Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

Abstract:

:A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum. Decursinol angelate showed in vitro cytotoxicity and protein kinase C activating activities like decursin.

journal_name

Planta Med

journal_title

Planta medica

authors

Ahn KS,Sim WS,Lee IK,Seu YB,Kim IH

doi

10.1055/s-2006-957701

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

360-1

issue

4

eissn

0032-0943

issn

1439-0221

journal_volume

63

pub_type

信件
  • Five New Triterpenoid Saponins from the Rhizomes of Panacis majoris and Their Antiplatelet Aggregation Activity.

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    journal_title:Planta medica

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    authors: Li M,Liu F,Jin YR,Wang XZ,Wu Q,Liu Y,Li XW

    更新日期:2017-02-01 00:00:00

  • Comparison of the inhibitory effects of monomeric, dimeric, and trimeric procyanidins on the biochemical markers of skin tumor promotion in mouse epidermis in vivo.

    abstract::Several procyanidin dimers and an epicatechin trimer purified from Douglas fir bark tannins were compared with their monomer components (+)-catechin and (-)-epicatechin for their abilities to inhibit the biochemical effects of the potent tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in mouse epidermis in v...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959466

    authors: Gali HU,Perchellet EM,Gao XM,Karchesy JJ,Perchellet JP

    更新日期:1994-06-01 00:00:00

  • Kanerocin: A New Triterpene from the Leaves of Nerium oleander.

    abstract::From the fresh, undried, and uncrushed leaves of NERIUM OLEANDER a new triterpenoid, kanerocin, has been isolated along with known ursolic and oleanolic acids and its structure established through chemical and spectroscopic methods as 3alpha-hydroxy-urs-18,20-dien-28-oic acid. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962009

    authors: Siddiqui S,Siddiqui BS,Begum S,Hafeez F

    更新日期:1989-06-01 00:00:00

  • Prevention of experimentally induced irritant contact dermatitis by extracts of Isatis tinctoria compared to pure tryptanthrin and its impact on UVB-induced erythema.

    abstract::Lipophilic extracts of Isatis tinctoria L. exhibit significant activity against several clinically relevant targets of inflammation. The alkaloid tryptanthrin was identified as one of the active principles in woad and characterised as a potent dual inhibitor of COX-2 and 5-LOX. Here, the anti-inflammatory efficacy of ...

    journal_title:Planta medica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2004-818963

    authors: Heinemann C,Schliemann-Willers S,Oberthür C,Hamburger M,Elsner P

    更新日期:2004-05-01 00:00:00

  • Cytotoxic and antibacterial flavonoids from dragon's blood of Dracaena cambodiana.

    abstract::Chemical studies on the constituents from the dragon's blood of Dracaena cambodiana led to the discovery of three new flavonoid derivatives (1- 3) and six known compounds (4- 9). The structures of the three new compounds were elucidated by NMR and MS spectroscopic analyses. All compounds were evaluated for their growt...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-0031-1280086

    authors: Luo Y,Wang H,Zhao YX,Zeng YB,Shen HY,Dai HF,Mei WL

    更新日期:2011-12-01 00:00:00

  • Two new derivatives of griseofulvin from the mangrove endophytic fungus Nigrospora sp. (strain No. 1403) from Kandelia candel (L.) Druce.

    abstract::Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2 S,5' R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybo...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1271040

    authors: Xia X,Li Q,Li J,Shao C,Zhang J,Zhang Y,Liu X,Lin Y,Liu C,She Z

    更新日期:2011-10-01 00:00:00

  • Prevention of hydrogen peroxide damage by soybean saponins to mouse fibroblasts.

    abstract::Soybean saponin is one of several soybean glycosides. Recently, new soybean saponins which possess the DDMP (2,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one) moiety have been detected. Soyasaponin beta g of these new soybean saponins was shown to inhibit hydrogen peroxide damage to mouse fibroblast cells. Not only t...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957871

    authors: Yoshikoshi M,Yoshiki Y,Okubo K,Seto J,Sasaki Y

    更新日期:1996-06-01 00:00:00

  • Role of thiol agents in protecting against the toxicity of helenalin in tumor-bearing mice.

