Abstract:
:Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetylshikonin (IC50 = 2.1 microM), teracrylshikonin (2.8 microM), beta, beta-dimethylacrylshikonin (4.2 microM), and shikonin (10.7 microM). In rat aorta, acetylshikonin and shikonin inhibited high potassium and norepinephrine-induced contractions, while beta, beta-dimethylacrylshikonin and teracrylshikonin potentiated the phasic contraction caused by norepinephrine.
journal_name
Planta Medjournal_title
Planta medicaauthors
Chang YS,Kuo SC,Weng SH,Jan SC,Ko FN,Teng CMdoi
10.1055/s-2006-959718subject
Has Abstractpub_date
1993-10-01 00:00:00pages
401-4issue
5eissn
0032-0943issn
1439-0221journal_volume
59pub_type
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