Abstract:
:Activator protein 1 (AP-1) is a transcription factor which plays a critical role in inflammation and carcinogenesis. The present study was conducted to investigate the effect of berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, on the activity of AP-1 using a reporter gene assay in human hepatoma cells. Berberine was shown to inhibit AP-1 activity in a dose- and time-dependent manner at concentrations higher than 0.3 microM. Berberine inhibited AP-1 activity almost completely as low as 10 microM after 48 h treatment. The inhibitory effect on AP-1 activity in cancer cells may further explain the anti-tumor promoting activity of berberine.
journal_name
Planta Medjournal_title
Planta medicaauthors
Fukuda K,Hibiya Y,Mutoh M,Koshiji M,Akao S,Fujiwara Hdoi
10.1055/s-2006-960795subject
Has Abstractpub_date
1999-05-01 00:00:00pages
381-3issue
4eissn
0032-0943issn
1439-0221journal_volume
65pub_type
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