Abstract:
:Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC(50) values of 19.1 +/- 3.6 and 3.81 +/- 0.5 microM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC(50) = 23.4 +/- 1.5 microM). Compounds 2 and 4 showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.42 and 32.3 +/- 2.62 micro, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
journal_name
Planta Medjournal_title
Planta medicaauthors
Oh H,Ko EK,Jun JY,Oh MH,Park SU,Kang KH,Lee HS,Kim YCdoi
10.1055/s-2002-34930subject
Has Abstractpub_date
2002-10-01 00:00:00pages
932-4issue
10eissn
0032-0943issn
1439-0221journal_volume
68pub_type
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