Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase.


:The methanolic extract of the fruits of Torilis japonica showed a potent inhibition against 5 alpha-reductase activity in vitro. Bioassay-guided fractionation of the methanol extract of the fruits followed by repeated silica gel chromatography led to the isolation of an active principle and its structure was identified as torilin on the basis of spectroscopic data. Torilin (IC50 = 31.7 +/- 4.23 microM) showed a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but was weaker than finasteride. (IC50 = 0.38 +/- 0.06 microM). Simple guaiane-type compounds, such as (-)-guaiol and guaiazulene showed weak inhibitory effects on the 5 alpha-reductase activity with IC50 values of f 81.6 microM and 100.8 microM, respectively, while azulene was not active. These results suggest that both degrees of unsaturation and the side-chain in the guaiane skeleton are important for the manifestation of 5 alpha-reductase inhibition.


Planta Med


Planta medica


Park WS,Son ED,Nam GW,Kim SH,Noh MS,Lee BG,Jang IS,Kim SE,Lee JJ,Lee CH




Has Abstract


2003-05-01 00:00:00












  • An approach to the antiinflammatory activity of borjatriol.

    abstract::The antiinflammatory activity of borjatriol (a diterpenoid isolated from SIDERITIS MUGRONENSIS Borja) was tested using the cotton pellet-granuloma assay. The compound inhibited the granuloma weight and the serum lysozyme activity in a dose-dependently way. The determination of this enzyme has allowed us to distinguish...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Villar A,Salom R,Alcaraz MJ

    更新日期:1984-02-01 00:00:00

  • New flavonoids from the aerial parts of Aconitum chiisanense.

    abstract::The studies were carried out to evaluate the constituents in the aerial part of Aconitum chiisanense (Ranunculaceae). From the butanol fraction of the methanol extract, kaempferol 3- O-beta-glucopyranoside-7- O-(6-trans-caffeoyl)-beta-glucopyranosyl-(1-->2)-alpha-rhamnopyranoside (I), quercetin 3- O-beta-glucopyranosi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jeong HJ,Whang WK,Kim IH

    更新日期:1997-08-01 00:00:00

  • Structure and accumulation of phenolics in elicited Echinacea purpurea cell cultures.

    abstract::Echinacea purpurea cell cultures have been established for the production of secondary and possibly bioactive compounds using elicitation techniques. Different elicitors including yeast elicitor, methyl jasmonate, glutathione, and manganese ions were used and compared for their effects on the formation of phenolics in...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Li WW,Barz W

    更新日期:2006-02-01 00:00:00

  • New Pseudoguaianolides from Ambrosia maritima.

    abstract::The investigation of the aerial parts of two collections of AMBROSIA MARITIMA afforded in addition to known pseudoguaianolides nine new ones including two nor-sesquiterpene lactones and two dimeric lactones. The structures were elucidated by highfield (1)H-NMR spectroscopy. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jakupovic J,Sun H,Geerts S,Bohlmann F

    更新日期:1987-02-01 00:00:00

  • Galphimine-B modifies electrical activity of ventral tegmental area neurons in rats.

    abstract::Galphimine-B (G-B) is a bioactive compound isolated from the plant Galphimia glauca Cav. (Malpighiaceae) with central nervous system depressant properties previously described. In the present study, extracellular spiking activity records in either somatosensorial cortex or ventral tegmental area (VTA) neurons, were pe...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Tortoriello J,Ortega A,Herrera-Ruíz M,Trujillo J,Reyes-Vázquez C

    更新日期:1998-05-01 00:00:00

  • Barbaloin in aloe species.

    abstract::Barbaloin levels in the exudates from the leaves of 68 species of ALOE in the Kew collection have been determined by light absorption at 375 nm following separation by HPLC. The exudates from most species contained between 10-20% although a few concentrations of around 30% were found. The level in the leaf was usually...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Groom QJ,Reynolds T

    更新日期:1987-08-01 00:00:00

  • Action of 2-hydroxy-4,6-dimethoxyacetophenone isolated from Sebastiania schottiana.

    abstract::The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed. Xanthoxyline (30 to 300 microM) inhibited contractions of t...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Calixto JB,Miguel OG,Yunes RA,Rae GA

    更新日期:1990-02-01 00:00:00

  • Antimalarial compounds containing an alpha,beta-unsaturated carbonyl moiety from Tanzanian medicinal plants.

    abstract::Pure compounds were isolated from plant extracts with antimalarial activity. The extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Zanthoxylum gilletii (De Wild) Waterm. (Rutaceae), and the rootbark of Margaritaria discoidea (Baill.) Webster (Euphorbiaceae). The most active co...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Weenen H,Nkunya MH,Bray DH,Mwasumbi LB,Kinabo LS,Kilimali VA,Wijnberg JB

    更新日期:1990-08-01 00:00:00

  • Dodonic Acid, A New Diterpenoid from Dodonaea viscosa1.

    abstract::The aerial parts of DODONAEA VISCOSA afforded a new diterpenoid, dodonic acid, the structure and stereochemistry of which have been established by chemical and spectroscopic means. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sachdev K,Kulshreshtha DK

