Abstract:
:A total of 18 purified lignans was evaluated for antiviral activity against murine cytomegalovirus (CMV) and Sindbis virus, by means of different treatment regimens. Podophyllotoxin and alpha-peltatin were the most potent compounds, and they apparently inhibited murine CMV at an essential early step in the replication cycle after the adsorption of virus to the cells. On the other hand, justicidin B and the diphyllin derivatives were much more effective against Sindbis virus, and 12 of the lignans had no demonstrable effect at all, despite their known activities in other bioassays.
journal_name
Planta Medjournal_title
Planta medicaauthors
MacRae WD,Hudson JB,Towers GHdoi
10.1055/s-2006-962087subject
Has Abstractpub_date
1989-12-01 00:00:00pages
531-5issue
6eissn
0032-0943issn
1439-0221journal_volume
55pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::From leaves of Penstemon barbatus Nutt. a new iridoid glucoside has been isolated. The structure was established mainly by spectroscopic methods ( (1)H-NMR, (13)C-NMR, IR, MS). ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971261
更新日期:1982-06-01 00:00:00
abstract::Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an incre...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0835-6622
更新日期:2019-04-01 00:00:00
abstract::In natural product research, the isolation of biomarkers or bioactive compounds from complex natural extracts represents an essential step for de novo identification and bioactivity assessment. When pure natural products have to be obtained in milligram quantities, the chromatographic steps are generally labourious an...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545912
更新日期:2015-11-01 00:00:00
abstract::Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synerg...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2002-32558
更新日期:2002-06-01 00:00:00
abstract::The steam distilled oils both from flowers and leaves, as well as from total aerial parts of CHRYSANTHEMUM INDICUM L. (small-flowered form), were obtained and analyzed by GC and GC/MS. Their main components are borneol, chrysanthenone and bornyl acetate. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969858
更新日期:1983-12-01 00:00:00
abstract::Three pyrrolizidine alkaloids were isolated from Eupatorium portoricense and their structures elucidated by spectroscopic methods as (-)-viridifloryl-supinidine (amabiline), (-)-viridifloryl-heliotridine (echinatine), and C12- O-acetyl-(-)-viridifloryl-heliotridine (O(12)-acetylechinatine). ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-958112
更新日期:1995-08-01 00:00:00
abstract::The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced. The extract of the herb of Ch.majus als...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957924
更新日期:1996-10-01 00:00:00
abstract::Novel therapies are needed to address the public health problem posed by methicillin-resistant STAPHYLOCOCCUS AUREUS (MRSA). In this study, we determined the effects of combinations of antibiotics and plant polyphenols against 20 clinical isolates of MRSA. The IN VITRO activities of 10 antibiotics and 15 natural polyp...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1074559
更新日期:2008-06-01 00:00:00
abstract::The chloroform extract of Valeriana officinalis led to the isolation of clionasterol-3-O-beta-D-glucopyranoside and a mixture of 6'-O-acyl-beta-D-glucosyl-clionasterols. The acyl moieties were identified as hexadecanoyl, 8 E,11 E-octadecadienoyl and 14-methylpentadecanoyl by alkaline hydrolysis followed by GC-MS analy...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-864179
更新日期:2005-10-01 00:00:00
abstract::The dried rhizome of Panax notoginseng is a traditional Chinese herb extensively used for treatment of cardiovascular diseases and other ailments. Panax notoginseng saponins (PNS) are known as the major pharmacologically active constituents. The purpose of this study was to investigate the cardioprotective effects of ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1034303
更新日期:2008-02-01 00:00:00
abstract::Ocimum basilicum L. is an aromatic herb used in Brazil to treat illnesses such as respiratory and rheumatic problems, vomiting, and pain. In the present study, the chemical composition, acute toxicity, and antinociceptive effects of the essential oil (EO) of the cultivar "Maria Bonita" obtained from O. basilicum L. PI...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250607
更新日期:2011-05-01 00:00:00
abstract::The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957996
更新日期:1995-02-01 00:00:00
abstract::We have previously reported that saiboku-to, an Oriental herbal remedy composed of a mixture of 10 different herbal extracts, possesses anti-histamine release effect on mast cells in rats. This effect may be due mainly to the extract of the bark of Magnolia obovata (M. obovata), a constituent herb of saiboku-to. In th...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2001-18354
更新日期:2001-11-01 00:00:00
abstract::Nano-encapsulation of several natural products has become an important tool in enhancing the bioavailability of some modern drugs against many diseases. Pelargonidin is an anthocyanidin found in many fruits and vegetables. Pelargonidin is loaded with poly-lactide-co-glycolic-acid, a non-toxic biodegradable polymer, to...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-100017
