Antibacterial properties of phenolic triterpenoids against Staphylococcus epidermidis.

Abstract:

:Two phenolic triterpenoids, pristimerol (30 µg/mL) and 8- EPI-6-deoxoblepharodol (20 µg/mL), obtained by catalytic reduction of pristimerin, exhibited bacteriostatic action against Staphylococcus epidermidis. This activity was not dependent on the inoculum size and the growth phase although it showed a stronger effect when cells were growing actively. Addition of phenolic triterpenoids to S. epidermidis cultures in the log-phase of growth led to an inhibitory effect on incorporation and uptake of radiolabeled precursors thymidine, uridine, leucine, and N-acetyl-glucosamine after 30 min of treatment. Furthermore, a clear release of UV-absorbing material and leakage of intracellular potassium were also detected. These findings, coupled with the high lipophilicity of these molecules, shown by high ClogP values, suggest that 8-EPI and pristimerol are able to interact within the lipid bilayer and as a consequence cause functional alterations on the cytoplasmic membrane of S. epidermidis cells.

journal_name

Planta Med

journal_title

Planta medica

authors

López MR,de León L,Moujir L

doi

10.1055/s-0030-1250500

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

726-9

issue

7

eissn

0032-0943

issn

1439-0221

journal_volume

77

pub_type

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