Abstract：
:Kava (Piper methysticum) is an effective anxiolytic that has been withdrawn from various consumer markets in European countries due to concerns over its hepatotoxicity. It is plausible that the reported hepatotoxicity may be due in part to plant substitution, or an incorrect cultivar, or plant parts being used (such as leaves or bark); thus both the plant chemotype and the plant part used may be critical factors. If re-institution of kava in the EU is to occur, more evidence is required to determine its safety and efficacy. Furthermore, according to current evidence, the study of traditional water soluble rhizome extracts using a noble cultivar of kava may be advised. The Kava Anxiety-Lowering Medication (KALM) project is due to start in late 2010 to address these considerations. The KALM project uses an aqueous rhizome extract of a noble cultivar of kava in participants with generalised anxiety and Generalised Anxiety Disorder (GAD). The project comprises of 1) an acute RCT, kava (180 mg of kavalactones) versus oxazepam and placebo in 20 anxious people, testing effects on cognition, mood, anxiety, and driving; 2) an 8-week RCT comparing kava (120 mg kavalactones) versus placebo in 100 patients with GAD. To assess differences between dosages, non-responders at 3 weeks will be titrated to 240 mg of kavalactones. The project will also assess the effects of kava on liver function tests and its side effects profile. A novel component of the project is the pharmacogenomic exploration of phenotypical responses (GABA system and cytochrome P450 markers). The results of the study may be of benefit to sufferers of anxiety and the future economy of the Pacific islands, potentially providing an important step in the way forward with kava.
journal_name
Planta Medjournal_title
Planta medicaauthors
Sarris J,Teschke R,Stough C,Scholey A,Schweitzer Idoi
10.1055/s-0030-1250290subject
Has Abstractpub_date
2011-01-01 00:00:00pages
107-10issue
2eissn
0032-0943issn
1439-0221journal_volume
77pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract：:The endophytic microbiome in medicinal plants is rich and diverse, but few studies have followed the endophytic microbiome of medicinal plants in different tissues with their growth. In this study, we examined the endophytic bacterial and fungal community structures associated with both the stem and root compartments ...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/a-1046-1022
更新日期：2020-09-01 00:00:00
abstract：:Antarctic benthic communities are regulated by abundant interactions of different types among organisms, such as predation, competition, etc. Predators are usually sea stars, with omnivorous habits, as well as other invertebrates. Against this strong predation pressure, many organisms have developed all sorts of defen...
journal_title：Planta medica
pub_type： 杂志文章,评审
doi：10.1055/s-0042-105652
更新日期：2016-06-01 00:00:00
abstract：:An analytical method using HPLC with UV detection was developed to investigate the quassinoid content of Eurycoma longifolia Jack (Simaroubaceae) collected from various sources. Eurycomanone (1), longilactone (2), 14,15beta-dihydroxyklaineanone (3), 15beta-acetyl-14-hydroxyklaineanone (4), 6alpha-hydroxyeurycomalacton...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2006-957570
更新日期：1998-12-01 00:00:00
abstract：:Valepotriates are iridoids found in variable amounts in Valerianaceae and might be among the bioactive compounds which confer anxiolytic properties to the Valeriana species. On the other hand, unspecific cytotoxicity has also been described. Presently, however, no particular molecular target has been defined for these...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-0030-1271084
更新日期：2011-10-01 00:00:00
abstract：:Capsaicin and 6-gingerol, pungent components of chilli pepper and ginger, are known as dietary agonists of transient receptor potential vanilloid-1. Transient receptor potential vanilloid-1 nerve fibers are recognized to play a role in gastric mucosal integrity in rats. In the present studies, we examined the acute ef...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-0032-1315387
更新日期：2012-11-01 00:00:00
abstract：:A lyophilised hydroalcoholic extract of Melissa officinalis L. (Lamiaceae) has been evaluated for behavioral effects in mice. According to the traditional use of M. officinalis, sedative properties have been confirmed for low doses by the decrease of behavioral parameters measured in a non-familiar environment test (s...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2006-960042
更新日期：1991-04-01 00:00:00
