/s-2006-957415subject
Has Abstractpub_date
1998-04-01 00:00:00pages
229-32issue
3eissn
0032-0943issn
1439-0221journal_volume
64pub_type
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