Bioactive Bafilomycins and a New N-Arylpyrazinone Derivative from Marine-derived Streptomyces sp. HZP-2216E.

abstract：:The inhibitory effect of flavonoids and phenolic acids, which could be transformed from flavonoids by human intestinal microflora, on the growth of Helicobacter pylori (HP) was investigated. Ponciretin, hesperetin, naringenin and diosmetin were active against HP. Among them, ponciretin was the most potent and its MIC ...

journal_title：Planta medica

authors： Bae EA,Han MJ,Kim DH

更新日期：1999-06-01 00:00:00

abstract：:Propolis has been reported to display a broad spectrum of biological activities such as anticancer, antioxidant, anti-inflammatory, antibiotic and antifungal properties, among others. There is great interest not only in the determination of the chemical composition of propolis but also in the understanding of the mech...

journal_title：Planta medica

authors： Tavares DC,Lira WM,Santini CB,Takahashi CS,Bastos JK

更新日期：2007-12-01 00:00:00

abstract：:N-Deacetylcolchiceine (DAC) administered i.p. to rats decreased the level of serum cholesterol and apoB. It was accompanied by the fall of HDL-C due to the decrease of both HDL subfractions HDLa and HDLb, and by a rather weaker decrease of LDL-C. The levels of serum and lipoprotein triacylglycerols were not significan...

journal_title：Planta medica

authors： Skottová N,Vecera R,Walterová D,Simánek V

更新日期：1992-02-01 00:00:00

abstract：:Two new 8-oxotetrahydroprotoberberine alkaloids, gusanlung A(1) and B(2), together with known isoquinoline alkaloids, berberine and jatrorrhizine, were isolated from the Chinese medicinal plant Acangelisia gusanlung H. S. Lo (Menispermaceae). Their structures were elucidated mainly by spectroscopic analysis. ...

journal_title：Planta medica

authors： Zhang JS,Chen ZL

更新日期：1991-10-01 00:00:00

abstract：:Three compounds with anti-inflammatory activity were isolated from Schinus molle fruits. Two of the compounds were identified as 3- epi-isomasticadienolalic acid ( 1), isomasticadienonalic acid ( 2) and chamaejasmin ( 3). Triterpenes 1 and 2, and biflavanone 3 were tested on two models of mice paw inflammation: one of...

journal_title：Planta medica

authors： Yueqin Z,Recio MC,Máñez S,Giner RM,Cerdá-Nicolás M,Ríos JL

更新日期：2003-10-01 00:00:00

abstract：:An Alkanna orientalis leaf and flower extract inhibited the growth of Staphylococcus aureus, a pathogen that causes an estimated 478 000 hospitalizations in the US annually. Bioassay-guided fractionation of A. orientalis resulted in isolation of the flavonoid sarothrin (5,7,4'-trihydroxy-3,6,8-trimethoxyflavone), whic...

journal_title：Planta medica

authors： Bame JR,Graf TN,Junio HA,Bussey RO 3rd,Jarmusch SA,El-Elimat T,Falkinham JO 3rd,Oberlies NH,Cech RA,Cech NB

更新日期：2013-03-01 00:00:00

abstract：:When added to suspension cultures of CATHARANTHUS ROSEUS, abscisic acid (ABA) stimulated intracellular accumulation of the indole alkaloids catharanthine and ajmalicine in both flask and 30 litre fermenter-scale systems. The response varied, and depended upon the cell line, the concentration and source of the ABA, and...

journal_title：Planta medica

authors： Smith JI,Smart NJ,Kurz WG,Misawa M

更新日期：1987-10-01 00:00:00

abstract：:Five new triterpenoid saponins (1-5) and four known triterpenoid saponins, ginsenoside Re5 (6), majonoside R1 (7), 24(R)-majonoside R1 (8), and ginsenoside Rf (9), were isolated from the rhizomes of Panacis majoris. The structures of new compounds were elucidated as (20S,24S,25R*)-6-O-[β-D-glucopyranosyl-(1 → 2)-β-D-g...

