Inhibition of HIV-1 reverse transcriptase and HIV-1 replication by Calophyllum coumarins and xanthones.

Abstract:

:As part of our continuing study on the Calophyllum species, a number of coumarins, xanthones and chromene acids from different Calophyllum species of Sri Lanka were tested for inhibitory activity against the HIV-1 and its virally-encoded reverse transcriptase (RT). These compounds were found to be inactive in both the HIV-1 RT and whole virus systems. In contrast, cordatolide A and B demonstrated IC(50) values of 19.3 and 11.7 microM, respectively, against HIV-1 replication in a novel green fluorescent protein (GFP)-based reporter cell assay (HOG.R5).

journal_name

Planta Med

journal_title

Planta medica

authors

Dharmaratne HR,Tan GT,Marasinghe GP,Pezzuto JM

doi

10.1055/s-2002-20058

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

86-7

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

68

pub_type

信件
  • Development of in vitro techniques for the important medicinal plant Veratrum californicum.

    abstract::VERATRUM CALIFORNICUM (Liliaceae) is an important monocotyledonous medicinal plant which is the only source of the anticancer compound cyclopamine. An IN VITRO culture system for somatic embryogenesis and green plant regeneration of VERATRUM CALIFORNICUM was developed. Embryogenic calli were induced from mature embryo...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-946697

    authors: Ma R,Ritala A,Oksman-Caldentey KM,Rischer H

    更新日期:2006-10-01 00:00:00

  • Effects of magnesium lithospermate B and its analogues on Ca(2+) homeostasis in cultured rat thoracic aorta vascular smooth muscle cells.

    abstract::Magnesium lithospermate B (MLB), sodium rosmarinate (SR), and magnesium lithospermate (ML) are biologically active components isolated from aqueous extracts of the Chinese medicine Danshen, the dried root and rhizome of SALVIA MILTIORRHIZA Bunge (Labiatae). These compounds share similar chemical structures of polyphen...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185905

    authors: Chen L,Xuan LJ,Wang YP

    更新日期:2009-12-01 00:00:00

  • A new diterpene from Tanaecium jaroba.

    abstract::One new diterpene, 2 alpha-hydroxy-12beta-hydroxy-isopimara-8(14), 15-diene, and six known compounds as triterpenes, sterols and fatty acid, were isolated from the stem bark of Tanaecium jaroba (Bignoniaceae), a Bolivian plant used in traditional medicine. Their structures were established mainly by 1D and 2D NMR (COS...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-32553

    authors: Mitaine-Offer AC,Sauvain M,Deharo E,Muñoz V,Zèches-Hanrot M

    更新日期:2002-06-01 00:00:00

  • High frequency plant regeneration from leaf derived callus of high Δ9-tetrahydrocannabinol yielding Cannabis sativa L.

    abstract::An efficient in vitro propagation protocol for rapidly producing Cannabis sativa plantlets from young leaf tissue was developed. Using gas chromatography-flame ionization detection (GC-FID), high THC yielding elite female clone of a drug-type CANNABIS variety (MX) was screened and its vegetatively propagated clones we...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1249773

    authors: Lata H,Chandra S,Khan IA,Elsohly MA

    更新日期:2010-10-01 00:00:00

  • Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea.

    abstract::Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines shoul...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1157-1732

    authors: Guzmán-Gutiérrez SL,Silva-Miranda M,Krengel F,Huerta-Salazar E,León-Santiago M,Díaz-Cantón JK,Espitia Pinzón C,Reyes-Chilpa R

    更新日期:2020-05-11 00:00:00

  • Inhibitory activity of the ethyl acetate fraction from Viscum coloratum on bone resorption.

    abstract::The effects of four fractions, a hexane fraction, an ethyl acetate fraction, an N-butanol fraction and a water fraction, from a water extract of Herba Visci were investigated to find the fraction, in IN VITRO experiments, with the greatest ability to inhibit the formation of osteoclast-like multinucleated cells from m...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034283

    authors: Yin J,Han N,Xu X,Liu Z,Zhang B,Kadota S

    更新日期:2008-02-01 00:00:00

  • Antimicrobial hasubanalactam alkaloid from Stephania glabra.

