Analgesic, antipyretic and anti-inflammatory properties of Euphorbia hirta.


:Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedative effect, associated with anxiolytic effects. This study leads us to the conclusion that this plant extract exerts central analgesic properties. Such a dose-dependent action was obtained against chemical (writhing test) and thermic (hot plate test) stimuli, respectively, from the doses of 20 and 25 mg/kg and it was inhibited by a naloxone pretreatment, a specific morphinic antagonist compound. An antipyretic activity was obtained at the sedative doses of 100 and 400 mg/kg, on the yeast-induced hyperthermia. Finally, significant and dose-dependent anti-inflammatory effects were observed on an acute inflammatory process (carrageenan-induced edema test in rats) from the dose of 100 mg/kg. On the other hand, plant extract remained inactive on chronic processes such as Freund's adjuvant-induced rheumatoid arthritis, after a chronic treatment during fourteen days at the daily dose of 200 or 400 mg/kg; however, if inefficacy was observed on rat backpaws edema and on loss of weight, the aqueous extract reduced the inflammatory hyperalgia.


Planta Med


Planta medica


Lanhers MC,Fleurentin J,Dorfman P,Mortier F,Pelt JM




Has Abstract


1991-06-01 00:00:00












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    abstract::This paper studies the effect of different concentrations of ethephon on the levels of the sesquiterpene, nootkatone, and of the flavanones, naringin and narirutin, in grapefruit fruits. The results show that nootkatone synthesis and/or accumulation was stimulated by all the concentrations of ethephon assayed, while t...

    journal_title:Planta medica

    pub_type: 信件


    authors: Puig DG,Pérez ML,Fuster MD,Ortuño A,Sabater F,Porras I,Lidón AG,Del Río JA

    更新日期:1995-06-01 00:00:00

  • Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines.

    abstract::Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative act...

    journal_title:Planta medica

    pub_type: 信件


    authors: Marques CG,Pedro M,Simões MF,Nascimento MS,Pinto MM,Rodríguez B

    更新日期:2002-09-01 00:00:00

  • The Effects of a Fixed Combination of Berberis aristata and Silybum marianum on Dyslipidaemia - A Meta-analysis and Systematic Review.

    abstract::A fixed combination of Berberis aristata and Silybum marianum (Berberol) has been used by patients with dyslipidaemia. The aim of the present meta-analysis was to systematically evaluate the efficacy and safety of a fixed combination of B. aristata and S. marianum (Berberol) on serum lipid levels compared to placebo i...

    journal_title:Planta medica

    pub_type: 杂志文章,meta分析


    authors: Tóth B,Németh D,Soós A,Hegyi P,Pham-Dobor G,Varga O,Varga V,Kiss T,Sarlós P,Erőss B,Csupor D

    更新日期:2020-01-01 00:00:00

  • [About major alkaloids of Strychnos scheffleri from Zaire].

    abstract::Leaves and stem barks of S. scheffleri Gilg afforded eight dihydroindole alkaloids. Four tertiary monomers (O-methyl Na-acetylstrychnosplendine, Na-acetylstrychnosplendine, strychnobrasiline and strychnofendlerine) have been isolated from leaf material while stem barks yielded one tertiary monomer (desacetylisoretulin...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Caprasse M,Angenot L

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  • Bioactivity-guided isolation of cytotoxic sesquiterpenes and flavonoids from Anthemis ruthenica.

    abstract::A new eudesmanolide sesquiterpene, sivasinolide 6-O-angelate (1), was isolated from the aerial parts of Anthemis ruthenica together with the known compounds chrysanin (2), tanacin (3), 3 beta-hydroxycostunolide (4), centauridin (5), and centaureidin (6). The compounds were obtained by means of bioactivity-guided fract...

    journal_title:Planta medica

    pub_type: 信件


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    journal_title:Planta medica

    pub_type: 杂志文章


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    更新日期:2001-08-01 00:00:00

  • A DNA-damaging sesquiterpene and other constituents from Frullania nisquallensis.

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    authors: Kim YC,da S Bolzani V,Baj N,Gunatilaka AA,Kingston DG

    更新日期:1996-02-01 00:00:00

  • Alkaloids from Papaver triniifolium of Turkish Origin1.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sariyar G

    更新日期:1983-09-01 00:00:00

  • Shogaols from Zingiber officinale protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25-35) insult.

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    journal_title:Planta medica

    pub_type: 信件


    authors: Kim DS,Kim DS,Oppel MN

    更新日期:2002-04-01 00:00:00

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  • A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa.

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    journal_title:Planta medica

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    authors: Rasmussen HB,Christensen SB,Kvist LP,Karazmi A

    更新日期:2000-05-01 00:00:00

  • Single-Lab Validation for Determination of Kavalactones and Flavokavains in Piper methysticum (Kava).