    更新日期:1984-10-01 00:00:00

  • In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites.

    abstract::The inhibitory effect of flavonoids and phenolic acids, which could be transformed from flavonoids by human intestinal microflora, on the growth of Helicobacter pylori (HP) was investigated. Ponciretin, hesperetin, naringenin and diosmetin were active against HP. Among them, ponciretin was the most potent and its MIC ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Bae EA,Han MJ,Kim DH

    更新日期:1999-06-01 00:00:00

  • Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells.

    abstract::The involvement of unfolded protein response (UPR) activation in tumor survival and resistance to chemotherapies suggests a new anticancer strategy targeting UPR pathway. Arctigenin, a natural product, has been recently identified for its antitumor activity with selective toxicity against cancer cells under glucose st...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sun S,Wang X,Wang C,Nawaz A,Wei W,Li J,Wang L,Yu DH

    更新日期:2011-01-01 00:00:00

  • Simultaneous determination of lipo-alkaloids extracted from Aconitum carmiechaeli using electrospray ionization mass spectrometry and multiple tandem mass spectrometry.

    abstract::Electrospray ionization mass spectrometry (ESI-MS) combined with multiple tandem mass spectrometry (MS (n)) has been applied for simultaneously determining lipo-alkaloids from the aconite tubers. ESI-MS can give a very good mass separation for lipo-alkaloid mixture and MS (n) can provide structural information. Accord...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sun W,Song F,Cui M,Liu S

    更新日期:1999-06-01 00:00:00

  • Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s.

    abstract::Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. Recently, rutaecarpine has been characterized to have an anti-inflammatory activity through cyclooxygenase-2 inhibition. In the present studies, the effects of rutaecarpine on liver cytochrome P450 s (P450s) and P450 s involved...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee SK,Kim NH,Lee J,Kim DH,Lee ES,Choi HG,Chang HW,Jahng Y,Jeong TC

    更新日期:2004-08-01 00:00:00

  • The Volatile Constituents of Ziziphora taurica subsp. cleonioides.

    abstract::The volatile constituents of ZIZIPHORA TAURICA subsp. CLEONIOIDES (Boiss.) P. H. Davis (Lamiaceae) were studied for the first time by analysis of the essential oil. 33 compounds, from the 44 consisting the total of the fraction, are identified by means of capillary GC and GC-MS. The identified components represent abo...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kokkalou E

    更新日期:1988-04-01 00:00:00

  • Antiplatelet Effects of Flavonoids Mediated by Inhibition of Arachidonic Acid Based Pathway.

    abstract::Flavonoids, important components of human diet, have been claimed to possess a significant antiplatelet potential, in particular due to their effects on the arachidonic acid cascade. Due to variable and incomplete results, this study was aimed at delivering a detailed analysis of the effects of 29 structurally relevan...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Karlíčková J,Říha M,Filipský T,Macáková K,Hrdina R,Mladěnka P

    更新日期:2016-01-01 00:00:00

  • Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis.

    abstract::Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Haraguchi H,Saito T,Okamura N,Yagi A

    更新日期:1995-08-01 00:00:00

  • Hypoglycaemic effect of Coccinia indica: mechanism of action.

    abstract::The hypoglycaemic effect of orally administered extracts of leaves and roots of Coccinia indica has been reported earlier. The oral administration of the pectin isolated from the fruit of the above plant at a dose of 200 mg/100 g BW/day showed a significant hypoglycaemic action in normal rats. Pectins isolated from ma...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kumar GP,Sudheesh S,Vijayalakshmi NR

    更新日期:1993-08-01 00:00:00

  • Accumulation of furanic labdane diterpenes in Marrubium vulgare and Leonurus cardiaca.

    abstract::Accumulation of furanic labdane diterpenes has been investigated in different parts of field-grown plants of MARRUBIUM VULGARE (Lamiaceae) and LEONURUS CARDIACA (Lamiaceae). Furanic labdane diterpenes were produced and accumulated only in the aerial parts. Greatest amounts were measured in leaves and flowers. Up to 4 ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Knöss W,Zapp J

    更新日期:1998-05-01 00:00:00

  • Dietary agonists of TRPV1 inhibit gastric acid secretion in mice.

    abstract::Capsaicin and 6-gingerol, pungent components of chilli pepper and ginger, are known as dietary agonists of transient receptor potential vanilloid-1. Transient receptor potential vanilloid-1 nerve fibers are recognized to play a role in gastric mucosal integrity in rats. In the present studies, we examined the acute ef...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Okumi H,Tashima K,Matsumoto K,Namiki T,Terasawa K,Horie S

    更新日期:2012-11-01 00:00:00

  • A preadipocyte differentiation assay as a method for screening potential anti-type II diabetes drugs from herbal extracts.

    abstract::A cell-based method for screening drug candidates from herbal extracts that have possible anti-type II diabetic effects was established. The differentiation of preadipocytes into adipocytes was used as a sensitive primary indicator of a drug's potential effect on type II diabetes. We established a quantitative method ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xu ME,Xiao SZ,Sun YH,Ou-yang Y,Guan C,Zheng XX