    abstract::Helanalin, a sesquiterpene lactone antineoplastic agent, is toxic at therapeutic doses in murine tumors. The toxicity has been assumed to be correlated with the binding of the drug to cellular thiol groups. Studies were undertaken to increase the intracellular level of GSH in the liver, kidney and other tissues to eli...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962083

    authors: Hall IH,Grippo AA,Holbrook DJ,Roberts G,Lin HC,Kim HL,Lee KH

    更新日期:1989-12-01 00:00:00

  • [Comparative study of two medicinal Cucurbitaceae].

    abstract::Comparative study of the seeds of two Cucurbitaceae Momordica charantia L. and Herpetospermum caudigerum Wall. shows and important difference for their metabolism concerning particularly aspartic acid. Momordica can produce vicin, while for Herpetospermum, this amino acid would give asparagin. In the other hand, betwe...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971211

    authors: Barron D,Kaouadji M,Mariotte AM

    更新日期:1982-11-01 00:00:00

  • Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.

    abstract::Two new protopine-type alkaloids, argemexicaine A (1) and argemexicaine B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated 1D and 2D NMR, were used to determine the transannul...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-37710

    authors: Chang YC,Hsieh PW,Chang FR,Wu RR,Liaw CC,Lee KH,Wu YC

    更新日期:2003-02-01 00:00:00

  • Antiplatelet aggregation principles from Ephemerantha lonchophylla.

    abstract::Bioactivity-directed separation led to the identification of four compounds, viz. denbinobin (1), 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2), 3-methylgigantol (3), and erianthridin (4) from the ethanolic extract of Ephemerantha lonchophylla. Antiplatelet tests were carried out using 4 different aggregation inducers, ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2000-8553

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    更新日期:2000-05-01 00:00:00

  • Studies on Bignoniaceae: Newbouldiosides D - F, Minor Phenylethanoid Glycosides from Newbouldia laevis, and New Flavonoids from Markhamia zanzibarica and Spathodea campanulata.

    abstract::Continued examination of the stem bark of Newbouldia laevis afforded three minor phenylethanoid glycosides, designated as newbouldiosides D - F. Their structures were elucidated by spectroscopic methods as β-(3,4-dihydroxyphenyl)ethyl 5-O-syringoyl-β-D-apiofuranosyloxy-(1 → 2)-O-[α-L-rhamnopyranosyl-(1 → 3)]-6-O-E-sin...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1270-7761

    authors: Kolodziej H

    更新日期:2020-11-06 00:00:00

  • Detection of some alkaloids on thin layer chromatograms using pi-acceptors.

    abstract::The reactions of chloranil, fluoranil, 2,5 dichlorobenzoquinone and chloranilic acid with some alkaloids on thin layer chromatograms were examined with a view to determine their suitability as visualizing agents. Chloranil and 2,5 dichlorobenzoquinone (each 0.5% w/v in dioxan) were found to be most suitable as they ga...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971381

    authors: Agarwal SP,Elsayed MA

    更新日期:1982-08-01 00:00:00

  • Modified Aloe barbadensis polysaccharide with immunoregulatory activity.

    abstract::Aloe barbadensis polysaccharide was partially digested with cellulase and further purified by dialysis, stepwise ethanol precipitation, and size exclusion chromatography. Crude modified Aloe polysaccharide (MAP) activated macrophage cells and stimulated fibroblast growth. Under the same conditions, native Aloe barbade...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2000-11125

    authors: Qiu Z,Jones K,Wylie M,Jia Q,Orndorff S

    更新日期:2000-03-01 00:00:00

  • Antiamoebic and antigiardial activity of plant flavonoids.

    abstract::The in vitro antiprotozoal activity of 18 natural flavonoids has been determined against Entamoeba histolytica and Giardia lamblia. (-)-Epicatechin, (-)-epigallocatechin and kaempferol were the most active flavonoids against both protozoa. ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960445

    authors: Calzada F,Meckes M,Cedillo-Rivera R

    更新日期:1999-02-01 00:00:00

  • Dermal pharmacokinetics of Terpinen-4-ol following topical administration of Zingiber cassumunar (plai) oil.

    abstract::The purpose of this study was to investigate dermal pharmacokinetics of terpinen-4-ol in rats following topical administration of plai oil derived from the rhizomes of Zingiber cassumunar Roxb. Unbound terpinen-4-ol concentrations in dermal tissue were measured by microdialysis. The dermal pharmacokinetic study of ter...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1315262

    authors: Chooluck K,Singh RP,Sathirakul K,Derendorf H

    更新日期:2012-11-01 00:00:00

  • Multiplication of curcuma species by tissue culture.