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Liu Y,Lund JA,Murch SJ,Brown PN

    更新日期:2018-11-01 00:00:00

  • High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia.

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  • Cytotoxic coumarins from the aerial parts of Tordylium apulum and their effects on a non-small-cell bronchial carcinoma line.

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    更新日期:1998-03-01 00:00:00

  • Identification of New Diterpenes as Putative Marker Compounds Distinguishing Agnus Castus Fruit (Chaste Tree) from Shrub Chaste Tree Fruit (Viticis Fructus).

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    pub_type: 信件


    authors: Bae EA,Han MJ,Kim DH

    更新日期:1999-06-01 00:00:00

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xu X,Li Y,Hou J,Zhang S,Xu Y,Wang Y,Zhang Y,Liu C,He X

    更新日期:2011-09-01 00:00:00

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    pub_type: 信件


    authors: Zhaxi M,Chen L,Li X,Komatsu K,Yao X,Qiu F

    更新日期:2010-03-01 00:00:00

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    abstract::Embelia ribes Burm. f. (Myrsinaceae) is one of the important plants used in Indian traditional medicine. RAPD-PCR analysis was performed to obtain species-specific DNA fragments. A band of 906 bp that was specific to Embelia ribes irrespective of the geographical source was obtained using the random decamer primer OPF...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Devaiah KM,Venkatasubramanian P

    更新日期:2008-02-01 00:00:00

  • GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus.

    abstract::The gamma-amino butyric acid (GABA) type A (GABA(A)) receptor represents a crucial target for clinical agents in the treatment of anxiety and insomnia. Using the two-microelectrode voltage clamp technique on recombinant α₁β₂γ(2S) GABA (A) receptors, effusol (1) and dehydroeffusol (2) were isolated in a bioactivity-gui...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Singhuber J,Baburin I,Khom S,Zehl M,Urban E,Hering S,Kopp B

    更新日期:2012-03-01 00:00:00

  • Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hu K,Yao X

    更新日期:2002-04-01 00:00:00

  • Stimulation of Indole Alkaloid Production in Cell Suspension Cultures of Catharanthus roseus by Abscisic Acid.

    abstract::When added to suspension cultures of CATHARANTHUS ROSEUS, abscisic acid (ABA) stimulated intracellular accumulation of the indole alkaloids catharanthine and ajmalicine in both flask and 30 litre fermenter-scale systems. The response varied, and depended upon the cell line, the concentration and source of the ABA, and...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Smith JI,Smart NJ,Kurz WG,Misawa M

    更新日期:1987-10-01 00:00:00

  • Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Habtemariam S

    更新日期:1997-02-01 00:00:00

  • Activity on the central nervous system of Himanthalia elongata.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Anca JM,Lamela M,Calleja JM

    更新日期:1993-06-01 00:00:00

  • Cloning and characterization of a cDNA coding a hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase involved in chlorogenic acid biosynthesis in Lonicera japonica.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Peng X,Li W,Wang W,Bai G

    更新日期:2010-11-01 00:00:00

  • Developmental studies of Artemisia annua: flowering and artemisinin production under greenhouse and field conditions.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ferreira JF,Simon JE,Janick J

    更新日期:1995-04-01 00:00:00

  • Rodent models of colon carcinogenesis for the study of chemopreventive activity of natural products.

    abstract::This perspective describes some commonly used animal models for the evaluation of potential chemopreventive agents in colon carcinogenesis. Special emphasis is given to the azoxymethane (AOM)/1,2-dimethylhydrazine (DMH) rat model and APCMIN mice, carrying a mutation in APC, a key gene in human carcinogenesis. In the A...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Femia AP,Caderni G

    更新日期:2008-10-01 00:00:00

  • p-Terphenyl- and phenanthraquinone derivatives: an NMR study.

    abstract::(1)H- and (13)C-NMR spectral data are presented for six p-terphenylquinone derivatives (and for two monosubstituted quinones 1 and 2, used as model compounds) and for 9,10-phenanthraquinone and retenequinone. The chemical shifts were confirmed through correlation spectroscopy and NOE measurements. ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Jokela R,Lounasmaa M

    更新日期:1997-08-01 00:00:00

  • Gradient x Isocratic Elution CCC on the Isolation of Verbascoside and Other Phenylethanoids: Influence of the Complexity of the Matrix.

    abstract::Verbascoside is a phenylethanoid glycoside widely distributed in nature, especially among the order Lamiales, occurring in numerous plants that are constituents of folk medicine preparations. This natural compound, previously isolated by our group from the ethyl acetate extract of Lantana trifolia using the gradient a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Leitão GG,Pinto SC,de Oliveira DR,Timoteo P,Guimarães MG,Cordova WH,Leitão SG

    更新日期:2015-11-01 00:00:00