    abstract::A novel hasubanalactam alkaloid, named glabradine, has been isolated from the tubers of Stephania glabra, together with three known quaternary protoberberine alkaloids, palmatine, dehydrocorydalmine and stepharanine. The structure of glabradine was assigned as 7-O-demethyl-N,O-dimethyloxostephinine, by means of rigoro...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0028-1112223

    authors: Semwal DK,Rawat U

    更新日期:2009-03-01 00:00:00

  • Inhibitory activity of chemical constituents from Arenaria serpyllifolia on nitric oxide production.

    abstract::Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-β-D-glucopyranoside (1), one new lignan, 3-(β-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new γ-pyrones, japonicumone A 4'-O-β-D-glucopyranoside (3), japon...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328538

    authors: Zhou GS,Ma XL,Zeng KW,Tu PF,Jiang Y

    更新日期:2013-05-01 00:00:00

  • Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.

    abstract::Valeriana officinalis L. is a popular herbal treatment for mild sleep disorders. Clinical and non-clinical studies found contradictory results for valerian extracts and single constituents regarding the influence on sleep parameters. It was the aim of this study to investigate the sedative effects of a valerian root e...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250589

    authors: Chow NK,Fretz M,Hamburger M,Butterweck V

    更新日期:2011-05-01 00:00:00

  • Diterpenoids from Turraeanthus mannii.

    abstract::Three new compounds, 15-acetoxy-12-hydroxy-16-methyl-labda-8(17),13E-diene (1), ent-labda-8(17),13-dien-15,16-olid-19-oic acid methyl ester (2), and 12-hydroxy-labda-8(17),13-dien-15,16-olide (3), together with two known compounds, 19-acetoxy-ent-labda-8(17),13-dien-15,16-olide (4), and 16-acetoxy-12,15-epoxy-15beta-h...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-967170

    authors: Vardamides JC,Sielinou VT,Ndemangou B,Nkengfack AE,Fomum ZT,Poumale HM,Laatsch H

    更新日期:2007-05-01 00:00:00

  • Stellera chamaejasme and Its Main Compound Luteolin 7-O-Glucoside Alleviates Skin Lesions in Oxazolone- and 2,4-Dinitrochlorobenzene-Stimulated Murine Models of Atopic Dermatitis.

    abstract::Stellera chamaejasme, also known as "Langdu", has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic d...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-0746-8698

    authors: Jo BG,Park NJ,Jegal J,Choi S,Lee SW,Yi LW,Kim SN,Yang MH

    更新日期:2019-05-01 00:00:00

  • New Flavonoids from Boldoa purpurascens Cav.

    abstract::Phytochemical analysis of the leaves of BOLDOA PURPURASCENS Cav. led to isolation of four flavone glycosides, three of which are new compounds. Their structures have been determined by mass spectrometry and by 1 D and 2 D NMR analysis, i. e., 4',5-dihydroxy-6,7-methylenedioxyflavonol 3- O-alpha- L-rhamnopyranosyl-(1--...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1081332

    authors: Mosquera DM,Kilonda A,Toppet S,Compernolle F,Dehaen W,François IE,Cammue BP,Apers S,Pieters L,Cuéllar AC

    更新日期:2008-10-01 00:00:00

  • Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.

    abstract::Two new protopine-type alkaloids, argemexicaine A (1) and argemexicaine B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated 1D and 2D NMR, were used to determine the transannul...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-37710

    authors: Chang YC,Hsieh PW,Chang FR,Wu RR,Liaw CC,Lee KH,Wu YC

    更新日期:2003-02-01 00:00:00

  • [Chemical composition of the essential oil from melissa].

    abstract::Different oil-samples of Melissa officinalis L. were analysed by capillary GC/MS, using fused silica columns and E.I.-Mass-spectrometry. Comparing the observed mass-spectra with those of a spectral collection, 70 compounds of the oil were identified. Geranial, neral, 6-methyl-5-hepten-2-one, citronellal, geranyl-aceta...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-970028

    authors: Tittel G,Wagner H,Bos R

    更新日期:1982-10-01 00:00:00

  • Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages.