abstract：:From the leaves of DIGITALIS LANATA Ehrh. two new Cardenolides have been found and structurally elucidated as Digoxigenin-3-O-beta- D-digitoxosido-beta- D-digitoxosido-beta- D-xyloside bei TLC and spectroscopic methods. ...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2007-969697
更新日期：1984-06-01 00:00:00
abstract：:In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2) and the subsequent...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2007-969527
更新日期：1985-10-01 00:00:00
abstract：:Two indole alkaloids were isolated from the culture of Aspergillus fumigatus (strain No. CY018), an endophytic fungus harboring inside the elder leaf of Cynodon dactylon. These two chemicals were identified as fumigaclavine C and fumitremorgin C. In screening the bioactivity of these two indole alkaloids, their vasore...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2005-916235
更新日期：2006-04-01 00:00:00
abstract：:Isoplexis is a plant genus closely related to Digitalis. Members of this genus contain cardenolides considered more "primitive" than those present in Digitalis. Isoplexis plants, tissue cultures, and isolated cardenolides may thus be used to elucidate the biosynthesis of cardenolides in the Scrophulariaceae. Therefore...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2006-957937
更新日期：1996-10-01 00:00:00
abstract：:The essential oils of Salvia ringens (samples A and B), were analyzed by means of GC and GC/MS. From the seventy-five identified constituents representing 99.82 and 99.86% of the oils, 1,8-cineole and alpha-pinene were the major components. Furthermore, sample B exhibited a very interesting antimicrobial profile after...
journal_title：Planta medica
pub_type： 信件
doi：10.1055/s-2001-10627
更新日期：2001-02-01 00:00:00
abstract：:The therapy of type-2 diabetes mellitus is one of the major challenges of our age. A possible strategy to prevent the progression of this disease is the inhibition of protein tyrosine phosphatase 1B (PTP1B), a major negative regulator in the insulin and leptin signalling pathway. Phellodendri amurensis cortex is a wel...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-0031-1280377
更新日期：2012-02-01 00:00:00
abstract：:Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T-wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bd...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2006-957415
更新日期：1998-04-01 00:00:00
abstract：:Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as uncinatone, cyrtophyllone B, teunvicenone E, sugiol and 12,16-epoxy-11,14-dihydroxy-6-methoxy-17(15 - 16)- abeo-abieta-5,8, 11,13,15-pentaene-3,7-dione. The last compound has only been describ...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2004-815499
更新日期：2004-02-01 00:00:00
abstract：:Three new xanthones, 22,23-dihydroxydihydrogambogenic acid (1), 12-hydroxygambogefic acid A (2), and hanburixanthone (3), along with thirteen known compounds were isolated from the resin of Garcinia hanburyi. The structures of the new compounds were determined by detailed analysis of 1D and 2D NMR spectra and by compa...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-0032-1328537
更新日期：2013-06-01 00:00:00
abstract：:The present study aimed to investigate standardized ethanol extracts of fruit and leaves of Piper sarmentosum for their in vivo antioxidant activity in rats using a CCl (4)-induced oxidative stress model. The standardization was based on the quantification of the markers pellitorine, sarmentine and sarmentosine by hig...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-0029-1186279
更新日期：2010-03-01 00:00:00
abstract：:Bioactivity-guided fractionation of Saururus chinensis (Saururaceae) using a lymphoproliferation assay led us to isolate 5 lignans (compounds 1 - 5). Compounds 1 - 5 were identified as sauchinone, (-)-saucerneol, saucerneol C, manassantin A, and manassantin B, respectively, by spectroscopic analyses. The immunosuppres...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2007-981525
更新日期：2007-06-01 00:00:00
abstract：:Effects of passage of subculture and several culture conditions, nutritional, hormonal and light conditions on 3,4-dihydroxyphenylalanine (DOPA) content were examined in callus of STIZOLOBIUM HASSJOO P IPER and T RACY. The favourable conditions for DOPA accumulation were found to be suboptimal conditions for growth, i...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2007-969828
更新日期：1983-10-01 00:00:00
abstract：:A new steroidal saponin, timosaponin F, along with six known compounds was isolated from the rhizomes of Anemarrhena asphodeloides Bge. On the basis of chemical and spectroscopic evidence, the structure of timosaponin F was elucidated as (5beta, 25 S):-spirostan-3beta,15alpha,23alpha-triol-3-O-beta- glucopyranosyl-(1-...
