Abstract:
:As part of our continuing study on the Calophyllum species, a number of coumarins, xanthones and chromene acids from different Calophyllum species of Sri Lanka were tested for inhibitory activity against the HIV-1 and its virally-encoded reverse transcriptase (RT). These compounds were found to be inactive in both the HIV-1 RT and whole virus systems. In contrast, cordatolide A and B demonstrated IC(50) values of 19.3 and 11.7 microM, respectively, against HIV-1 replication in a novel green fluorescent protein (GFP)-based reporter cell assay (HOG.R5).
journal_name
Planta Medjournal_title
Planta medicaauthors
Dharmaratne HR,Tan GT,Marasinghe GP,Pezzuto JMdoi
10.1055/s-2002-20058subject
Has Abstractpub_date
2002-01-01 00:00:00pages
86-7issue
1eissn
0032-0943issn
1439-0221journal_volume
68pub_type
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