Abstract:
:This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of the new compounds was obtained as a pair of inseparable diasteriomeric epimers due to the chiral carbon of hemiketal at C-3″. This phenomenon is rooted in the ring-chain tautomerism of the hemiketal functional group in solution, which was proved by dynamic NMR experiments. The new compounds 1-4 displayed inhibitory activities against herpes simplex virus 1, with respective IC50 values of 38.46, 14.10, 62.00 and 70.76 µM, which was associated with the medicinal functions of H. cordata.
journal_name
Planta Medjournal_title
Planta medicaauthors
Chen SD,Li T,Gao H,Zhu QC,Lu CJ,Wu HL,Peng T,Yao XSdoi
10.1055/s-0033-1351051subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1742-8issue
18eissn
0032-0943issn
1439-0221journal_volume
79pub_type
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