journal_title：Planta medica

authors： Li M,Liu F,Jin YR,Wang XZ,Wu Q,Liu Y,Li XW

更新日期：2017-02-01 00:00:00

abstract：:d-Dicentrine was isolated from the root of Lindera megaphylla. It inhibited the aggregation of washed rabbit platelets induced by ADP, collagen, arachidonic acid, and PAF. It also inhibited the high potassium- and norepinephrine-induced contraction of rat thoracic aorta. In rat ventricular cells treated with 3 microM ...

journal_title：Planta medica

authors： Chen CC,Huang YL,Ou JC,Su MJ,Yu SM,Teng CM

更新日期：1991-10-01 00:00:00

abstract：:The new I-3', II-3, 3', II-4', I-5, II-5, I-7, II-7-octahydroxy-I-4'-methoxy-I-3, II-8-biflavanone together with known biflavanones GB-1 and GB-2 were isolated from the bark of GARCINIA KOLA. ...

journal_title：Planta medica

authors： Kabangu K,Galeffi C,Aonzo E,Nicoletti M,Messana I

更新日期：1987-06-01 00:00:00

abstract：:Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...

journal_title：Planta medica

authors： Santhosh RS,Suriyanarayanan B

更新日期：2014-01-01 00:00:00

abstract：:Targeted isolation based on a combination of NMR and HPLC-PDA-MS of a dichloromethane extract of Thymus vulgaris Varico 3 aerial parts afforded one new p-cymene dimer, 6,3',4'-trihydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1: ), together with two known p-cymene derivatives (2: and 3: ), as well as five known compo...

journal_title：Planta medica

authors： Stefanis I,Hadjipavlou-Litina D,Bilia AR,Karioti A

更新日期：2019-08-01 00:00:00

abstract：:Propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing proinflammatory cytokines. In order to demonstrate the anti-inflammatory effects and action mechanisms of magnolol and honokiol, several methods were employed....

journal_title：Planta medica

authors： Lee J,Jung E,Park J,Jung K,Lee S,Hong S,Park J,Park E,Kim J,Park S,Park D

更新日期：2005-04-01 00:00:00

abstract：:Bioassay-directed fractionation of the chloroform-methanol (1:1) extract of Dodonaea viscosa (L.) Jacq. (Sapindaceae) resulted in the isolation of four active spasmolytic principles: sakuranetin (1), 6-hydroxykaempferyl 3,7-dimethyl ether (2) hautrivaic acid (3), and ent-15, 16-epoxy-9 alpha H-labda-13(16)14-diene-3 b...

journal_title：Planta medica

authors： Rojas A,Cruz S,Ponce-Monter H,Mata R

更新日期：1996-04-01 00:00:00

abstract：:Cuttings of a clone of A. annua L. (Asteraceae), grown under 16 h photoperiod for 55 days were transferred to six photoperiod treatments in the greenhouse. Under short photoperiods (8, 10, or 12 h), plants flowered after two weeks; plants under long photoperiods (16, 20, or 24 h) remained vegetative until termination ...

journal_title：Planta medica

authors： Ferreira JF,Simon JE,Janick J

更新日期：1995-04-01 00:00:00

abstract：:The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratin...

journal_title：Planta medica

authors： Kulanthaivel P,Janzen WP,Ballas LM,Jiang JB,Hu CQ,Darges JW,Seldin JC,Cofield DJ,Adams LM

更新日期：1995-02-01 00:00:00

abstract：:Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available tre...

journal_title：Planta medica

authors： Mamede L,Ledoux A,Jansen O,Frédérich M

更新日期：2020-06-01 00:00:00

abstract：:Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedat...

journal_title：Planta medica

authors： Lanhers MC,Fleurentin J,Dorfman P,Mortier F,Pelt JM

更新日期：1991-06-01 00:00:00

abstract：:Plumbagin, an active principle from Plumbaginaceous plants, produced a triphasic inotropic response (first positive, second negative, and third positive phases) in guinea-pig papillary muscle. The inotropic potency of plumbagin at the first positive phase was pD2 6.40, and the methylation of 5-hydroxy group of plumbag...

journal_title：Planta medica

authors： Itoigawa M,Takeya K,Furukawa H

更新日期：1991-08-01 00:00:00

abstract：:Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the meth...

journal_title：Planta medica

authors： Lee HY,Yum JH,Rho YK,Oh SJ,Choi HS,Chang HB,Choi DH,Leem MJ,Choi EJ,Ryu JM,Hwang SB

