Abstract:
:Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship was established. Subsequently, an antioxidant selectivity index, i. e., the maximal non-toxic dose divided by the IC(50) value for lipid peroxidation, was introduced. Kaempferol showed the highest antioxidant selectivity index of all flavonoids tested.
journal_name
Planta Medjournal_title
Planta medicaauthors
Cos P,Calomme M,Sindambiwe JB,De Bruyne T,Cimanga K,Pieters L,Vlietinck AJ,Vanden Berghe Ddoi
10.1055/s-2001-16472subject
Has Abstractpub_date
2001-08-01 00:00:00pages
515-9issue
6eissn
0032-0943issn
1439-0221journal_volume
67pub_type
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