Abstract:
:The absolute stereostructure of a novel skeletal diterpene, standishinal (1), from the bark of Thuja standishii was confirmed by X-ray crystallographic analyses of 1 and its p-bromobenzoate derivative. Aromatase inhibitory activities of standishinal, eight known diterpenes, totarol, 12-methoxyabieta-8,11,13-trien-11-ol, 12-hydroxy-6,7-seco-abieta-8,11,13-triene-6,7-dial, trans-communic acid, labda-8(17),13-dien-12 R,15-olid-19-oic acid, 12 S-hydroxylabda-8(17),13(16),14-trien-19-oic acid, 13-oxo-15,16-dinorlabda-8(17),11 E-dien-19-oic acid and 14-oxo-15-norlabda-8 (17),12 E-dien-19-oic acid from the plant, and four synthetic analogs were evaluated using a recombinant human aromatase. Among them, standishinal and its diacetate derivative had significant inhibitory activities.
journal_name
Planta Medjournal_title
Planta medicaauthors
Minami T,Iwamoto M,Ohtsu H,Ohishi H,Tanaka R,Yoshitake Adoi
10.1055/s-2002-33787subject
Has Abstractpub_date
2002-08-01 00:00:00pages
742-5issue
8eissn
0032-0943issn
1439-0221journal_volume
68pub_type
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