    abstract::Isovitexin exhibits potent antioxidant activities. In this study, the activity of nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages after incubation with isovitexin was investigated. Isovitexin was able to reduce the production of hydrogen peroxide induced by LPS in mouse macropha...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-871287

    authors: Lin CM,Huang ST,Liang YC,Lin MS,Shih CM,Chang YC,Chen TY,Chen CT

    更新日期:2005-08-01 00:00:00

  • In vitro effects of Panax ginseng in aristolochic acid-mediated renal tubulotoxicity: apoptosis versus regeneration.

    abstract::This in vitro study aimed to determine the effects of a Panax ginseng extract on aristolochic acid-mediated toxicity in HK-2 cells. A methanolic extract of ginseng (50 µg/mL) was able to reduce cell survival after treatment with 50 µM aristolochic acid for 24, 48, and 72 h, as evidenced by a resazurin reduction assay....

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0035-1545839

    authors: Bunel V,Antoine MH,Nortier J,Duez P,Stévigny C

    更新日期:2015-03-01 00:00:00

  • Network Pharmacology Uncovers Anticancer Activity of Mammea-Type Coumarins from Calophyllum brasiliense.

    abstract::Mammea-type coumarins are a particular type of secondary metabolites biosynthesized by the tropical rainforest tree Calophyllum Brasiliense, which is distributed from South America to Mexico. Particularly, mammea A/BA and A/BB (alone or as a mixture) possess biological properties such as cytotoxic and antitumoral acti...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-0660-0236

    authors: Gómez-Verjan JC,Rivero-Segura NA,Estrella-Parra E,Rincón-Heredia R,Madariaga-Mazón A,Flores-Soto E,González-Meljem M,Cerbón M,Reyes-Chilpa R

    更新日期:2019-01-01 00:00:00

  • Anti HSV-1 flavonoid derivatives tethered with houttuynin from Houttuynia cordata.

    abstract::This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0033-1351051

    authors: Chen SD,Li T,Gao H,Zhu QC,Lu CJ,Wu HL,Peng T,Yao XS

    更新日期:2013-12-01 00:00:00

  • Structure and accumulation of phenolics in elicited Echinacea purpurea cell cultures.

    abstract::Echinacea purpurea cell cultures have been established for the production of secondary and possibly bioactive compounds using elicitation techniques. Different elicitors including yeast elicitor, methyl jasmonate, glutathione, and manganese ions were used and compared for their effects on the formation of phenolics in...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-873201

    authors: Li WW,Barz W

    更新日期:2006-02-01 00:00:00

  • A new cytotoxic trichothecene macrolide from the endophyte Myrothecium roridum.

    abstract::A new cytotoxic roridin-type trichothecene macrolide named roritoxin E(1) was characterized from the solid culture of Myrothecium roridum IFB-E091 (residing originally inside Artemisia annua root), together with the known compounds lumichrome (2), (22 E,24 S)-cerevisterol (3), and (22 E,24 R)-6 beta-methoxy-ergosta-7,...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-0029-1240897

    authors: Shen L,Wang JS,Shen HJ,Song YC,Tan RX

    更新日期:2010-07-01 00:00:00

  • Bioactive polyacetylenes from Bidens pilosa.

    abstract::From the methanolic extract of the whole plants of Bidens pilosa the new beta-D-glucopyranosyloxy-3-hydroxy-6(E)-tetradecen-8, 10,12-triyne besides a known polyine has been isolated and identified mainly by IR and NMR methods. The new compound showed overgrowing action against normal and transformed human cell lines i...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-957902

    authors: Alvarez L,Marquina S,Villarreal ML,Alonso D,Aranda E,Delgado G

    更新日期:1996-08-01 00:00:00

  • In vitro evaluation and pharmacokinetics in dogs of solid dispersion pellets containing Silybum marianum extract prepared by fluid-bed coating.