更新日期:2017-03-01 00:00:00
abstract::Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1249861
更新日期:2010-10-01 00:00:00
abstract::Overexpression of the protein transporter P-glycoprotein (Pgp, MDR1) at the cell surface is a major cause of multidrug resistance (MDR) and poor response to treatment in cancer chemotherapy and therapy for leishmaniasis. The present study shows that conferone, a sesquiterpene coumarin ether isolated for the first time...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931574
更新日期:2006-06-01 00:00:00
abstract::Matrine and arsenic trioxide are monomers used in traditional Chinese medicine possessing anti-myeloma activities. In this study, we evaluated the effects and mechanisms of matrine, arsenic trioxide, and their combination therapy on the proliferation and apoptosis of the myeloma cell lines RPMI8226 and U266. The effec...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328554
更新日期:2013-06-01 00:00:00
abstract::Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance for the Pacific Islanders. Kava is also sold as a herbal supplement or recreational beverage consumed for its mild inebriating effect in Europe and North America. With a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0637-2400
更新日期:2018-11-01 00:00:00
abstract::The tertiary and quaternary alkaloids isolated from the stem bark, root bark and seeds of Peschiera fuchsiaefolia are reported. The tertiary alkaloid crude extract from the stem bark was tested in vitro against Plasmodium falciparum on the basis of the antimalarial use of the plant. It showed good activity against bot...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0029-1243122
更新日期:2000-02-01 00:00:00
abstract::Dioscoretine isolated from the aqueous fraction of the methanol extract of Dioscorea dumetorum tubers when administered intra-peritoneally to normal and alloxan diabetic rabbits produces significant hypoglycaemic effects at a dose of 20 mg/kg. The fasting blood sugar in normoglycaemic rabbits was reduced from 112 mg/1...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960952
更新日期:1990-06-01 00:00:00
abstract::The antiinflammatory activity of borjatriol (a diterpenoid isolated from SIDERITIS MUGRONENSIS Borja) was tested using the cotton pellet-granuloma assay. The compound inhibited the granuloma weight and the serum lysozyme activity in a dose-dependently way. The determination of this enzyme has allowed us to distinguish...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969630
更新日期:1984-02-01 00:00:00
abstract::Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative act...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2002-34407
更新日期:2002-09-01 00:00:00
abstract::The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustil...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971448
更新日期:1982-04-01 00:00:00
abstract::Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship w...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2001-16472
更新日期:2001-08-01 00:00:00
abstract::A gas-chromatographical method is described on which seven pyrrolizidine alkaloids (Fuchsisenecionine, Senecionine, Senecivernine, Senkirkine, Retrorsine, O (7)-Angelylheliotridine and Heliotrine) are determinated in a qualitative way and their ratio of concentration in Senecio fuchsii, vernalis, inaequidens and ovire...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971688
更新日期:1981-02-01 00:00:00
abstract::Hepatocellular carcinoma is one of the leading causes of malignancy-related death in China. Its therapy in clinics is a big challenge. Ginsenoside Rh2 is one of the most notable cancer-preventing components from red ginseng and it has been reported that ginsenoside Rh2 exhibited potent cytotoxicity against human hepat...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101764
更新日期:2016-05-01 00:00:00
abstract::A new acylated flavonoid, quercetin 3- O-alpha- L-(5"- O-acetyl)-arabinofuranoside ( 1), along with six known flavonoids ( 2 - 7) were isolated from the aerial parts of Rodgersia podophylla. The new flavonoid 1 exhibited 50.1 % hepatoprotective activity at a concentration of 100 microM, and the three known compounds 3...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827163
更新日期:2004-06-01 00:00:00
abstract::From Polygonum hydropiper L., a C13-norisoprenoid glucoside was isolated and its absolute configuration was established to be (6S,9S)-roseoside (1) by spectroscopic evidence and X-ray crystallographic analysis of its acetate derivative (2). In addition, the stereostructure of roseoside from Canthium subcordatum was re...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2001-15812
更新日期:2001-07-01 00:00:00
abstract::A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum....
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-957701
更新日期:1997-08-01 00:00:00
abstract::DNA barcoding methods originally developed for the identification of plant specimens have been applied to the authentication of herbal drug materials for industrial quality assurance. These methods are intended to be complementary to current morphological and chemical methods of identification. The adoption of these m...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0043-113448
更新日期:2017-10-01 00:00:00