Abstract:
:The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.
journal_name
Planta Medjournal_title
Planta medicaauthors
Yamaji K,Sarker KP,Maruyama I,Hizukuri Sdoi
10.1055/s-2002-20050subject
Has Abstractpub_date
2002-01-01 00:00:00pages
16-9issue
1eissn
0032-0943issn
1439-0221journal_volume
68pub_type
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