    abstract::The solid dispersion of a poorly water-soluble Silybum marianum extract (SME) was prepared by a one-step fluid-bed coating technique depositing onto non-pareil pellets. In vitro evaluation indicated that this technique was highly efficient and reproducible producing pellets with acceptable appearance, flowability, fri...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034294

    authors: Sun N,Zhang X,Lu Y,Wu W

    更新日期:2008-02-01 00:00:00

  • Cytotoxic cyclopenta[b]benzofuran derivatives from the stem bark of Aglaia formosana.

    abstract::A new cytotoxic cyclopenta[b]benzofuran derivative, aglaiformosanin (1) and three known cyclopenta[b]benzofuran derivatives (2 - 4) were isolated from the stem bark of Aglaia formosana. Compounds 1 - 4 exhibited potent cytotoxicity against the P-388, KB, HT-29, HL-60, and A549 cell lines. The structure of compound 1 w...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2001-16471

    authors: Wang SK,Duh CY

    更新日期:2001-08-01 00:00:00

  • In vitro formation of crocetin glucosyl esters by Crocus sativus callus extract.

    abstract::Callus extracts of Crocus sativus exhibited the ability to transform all-trans-crocetin into its related glycosides between pH 7.0 and 7.6 in the presence of uridine-diphospho-glucose. The reactions involved the step-wise addition of a glucose moiety to a free carboxyl function and the 1-->6 addition of a glucose moie...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957633

    authors: Dufresne C,Cormier F,Dorion S

    更新日期:1997-04-01 00:00:00

  • The effect of N-deacetylcolchiceine on serum lipoproteins in rats.

    abstract::N-Deacetylcolchiceine (DAC) administered i.p. to rats decreased the level of serum cholesterol and apoB. It was accompanied by the fall of HDL-C due to the decrease of both HDL subfractions HDLa and HDLb, and by a rather weaker decrease of LDL-C. The levels of serum and lipoprotein triacylglycerols were not significan...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:

    authors: Skottová N,Vecera R,Walterová D,Simánek V

    更新日期:1992-02-01 00:00:00

  • Eupatoriopicrin 19-O-Linolenoate and Other Constituents from Eupatorium cannabium.

    abstract::The investigation of the roots and aerial parts of EUPATORIUM CANNABIUM afforded, in addition to the sesquiterpene lactones eupatolide, eupatoriopicrin, and eucannabinolide isolated previously, eight further lactones, three of which are new. Furthermore, in addition to known compounds, a new clerodane derivative and t...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962665

    authors: Zdero C,Bohlmann F

    更新日期:1987-04-01 00:00:00

  • Antiplasmodial activity of the alkaloids of Peschiera fuchsiaefolia.

    abstract::The tertiary and quaternary alkaloids isolated from the stem bark, root bark and seeds of Peschiera fuchsiaefolia are reported. The tertiary alkaloid crude extract from the stem bark was tested in vitro against Plasmodium falciparum on the basis of the antimalarial use of the plant. It showed good activity against bot...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-0029-1243122

    authors: Federici E,Palazzino G,Nicoletti M,Galeffi C

    更新日期:2000-02-01 00:00:00

  • Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism.

    abstract::The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced. The extract of the herb of Ch.majus als...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957924

    authors: Vavrecková C,Gawlik I,Müller K

    更新日期:1996-10-01 00:00:00

  • Guaianolides from Lactuca saligna.

    abstract::The phytochemical investigation of the aerial parts of LACTUCA SALIGNA L. revealed the presence of lactucin, lactucopicrin, and a new guaianolide named 11beta,13-dihydrolactucopicrin. The structural configuration was established through spectral data. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960064

    authors: Khalil AT,El-Fattah HA,Mansour ES

    更新日期:1991-04-01 00:00:00

  • Inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (Curcuma longa).

    abstract::Turmeric has been extensively utilized in Indian and Chinese medicine for its immune-modulatory properties. Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and regulate immunity. The ability of DCs to initiate immunity is linked to their activation status. The effects of turmeric on human DC...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0028-1088367

    authors: Krasovsky J,Chang DH,Deng G,Yeung S,Lee M,Leung PC,Cunningham-Rundles S,Cassileth B,Dhodapkar MV

    更新日期:2009-03-01 00:00:00