journal_title：Planta medica
pub_type： 信件
doi：10.1055/s-2006-960842
更新日期：1999-10-01 00:00:00
abstract：:The quantification of free and total alkannins in 13 endemic Anatolian Alkanna species is described for the first time. Extraction of the samples was performed by sonication with hexane, followed by hydrolysis in 1 N NaOH. For analysis, a new HPLC method, utilizing reversed phase material (Synergi Max RP), was develop...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2007-967110
更新日期：2007-03-01 00:00:00
abstract：:From the defatted seeds of Cassia marginata fam (Caesalpinaceae) two new anthraquinone glycosides have been isolated and characterised as physcion-8-O-alpha-L-xylopyranoside and emodin-8-O-alpha-L-arabinopyranoside. ...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2007-971241
更新日期：1982-05-01 00:00:00
abstract：:A museum collection of Cinchonae cortex samples (n = 117), from the period 1850-1950, was extracted with a mixture of chloroform-d1, methanol-d4, water-d2, and perchloric acid in the ratios 5 : 5 : 1 : 1. The extracts were directly analyzed using 1H NMR spectroscopy (600 MHz) and the spectra evaluated using principal ...
journal_title：Planta medica
pub_type： 历史文章,杂志文章
doi：10.1055/s-0032-1315396
更新日期：2012-11-01 00:00:00
abstract：:(1)H- and (13)C-NMR spectral data are presented for six p-terphenylquinone derivatives (and for two monosubstituted quinones 1 and 2, used as model compounds) and for 9,10-phenanthraquinone and retenequinone. The chemical shifts were confirmed through correlation spectroscopy and NOE measurements. ...
journal_title：Planta medica
pub_type： 信件
doi：10.1055/s-2006-957712
更新日期：1997-08-01 00:00:00
abstract：:Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with t...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2002-34930
更新日期：2002-10-01 00:00:00
abstract：:Based on rDNA ITS sequences of D. officinale and the other 37 species of Dendrobium, a pair of allele-specific diagnostic primers, TP-JB01S and TP-JB01X, were designed to authenticate D. officinale from the other species. Before the diagnostic PCR, the primer pair, P1 and P2, for amplifying the whole ITS region was us...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2003-40651
更新日期：2003-06-01 00:00:00
abstract：:Mulberroside A, a major stilbene constituent of MORUS ALBA L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and fec...
journal_title：Planta medica
pub_type： 信件
doi：10.1055/s-0029-1186160
更新日期：2010-03-01 00:00:00
abstract：:Three pyrrolizidine alkaloids were isolated from Eupatorium portoricense and their structures elucidated by spectroscopic methods as (-)-viridifloryl-supinidine (amabiline), (-)-viridifloryl-heliotridine (echinatine), and C12- O-acetyl-(-)-viridifloryl-heliotridine (O(12)-acetylechinatine). ...
journal_title：Planta medica
pub_type： 信件
doi：10.1055/s-2006-958112
更新日期：1995-08-01 00:00:00
abstract：:Praziquantel is the drug of choice for the treatment of schistosomiasis. However, several strains of Schistosoma mansoni are resistant to praziquantel, making it necessary to discover new drugs that might be used for its treatment. With this in mind, the properties of a schistosomicidal ethanolic extract of Garcinia b...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-0035-1545927
更新日期：2015-06-01 00:00:00
abstract：:The aim of this study was to investigate the protective effect of (S)-bakuchiol isolated from the seed of Psoralea corylifolia, on liver injury. Primary rat hepatocyte intoxication was induced by tert-butyl hydroperoxide (tBH), carbon tetrachloride (CCl4) or D-galactosamine (D-GalN). Liver injury was induced by either...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2005-864150
更新日期：2005-06-01 00:00:00
abstract：:The crude methanol extract of the Kenyan shrub Leucas volkensii Gürke (Labiatae) displayed in a radiorespirometric bioassay antimycobacterial activity against Mycobacterium tuberculosis. Bioassay-guided fractionation of the crude extract led to the identification of (E)-phytol as the principal active component with a ...
journal_title：Planta medica
pub_type： 杂志文章
doi：10.1055/s-2006-957354
更新日期：1998-02-01 00:00:00