更新日期：2007-11-01 00:00:00

abstract：:In natural product research, the isolation of biomarkers or bioactive compounds from complex natural extracts represents an essential step for de novo identification and bioactivity assessment. When pure natural products have to be obtained in milligram quantities, the chromatographic steps are generally labourious an...

journal_title：Planta medica

authors： Challal S,Queiroz EF,Debrus B,Kloeti W,Guillarme D,Gupta MP,Wolfender JL

更新日期：2015-11-01 00:00:00

abstract：:At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in...

journal_title：Planta medica

authors： Petit C,Bujard A,Skalicka-Woźniak K,Cretton S,Houriet J,Christen P,Carrupt PA,Wolfender JL

更新日期：2016-03-01 00:00:00

abstract：:The phytochemical investigation of the aerial parts of LACTUCA SALIGNA L. revealed the presence of lactucin, lactucopicrin, and a new guaianolide named 11beta,13-dihydrolactucopicrin. The structural configuration was established through spectral data. ...

journal_title：Planta medica

authors： Khalil AT,El-Fattah HA,Mansour ES

更新日期：1991-04-01 00:00:00

abstract：:Ten clones of dark-leaved willows ( Salix myrsinifolia Salisb.) were grown for two years on two different sites, Luikonlahti and Punkaharju, using various combinations of soil cultivation, fertilization and mulch treatments, with the objective of comparing the effect of different cultivation methods on the growth and ...

journal_title：Planta medica

authors： Heiska S,Rousi M,Turtola S,Meier B,Tirkkonen V,Julkunen-Tiitto R

更新日期：2005-12-01 00:00:00

abstract：:The therapy of type-2 diabetes mellitus is one of the major challenges of our age. A possible strategy to prevent the progression of this disease is the inhibition of protein tyrosine phosphatase 1B (PTP1B), a major negative regulator in the insulin and leptin signalling pathway. Phellodendri amurensis cortex is a wel...

journal_title：Planta medica

authors： Steinmann D,Baumgartner RR,Heiss EH,Bartenstein S,Atanasov AG,Dirsch VM,Ganzera M,Stuppner H

更新日期：2012-02-01 00:00:00

abstract：:Seven new clerodane diterpenoids, dysoxydensins A-G (1-7), together with six known clerodanes, were isolated from Dysoxylum densiflorum. The structures of all the compounds were elucidated by extensive spectroscopic analysis. These compounds were evaluated for their cytotoxic activities against five human cancer cell ...

journal_title：Planta medica

authors： Gu J,Cheng GG,Qian SY,Li Y,Liu YP,Luo XD

更新日期：2014-08-01 00:00:00

abstract：:Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetylshikonin (IC50...

journal_title：Planta medica

authors： Chang YS,Kuo SC,Weng SH,Jan SC,Ko FN,Teng CM

更新日期：1993-10-01 00:00:00

abstract：:The methanol extract of the defatted roots of Asparagus adscendens Roxb. yielded beta-sitosterol beta-D-glucoside, two new spirostanol glycosides (asparanin C and asparanin D) and two new furostanol glycosides (asparoside C and asparoside D). ...

journal_title：Planta medica

authors： Sharma SC,Chand R,Bhatti BS,Sati OP

更新日期：1982-09-01 00:00:00

abstract：:The seed pods of Erythrina latissima yielded erysotrine, erysodine, syringaresinol, vanillic acid, a new erythrina alkaloid, (+)-10,11-dioxoerysotrine, which was lethal to brine shrimp and 2-(5'-hydroxy-3'-methoxy phenyl)-6-hydroxy-5-methoxybenzofuran, which showed strong antimicrobial activity against the yeast spore...

journal_title：Planta medica

authors： Wanjala CC,Juma BF,Bojase G,Gashe BA,Majinda RR

更新日期：2002-07-01 00:00:00

abstract：:Five new dibenzocyclooctane lignans, schisanwilsonins K-O, together with eighteen known lignans were isolated from the stems of Schisandra wilsoniana. The structures of these new compounds were elucidated by spectroscopic methods, including 2D-NMR techniques. Several compounds were found to show anti-HIV and anti-HBV ...

journal_title：Planta medica

authors： Ma WH,Lu Y,Chen DF

更新日期：2013-08-01 00:00:00