Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro.

Abstract:

:The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.

journal_name

Planta Med

journal_title

Planta medica

authors

Yamaji K,Sarker KP,Maruyama I,Hizukuri S

doi

10.1055/s-2002-20050

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

16-9

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

68

pub_type

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