Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase.

Abstract:

:The methanolic extract of the fruits of Torilis japonica showed a potent inhibition against 5 alpha-reductase activity in vitro. Bioassay-guided fractionation of the methanol extract of the fruits followed by repeated silica gel chromatography led to the isolation of an active principle and its structure was identified as torilin on the basis of spectroscopic data. Torilin (IC50 = 31.7 +/- 4.23 microM) showed a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but was weaker than finasteride. (IC50 = 0.38 +/- 0.06 microM). Simple guaiane-type compounds, such as (-)-guaiol and guaiazulene showed weak inhibitory effects on the 5 alpha-reductase activity with IC50 values of f 81.6 microM and 100.8 microM, respectively, while azulene was not active. These results suggest that both degrees of unsaturation and the side-chain in the guaiane skeleton are important for the manifestation of 5 alpha-reductase inhibition.

journal_name

Planta Med

journal_title

Planta medica

authors

Park WS,Son ED,Nam GW,Kim SH,Noh MS,Lee BG,Jang IS,Kim SE,Lee JJ,Lee CH

doi

10.1055/s-2003-39717

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

459-61

issue

5

eissn

0032-0943

issn

1439-0221

journal_volume

69

pub_type

信件
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