    更新日期:2006-01-01 00:00:00

  • Steroidal saponins from the rhizomes of Dioscorea bulbifera and their cytotoxic activity.

    abstract::Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3- 7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3- O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic acti...

    journal_title:Planta medica

    pub_type: 信件


    authors: Liu H,Chou GX,Wang JM,Ji LL,Wang ZT

    更新日期:2011-05-01 00:00:00

  • Effects of estradiol benzoate, raloxifen and an ethanolic extract of Cimicifuga racemosa in nonclassical estrogen regulated organs of ovariectomized rats.

    abstract::The special extract of Cimicifuga racemosa (CR) BNO 1055 was shown to have bone protective effects without exerting estrogenic effects in the uterus or mammary gland. Whether the effects of CR BNO 1055 would be exerted in other organs that also express estrogen receptors (ERs) but in which the effects of estrogens and...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Seidlova-Wuttke D,Jarry H,Wuttke W

    更新日期:2009-10-01 00:00:00

  • In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates.

    abstract::Six dietary isothiocyanates, allyl-isothiocyanate, benzyl-isothiocyanate, phenylethyl-isothiocyanate, sulforaphane, erucin, and iberin, were tested for their trypanocidal activities in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. All isothiocyanates showed a dose-dependent effect on the growth ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Steverding D,Michaels S,Read KD

    更新日期:2014-02-01 00:00:00

  • Two new C-benzylated dihydrochalcone derivatives from the leaves of Melodorum siamensis.

    abstract::Two new C-benzylated dihydrochalcone derivatives, 4,2',4'-trihydroxy-6'-methoxy-3'(2''-hydroxybenzyl)dihydrochalcone (1) and 2',4'-dihydroxy-4,6'-dimethoxy-3'(2''-hydroxybenzyl)dihydrochalcone (2), along with six known flavonoid derivatives (3-8), a known dihydrochalcone dimer (9), three known aromatic esters (10-12),...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Prawat U,Chairerk O,Phupornprasert U,Salae AW,Tuntiwachwuttikul P

    更新日期:2013-01-01 00:00:00

  • Immobilization of strictosidine synthase from Catharanthus cell cultures and preparative synthesis of strictosidine.

    abstract::Strictosidine synthase was partially purified from Catharanthus roseus cell suspension cultures and immobilized on CNBr-activated Sepharose. The immobilized enzyme exhibits a thermostability increased 300 fold over that of the soluble enzyme and catalyses exclusively the formation of the 3alpha(S)-isomer, strictosidin...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pfitzner U,Zenk MH

    更新日期:1982-09-01 00:00:00

  • Silibinin in vitro protects A549 cells from Staphylococcus aureus-mediated injury and in vivo alleviates the lung injury of staphylococcal pneumonia.

    abstract::In this study, hemolysis, Western blot, and real-time RT-PCR assays were performed to evaluate silibinin's activity against S. aureus α-toxin secretion. In addition, live/dead cell staining and lactate dehydrogenase activity assays were introduced to examine the influence of silibinin on α-toxin-induced cell injury in...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang X,Dong J,Dai X,Zhang Y,Wang J,Li H,Lu C,Tan W,Gao X,Deng X,Bu S,Niu X

    更新日期:2013-01-01 00:00:00

  • Structure-activity relationship of triterpenes and triterpenoid glycosides against tobacco mosaic virus.

    abstract::A new activity of triterpenes and triterpenoid glycosides against phytovirus has been found. Based on the anti-TMV replication activity in vivo, 47 triterpenes and triterpenoid glycosides were screened through the leaf-disk method together with indirect ELISA. Structure-activity relationships were analyzed according t...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang ZK,Ouyang MA,Wu ZJ,Lin QY,Xie LH

    更新日期:2007-11-01 00:00:00

  • Medicinal Plants from Papua New Guinea: Graniline-Esters and Germacranolides from Blumea arfakiana.

    abstract::From the leaves of BLUMEA ARFAKIANA Martelli (Asteraceae), used in traditional medicine in Papua New Guinea, besides stigmasterol and beta-eudesmol, four graniline esters ( 1-4) have been isolated. Furthermore, blumealactone C ( 5), deacetylblumealactone C ( 6), and deoxyblumealactone C ( 7) have been identified. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Rücker G,Paulini G,Sakulas H,Lawong B,Goeltenboth F

    更新日期:1991-06-01 00:00:00

  • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

    abstract::The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavai...

    journal_title:Planta medica

    pub_type: 临床试验,杂志文章


    authors: Shoba G,Joy D,Joseph T,Majeed M,Rajendran R,Srinivas PS

    更新日期:1998-05-01 00:00:00

  • Light-mediated antifungal activity of Echinacea extracts.

    abstract::This study demonstrated that plant extracts containing acetylenic isobutylamides and polyacetylenes, previously reported as occurring in Echinacea, have phototoxic antimicrobial activity against fungi, including clinically relevant pathogenic fungi. Results show that hexane extracts of Echinacea variably inhibit growt...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Binns SE,Purgina B,Bergeron C,Smith ML,Ball L,Baum BR,Arnason JT

    更新日期:2000-04-01 00:00:00