Inhibition of platelet aggregation by shikonin derivatives isolated from Arnebia euchroma.

Abstract:

:Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetylshikonin (IC50 = 2.1 microM), teracrylshikonin (2.8 microM), beta, beta-dimethylacrylshikonin (4.2 microM), and shikonin (10.7 microM). In rat aorta, acetylshikonin and shikonin inhibited high potassium and norepinephrine-induced contractions, while beta, beta-dimethylacrylshikonin and teracrylshikonin potentiated the phasic contraction caused by norepinephrine.

journal_name

Planta Med

journal_title

Planta medica

authors

Chang YS,Kuo SC,Weng SH,Jan SC,Ko FN,Teng CM

doi

10.1055/s-2006-959718

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

401-4

issue

5

eissn

0032-0943

issn

1439-0221

journal_volume

59

pub_type

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