Abstract:
:Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as well as three acetylated derivatives of 9 were evaluated for their cytotoxicities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) by an MTT assay. Seven limonoids (1, 6, 7, 8, 9, 9b, and 9c) showed significant inhibitory activities against tested cell lines with IC50 values ranging from 0.003 to 0.555 µM, and their preliminary structure-activity relationships are also discussed.
journal_name
Planta Medjournal_title
Planta medicaauthors
Yuan CM,Zhang Y,Tang GH,Li Y,He HP,Li SF,Hou L,Li XY,Di YT,Li SL,Hua HM,Hao XJdoi
10.1055/s-0032-1328069subject
Has Abstractpub_date
2013-01-01 00:00:00pages
163-8issue
2eissn
0032-0943issn
1439-0221journal_volume
79pub_type
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