    abstract::Callus induction starting from the rhizome tissue of plants of three CURCUMA species: CURCUMA ZEDOARIA Roscoe, C. DOMESTICA Valeton, and C. AROMATICA Salisbury (Zingiberaceae) was performed. Successful callus formation was obtained in all three species using Murashige-Skoog's (MS) medium supplemented with 1-naphthalen...

    journal_title:Planta medica

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    doi:10.1055/s-2006-962344

    authors: Yasuda K,Tsuda T,Shimizu H,Sugaya A

    更新日期:1988-02-01 00:00:00

  • Arbuscular mycorrhizal inoculation enhances survival rates and growth of Micropropagated plantlets of Echinacea pallida.

    abstract::In an attempt to induce positive effects on the acclimatization of in vitro propagated Echinacea pallida, four arbuscular mycorrhizal (AM) fungi, Glomus mosseae, Gigaspora ramisporophora, Scutellospora fulgida and Entrophospora colombiana were selected to aid the soil adaptation process. Fungal inocula affected the su...

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    pub_type: 信件

    doi:10.1055/s-2003-41124

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    更新日期:2003-07-01 00:00:00

  • Detection of Ganoderic Acid A in Ganoderma lingzhi by an Indirect Competitive Enzyme-Linked Immunosorbent Assay.

    abstract::Ganoderma is a genus of medicinal mushroom traditionally used for treating various diseases. Ganoderic acid A is one of the major bioactive Ganoderma triterpenoids isolated from Ganoderma species. Herein, we produced a highly specific monoclonal antibody against ganoderic acid A (MAb 12 A) and developed an indirect co...

    journal_title:Planta medica

    pub_type: 杂志文章

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    更新日期:2016-05-01 00:00:00

  • Effects of genistein, an isoflavone isolated from Genista tridentata, on isolated guinea-pig ileum and guinea-pig ileal myenteric plexus.

    abstract::The inhibitory action of the major constituent of Genista tridentata L. (Papilionaceae), 4',5,7-trihydroxyisoflavone (genistein), on contractions induced by agonists and electrical field stimulation of smooth muscle was analysed. Genistein inhibited twitches evoked by electrical-stimulation of strips of guinea-pig ile...

    journal_title:Planta medica

    pub_type: 杂志文章

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  • Anti-inflammatory Flavanones and Flavanols from the Roots of Pongamia pinnata.

    abstract::A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the...

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  • Composition and antimicrobial activity of the essential oil of Peumus boldus leaves.

    abstract::The composition and the antimicrobial activity of the essential oil from the leaves of Peumus boldus is investigated. Analyses of the oil obtained by hydrodistillation were carried out by GC and GC-MS using columns of two different stationary phases. Fractionation of the essential oil by column chromatography on silic...

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  • Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity.

    abstract::Since the beginning of this century, Goji berries and juice are being sold as health food products in western countries and praised in advertisements and in the media for well-being and as an anti-aging remedy. The popularity of Goji products has rapidly grown over the last years thanks to efficient marketing strategi...

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  • Effect of astilbin on experimental diabetic nephropathy in vivo and in vitro.

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    authors: Barthomeuf C,Demeule M,Grassi J,Saidkhodjaev A,Beliveau R

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  • Diterpenoid Alkaloids from Delphinium caeruleum.

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    pub_type: 杂志文章

    doi:10.1055/s-2006-959611

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  • Modulation of apoptosis by natural products for cancer therapy.

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    doi:10.1055/s-0030-1249961

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    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2000-8533

    authors: Rasmussen HB,Christensen SB,Kvist LP,Karazmi A

    更新日期:2000-05-01 00:00:00

  • Antimalarial compounds containing an alpha,beta-unsaturated carbonyl moiety from Tanzanian medicinal plants.

    abstract::Pure compounds were isolated from plant extracts with antimalarial activity. The extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Zanthoxylum gilletii (De Wild) Waterm. (Rutaceae), and the rootbark of Margaritaria discoidea (Baill.) Webster (Euphorbiaceae). The most active co...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960985

    authors: Weenen H,Nkunya MH,Bray DH,Mwasumbi LB,Kinabo LS,Kilimali VA,Wijnberg JB

    更新日期:1990-08-01 00:00:00